IFOM

Publications Giorgio Scita

Publication record

Scita-pubblicazioni

In the last ten years (2005-2015) he published, as corresponding author, 15 original publications, including 1 paper in Cell, 1 in Immunity, 2 in NCB, 1 in Developmental Cell, 2 in Plos Biology, 3 in Current Biology, 1 EMBO, 1 in J. of Cell Biology, 1 in Plos Genetics and 1 in MBoC, 1 in Plos Comp Biology; plus reviews and commentaries in Nature, Physiol. Rev., Current Opinion of Cell biology, Trends in Cell Biology, Dev Cells and other peer reviewed journals and a variety of collaborative work in Cell, Nature Cell Biology, Nature structural Cell Biology, Cell Stem Cell, EMBO J., The journal of Cell Biology etc. He has also published 3 book chapters and 3 meeting proceedings.

 

TOP PAPERS AS SENIOR AUTHOR (last 10 years)
H index+ 50 Total Pub=114
(IF according to Journal of Citation Report released in June 2016)

  1. Gerboth, S., Frittoli, E., Palamidessi, A., Baltanas, FC., Mogjiborahman, S., Rappsilber, J., Giuliani, C., Troglio, F., Rolland, Y., Pruneri, G., Kreutmair, S., Pallavicini, I., Zobel, M., Cinquanta, M., Minucci, S., Gomez, C., Santos, E., Illert, AI., Scita, G. 2017.
    Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.
    Leukemia. Aug 18. [Epub ahead of print] IF= 11.702

  2. Malinverno, C., S. Corallino, F. Giavazzi, M. Bergert, Q. Li, M. Leoni, A. Disanza, E. Frittoli, A. Oldani, E. Martini, T. Lendenmann, G. Deflorian, G.V. Beznoussenko, D. Poulikakos, K.H. Ong, M. Uroz, X. Trepat, D. Parazzoli, P. Maiuri, W. Yu, A. Ferrari, R. Cerbino, and G. Scita. 2017.
    Endocytic reawakening of motility in jammed epithelia.
    Nature Materials. 16:587-596. IF = 39.74

  3. Malet-Engra, G., W. Yu, A. Oldani, J. Rey-Barroso, N.S. Gov, G. Scita, and L. Dupre. 2015.
    Collective cell motility promotes chemotactic prowess and resistance to chemorepulsion.
    Current Biology. 25:242-250. IF= 8.85
    * Corresponding author (the first author of the manuscript is a Post doctoral fellow in my group).

  4. Rolland, Y., P. Marighetti, C. Malinverno, S. Confalonieri, C. Luise, N. Ducano, A. Palamidessi, S. Bisi, H. Kajiho, F. Troglio, O.G. Shcherbakova, A.R. Dunn, A. Oldani, L. Lanzetti, P.P. Di Fiore, A. Disanza, and G. Scita. 2014.
    The CDC42-Interacting Protein 4 Controls Epithelial Cell Cohesion and Tumor Dissemination.
    Developmental Cell. 30:553-568. IF= 9.174

  5. Frittoli, E., A. Palamidessi, P. Marighetti, S. Confalonieri, F. Bianchi, C. Malinverno, G. Mazzarol, G. Viale, I. Martin-Padura, M. Garre, D. Parazzoli, V. Mattei, S. Cortellino, G. Bertalot, P.P. Di Fiore, and G. Scita. 2014.
    A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination.
    J Cell Biol. 206:307-328 IF= 7.96

  6. Disanza A., Bisi S, Winterhoff, M. Milanesi, F., Ushakov, D.S., Kast, D., Marighetti, P., Romet-Lemonne, G., Müller, H_M., Nickel, W., Linkner, J., Waterschoot, D., Ampè, C., Cortellino, S., Palamidessi, A., Dominguez, R., Carlier, M-F., Faix, J., and Scita, G..
    CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP.
    EMBO J. Oct 16;32(20):2735-50. IF= 9.792

  7. Palamidessi, A., E. Frittoli, N. Ducano, N. Offenhauser, S. Sigismund, H. Kajiho, D. Parazzoli, A. Oldani, M. Gobbi, G. Serini, P.P. Di Fiore, G. Scita*, and L. Lanzetti. 2013.
    The GTPase-activating protein RN-tre controls focal adhesion turnover and cell migration.
    Current Biology. 23:2355-2364 IF= 8.85
    * Corresponding author (the first author of the manuscript is a Post doctoral fellow in my group).

  8. Frittoli, E., Matteoli, G., Palamidessi, A., Mazzini, E., Maddaluno, L., Disanza, A., Yang, C., Svitkina, T., Rescigno, M., and Scita, G. (2011).
    The signaling adaptor eps8 is an essential actin capping protein for dendritic cell migration.
    Immunity 35, 388-399 IF= 19.748 Citation=22.85

  9. M. Hertzog, F. Milanesi, L. Hazelwood, A. Disanza, H. Liu, E. Perlade, M. Malabarba, S. Pasqualato, A. Maiolica, S. Confalonieri, C. Le Clainche, N. Offenhauser, J. Block, K. Rottner, P. P. Di Fiore, M.-F. Carlier, N. Wolkmann, D. Hanein, G. Scita, 2010.
    Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping.
    PLoS Biology. June 8, e1000387. IF= 9.80

  10. Palamidessi, A, Frittoli, E. Faretta, M. Diaspro , A, Letizia Lanzetti, Scita, G.* and Di Fiore, P.P.
    Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration.
    Cell (2008). Jul 11;134(1):18-20. IF= 30.41
    * Corresponding author (the first author of the manuscript is a Post doctoral fellow in my group)

TOP RESEARCH REVIEWS

  1. Bisi, S., Disanza, A., Malinverno, C., Frittoli, E., Palamidessi, A., Scita, G., 2013.
    Membrane and actin dynamics interplay at lamellipodia leading edge.
    Current opinion in cell biology. 2013 Oct;25(5):565-73
    IF= 9.94

  2. Sigismund, S., S. Confalonieri, A. Ciliberto, S. Polo, G. Scita, and P.P. Di Fiore. 2012.
    Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.
    Physiol Rev. 92:273-366
    IF= 27.31

  3. G. Scita and PP Di Fiore.
    The Endocytic Matrix.
    Nature. Jan 28, 2010.
    IF= 40.137

  4. Scita, G., Confalonieri, S., Lappalainen, P. & Suetsugu, S.
    IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions.
    Trends Cell Biol 18, 52-60 (2008).
    IF= 15.333

All Publications by Year (2011-2017)

2017

  1. Gerboth, S., E. Frittoli, A. Palamidessi, F. C. Baltanas, M. Salek, J. Rappsilber, C. Giuliani, F. Troglio, Y. Rolland, G. Pruneri, S. Kreutmair, I. Pallavicini, M. Zobel, M. Cinquanta, S. Minucci, C. Gomez, E. Santos, A. L. Illert and G. Scita (2017).
    Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.
    Leukemia

  2. Teske, C., C. Schweitzer, A. Palamidessi, D. E. Aust, G. Scita, J. Weitz and T. Welsch (2017).
    Modulation of RAB5A early endosome trafficking in response to KRas mediated macropinocytic fluxes in pancreatic cancer cells.
    Biochem Biophys Res Commun.

  3. Tod, J., C. J. Hanley, M. R. Morgan, M. Rucka, T. Mellows, M. A. Lopez, P. Kiely, K. A. Moutasim, S. J. Frampton, D. Sabnis, D. R. Fine, C. Johnson, J. F. Marshall, G. Scita, V. Jenei and G. J. Thomas (2017).
    Pro-migratory and TGF-beta-activating functions of alphavbeta6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch.
    J Pathol 243(1): 37-50

  4. Lorincz, P., S. Toth, P. Benko, Z. Lakatos, A. Boda, G. Glatz, M. Zobel, S. Bisi, K. Hegedus, S. Takats, G. Scita, and G. Juhasz. 2017.
    Rab2 promotes autophagic and endocytic lysosomal degradation.
    J Cell Biol. May 8th electronic.

  5. Kajiho, H., Y. Kajiho, and G. Scita. 2017.
    Harnessing membrane trafficking to promote cancer spreading and invasion: The case of RAB2A.
    Small GTPases:1-6

  6. Malinverno, C., S. Corallino, F. Giavazzi, M. Bergert, Q. Li, M. Leoni, A. Disanza, E. Frittoli, A. Oldani, E. Martini, T. Lendenmann, G. Deflorian, G.V. Beznoussenko, D. Poulikakos, K.H. Ong, M. Uroz, X. Trepat, D. Parazzoli, P. Maiuri, W. Yu, A. Ferrari, R. Cerbino, and G. Scita. 2017.
    Endocytic reawakening of motility in jammed epithelia.
    Nature materials. 16:587-596.

  7. Toffali, L., A. Montresor, M. Mirenda, G. Scita, and C. Laudanna. 2017.
    SOS1, ARHGEF1, and DOCK2 rho-GEFs Mediate JAK-Dependent LFA-1 Activation by Chemokines.
    J Immunol. 198:708-717.

2016

  1. Delage, E., D.C. Cervantes, E. Penard, C. Schmitt, S. Syan, A. Disanza, G. Scita, and C. Zurzolo. 2016.
    Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes.
    Scientific reports. 6:39632

  2. Chepizhko, O., C. Giampietro, E. Mastrapasqua, M. Nourazar, M. Ascagni, M. Sugni, U. Fascio, L. Leggio, C. Malinverno, G. Scita, S. Santucci, M.J. Alava, S. Zapperi, and C.A. La Porta. 2016.
    Bursts of activity in collective cell migration.
    Proc Natl Acad Sci U S A. 113:11408-11413

  3. Ballabeni, A., D. Hemenway, and G. Scita. 2016.
    Time to tackle the incumbency advantage in science: A survey of scientists shows strong support for funding policies that would distribute funds more evenly among laboratories and thereby benefit new and smaller research groups.
    EMBO Rep. 17, 1254-1256

  4. Biondini, M., A. Sadou-Dubourgnoux, P. Paul-Gilloteaux, G. Zago, M.D. Arslanhan, F. Waharte, E. Formstecher, M. Hertzog, J. Yu, R. Guerois, A. Gautreau, G. Scita, J. Camonis, and M.C. Parrini. 2016.
    Direct interaction between Exocyst and Wave complexes promotes cell protrusions and motility.
    J Cell Sci, 129, 3756-3769.

  5. Scita, G., C. Sorrentino, A. Boggio, D. Hemenway, and A. Ballabeni. 2016.
    Increasing the public health potential of basic research and the scientist satisfaction. An international survey of bioscientists.
    F1000Res. 5:56.

  6. Kajiho H, Kajiho Y, Frittoli E, Confalonieri S, Bertalot G, Viale G, Di Fiore PP, Oldani A, Garre M, Beznoussenko GV, Palamidessi A, Vecchi M, Chavrier P, Perez F, Scita G.
    RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs.
    EMBO Rep. 2016 Jun 2. pii: e201642032. [Epub ahead of print]

2015

  1. Giampietro, C., Disanza, A., Bravi, L., Barrios-Rodiles, M., Corada, M., Frittoli, E., Savorani, C., Lampugnani, M. G., Boggetti, B., Niessen, C., Wrana, J. L., Scita, G., and Dejana, E. (2015)
    The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling.
    J Cell Biol pii: jcb.201501089. [Epub ahead of print]
    G.S. and E.D. Co-corresponding authors

  2. Cremaschi P, Oliverio M, Leva V, Bione S, Carriero R, Mazzucco G, Palamidessi A, Scita G, Biamonti G, Montecucco A (2015)
    Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells.
    PLoS One 10: e0130561

  3. Linder S, Scita G (2015)
    RABGTPases in MT1-MMP trafficking and cell invasion: Physiology versus pathology.
    Small GTPases 6: 145-52

  4. Corallino S, Malabarba MG, Zobel M, Di Fiore PP, Scita G.
    Epithelial-to-Mesenchymal Plasticity Harnesses Endocytic Circuitries.
    Front Oncol. 2015 Feb 26;5:45. doi: 10.3389/fonc.2015.00045. eCollection 2015. Review.

  5. Disanza, A., and Scita, G. (2015).
    Nuclear and Cellular Plasticity: Nuclear RAC1 Takes Center Stage.
    Dev Cell 32, 261-263

  6. Malet-Engra, G., Yu, W., Oldani, A., Rey-Barroso, J., Gov, N.S., Scita, G., and Dupre, L. (2015).
    Collective cell motility promotes chemotactic prowess and resistance to chemorepulsion.
    Curr Biol 25, 242-250.
    G.S. and L.D Co-corresponding authors

2014

  1. Rolland, Y., Marighetti, P., Malinverno, C., Confalonieri, S., Luise, C., Ducano, N., Palamidessi, A., Bisi, S., Kajiho, H., Troglio, F., et al. (2014).
    The CDC42-Interacting Protein 4 Controls Epithelial Cell Cohesion and Tumor Dissemination.
    Dev Cell 30, 553-568

  2. Kumar, A., Mazzanti, M., Mistrik, M., Kosar, M., Beznoussenko, G.V., Mironov, A.A., Garre, M., Parazzoli, D., Shivashankar, G.V., Scita, G., et al. (2014).
    ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress.
    Cell 158, 633-646.

  3. Frittoli, E., Palamidessi, A., Marighetti, P., Confalonieri, S., Bianchi, F., Malinverno, C., Mazzarol, G., Viale, G., Martin-Padura, I., Garre, M., et al. (2014).
    A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination.
    J Cell Biol. 2014 Jul 21;206(2):307-28. doi: 10.1083/jcb.201403127.

  4. Kast, D.J., Yang, C., Disanza, A., Boczkowska, M., Madasu, Y., Scita, G., Svitkina, T., and Dominguez, R. (2014b).
    Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors.
    Nat Struct Mol Biol 21, 413-422

  5. Maroni, P., P. Bendinelli, E. Matteucci, A. Locatelli, T. Nakamura, G. Scita, and M.A. Desiderio. 2014.
    Osteolytic bone metastasis is hampered by impinging on the interplay among autophagy, anoikis and ossification.
    Cell death & disease. 5:e1005.

2013

  1. A. Palamidessi, E. Frittoli, N. Ducano, N. Offenhauser, S. Sigismund, H. Kajiho, D. Parazzoli, A. Oldani, M Gobbi, G. Serini, P. P.Di Fiore, Giorgio Scita. and L. Lanzetti. 2013
    RN-tre controls focal adhesion turnover and cell migration.
    Curr Bio. 2013. Dec 2;23(23):2355-64.
    G.S. and L.L. Co-corresponding author

  2. Ferrari I, Crespi A, Scita G, Pietrini G.
    LIN7-IRSp53: A novel pathway for filopodia and neurite formation.
    Commun Integr Biol. 2012 Nov 1;5(6):631-3. doi: 10.4161/cib.21686.

  3. S. Comes, M. Gagliardi, N. Laprano, A. Cimmino, A. Palamidessi, A. Fico, D. De Cesare, S. De Falco, C. Angelini, G. Scita, E. J. Patriarca, M.R. Matarazzo and G. Minchiotti.
    L-Proline induces a mesenchymal-like invasive program in embryonic stem cells by remodeling H3K9 and H3K36 methylation.
    Stem Cell Reports. 2013 Oct 10;1(4):307-21.

  4. Disanza A., Bisi S, Winterhoff, M. Milanesi, F., Ushakov, D.S., Kast, D., Marighetti, P., Romet-Lemonne, G., Müller, H_M., Nickel, W., Linkner, J., Waterschoot, D., Ampè, C., Cortellino, S., Palamidessi, A., Dominguez, R., Carlier, M-F., Faix, J., and Scita, G..
    CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP.
    EMBO J. Oct 16;32(20):2735-50.

  5. Bisi, S., Disanza, A., Malinverno, C., Frittoli, E., Palamidessi, A., Scita, G., 2013.
    Bisi, S., Disanza, A., Malinverno, C., Frittoli, E., Palamidessi, A., Scita, G., 2013.
    Current opinion in cell biology. 2013 Oct;25(5):565-73

  6. Malet-Engra, G., Viaud, J., Ysebaert, L., Farce, M., Lafouresse, F., Laurent, G., Gaits-Iacovoni, F., Scita, G., Dupre, L., 2013.
    CIP4 controls CCL19-driven cell steering and chemotaxis in chronic lymphocytic leukemia.
    Cancer research 73:3412-3424

  7. Menna, E., Zambetti, S., Morini, R., Donzelli, A., Disanza, A., Calvigioni, D., Braida, D., Nicolini, C., Orlando, M., Fossati, G., Cristina Regondi, M., Pattini, L., Frassoni, C., Francolini, M., Scita, G., Sala, M., Fahnestock, M., Matteoli, M., 2013.
    Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity.
    EMBO J. 32:1730-1744.

  8. Achim Werner, Andrea Disanza, Nina Reifenberger, Gregor Habeck, Janina Becker, Matthew Calabrese, Henning Urlaub, Holger Lorenz, Brenda Schulman, Giorgio Scita, Frauke Melchior.
    SCFFbxw5 mediates transient degradation of actin remodeler Eps8 to allow proper mitotic progression.
    Nature cell biology. 15:179-188. 2013.

2012

  1. Wiedmann, R. M., von Schwarzenberg, K., Palamidessi, A., Schreiner, L., Kubisch, R., Liebl, J., Schempp, C., Trauner, D., Vereb, G., Zahler, S., Wagner, E., Muller, R., Scita, G M. et al.
    The V-ATPase-Inhibitor Archazolid Abrogates Tumor Metastasis via Inhibition of Endocytic Activation of the Rho-GTPase Rac1.
    Cancer research, doi:10.1158/0008-5472.CAN-12-1772 (2012)

  2. Crespi, A., Ferrari, I., Lonati, P., Disanza, A., Fornasari, D., Scita, G., Padovano, V., Pietrini, G., 2012.
    LIN7 regulates the filopodia and neurite promoting activity of IRSp53.
    J Cell Sci. 2012 Oct 1;125(Pt 19):4543-54

  3. Sigismund, S. et al.
    Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.
    Physiol Rev 92, 273 -366, doi:92/1/273 [pii]10.1152/physrev.00005.2011 (2012).

2011

  1. Frittoli, E., Matteoli, G., Palamidessi, A., Mazzini, E., Maddaluno, L., Disanza, A., Yang, C., Svitkina, T., Rescigno, M., and Scita, G. (2011).
    The signaling adaptor eps8 is an essential actin capping protein for dendritic cell migration.
    Immunity 35, 388-399

  2. Vaggi, F., Disanza, A., Milanesi, F., Di Fiore P.P., Menna, E., Matteoli, M., Gov, N., Scita, G.*, and Ciliberto, A*. 2011.
    The Eps8/IRSp53/VASP network differentially controls actin capping and bundling in filopodia formation.
    PLoS Comput Biol. 2011 Jul;7(7):e1002088

  3. Peleg B, Disanza A, Scita G, Gov N.
    Propagating cell-membrane waves driven by curved activators of actin polymerization
    PLoS One. 2011 Apr 21;6(4):e18635.

  4. De Laurentiis, A., Pardo, O. E., Palamidessi, A., Jackson, S. P., Schoenwaelder, S. M., Reichmann, E., Scita, G., Arcaro, A., 2011.
    The catalytic class I(A) PI3K isoforms play divergent roles in breast cancer cell migration.
    Cell Signal. 23, 529-41.

  5. Manor, U., Disanza, A., Grati, M., Andrade, L., Lin, H., Di Fiore, P. P., Scita, G., Kachar, B., 2011.
    Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8.
    Curr Biol. 21, 167-72.