IFOM Simona Polo Lab

Simona Polo Lab

Simona Polo

Simona Polo

Dr. Simona Polo, an expert in molecular and cell biology, is the director of the Molecular Machines in Signaling Pathways research program at IFOM since 2005.

Dr. Polo was born in Milan in 1968 and studied biological sciences at the University of Milan under the supervision of Prof. Daniela Ghisotti, graduating cum laude in 1991 and honorable mention. Her thesis on bacteriophage P4 received the price for the best thesis in genetics in 1991 from the AGI association.

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Molecular Machines in Signalling Pathways

Signaling networks are complex and robust, and they are based on macromolecular complexes with fine-grained structure-function modularity. At the cellular level, signaling networks are spatiotemporally regulated by post-translational modifications that render the systems highly dynamic. Our main research interest is focus on the characterization of protein complexes that are modulated by ubiquitination at the physiological and pathological levels.

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Laboratory location: Milan, Italy

Recent publications

Group members

Staff Scientist
Maspero Elena
Post Doc
Menin Luca
Nino Suarez Carlos Alberto
Scotto di Perrotolo Rossella
PhD Student
Corbellini Margherita
Maestrini Giorgia
Taibi Vincenzo
Former Lab members
Sicari Daria (Assistant Scientific Direction, Pharma Line srl, Milan)
Magistrati Elisa (Post-doc, Turco lab, FMI, Basel)
Fajner Valentina (Scientific supervisor, Fondazione Umberto Veronesi, Milan)
Oltrabella Francesca (Medical Scientific Liaison at Astellas, Milan)
Biancospino Matteo (Medical Science Liaison, Janssen, Milan)
Valentini Eleonora (Quality Assurance Assistant, Sintetica SA, Mendrisio)
Savio Michol (Medical Science Manager, Bristol-Myers Squibb, Turin)
Wollscheid Hans-Peter (Post-doc, Ulrich lab, IMB, Mainz)
Wossner Nadine (Clinical Monitor, IZKS, Mainz)
Mari Sara (Medical Science Liaison presso Janssen, Milan)
Maruwge Wessen (Grant Writer, IFOM, Milan)
Acconcia Filippo (Associate Professor, Università Roma Tre, Rome)
Penengo Lorenza (Associate Professor,University of Zurich)
Argenzio Elisabetta (Scientific Officer, Director's Office, Human Technopole)
Oldrini Barbara (Staff scientist, Squatrito Lab, CNIO, Madrid)
Woelk Bange Tanja (Project Leader, Biomedical Center Munich Molecular Biology, Munich)
Sigismund Sara (Associate Professor, Università degli Studi, Milan)

(update: Nov 2022)

IFOM Review

Deubiquitination enzymes in the limelight
Commentary on Simona Polo's paper published on Current Biology, by Yossi Yarden (2015)
Ubiquitin and SUMO: an hands-on experience... by the sea
Personal memories for a memorable EMBO Practical Course organized by Simona Polo, by Ronald T. Hay (2013)
Illuminating a ubiquitin transfer relay, step-by-step
Commentary on Simona Polo's paper published on Nature Structural & Molecular Biology, by Brenda A. Schulman (2013)
complete review

Press releases


In the press

Una fotografia molecolare per l'ubiquitina

2013.05.10 | Francesco Aiello

Tumori: italiana scatta fermo immagine di proteina factotum
Ansa Salute

2013.05.10 | Elisa Buson

Il fermo immagine della proteina multitasking
Ansa Scienza

2013.05.10 | Elisa Buson

Un gruppo di ricercatori dell'IFOM apre una nuova frontiera nello studio della trasduzione del segnale

2011.03.04 | Mario Bonaccorso

Simona Polo Promossa all'esame lavoro-famiglia

2011.03 | Cristina Conti

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