IFOM Simona Polo Lab

Simona Polo Lab

Simona Polo

Simona Polo

Simona Polo, a molecular and cell biologist expert directs the Ubiquitin and Signal Transduction research program at IFOM since 2005.
Born in Milan in 1968, Polo studied Biological Sciences at the University of Milan, under the supervision of Prof Daniela Ghisotti, graduating cum laude in 1991 and honorable mention. Her thesis on bacteriophage P4 received the price for the best thesis in genetics for 1991 from the AGI association. read more

Contact the researcher

Ubiquitin and Signal Transduction

The ubiquitin pathway regulates many biological processes and determines how cells respond to growth factors, stress and genetic damage, controlling nearly every facet of a cell’s life and death.
The covalent attachment of ubiquitin to proteins is not simply a sign of destruction but it can be a regulatory signal that alters localization, activity, and ultimate fate of the target proteins. read more

Laboratory location: Milan, Italy

Recent publications

  • Wollscheid HP, Biancospino M, He F, Magistrati E, Molteni E, Lupia M, Soffientini P, Rottner K, Cavallaro U, Pozzoli U, Mapelli M, Walters KJ, Polo S.
    Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain.
    Nat Struct Mol Biol. 2016 Apr;23(4):300-8. doi: 10.1038/nsmb.3187. Epub 2016 Mar 7.
  • He F, Wollscheid HP, Nowicka U, Biancospino M, Valentini E, Ehlinger A, Acconcia F, Magistrati E, Polo S*, Walters KJ*
    Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains.
    Cell Rep. 2016 Mar 22;14(11):2683-94. doi: 10.1016/j.celrep.2016.01.079. Epub 2016 Mar 10.
    * corresponding author
  • Savio MG, Wollscheid N, Cavallaro E, Algisi V, Di Fiore PP, Sigismund S, Maspero E, Polo S.
    USP9X Controls EGFR Fate by Deubiquitinating the Endocytic Adaptor Eps15.
    Curr Biol. 2016 Jan 25;26(2):173-83. doi: 10.1016/j.cub.2015.11.050. Epub 2015 Dec 31.

Group members

Staff Scientist
Elena Maspero
Postdoctoral fellows
Valentina Fayner
Elisa Magistrati
Luca Menin
Carlos Niño
PhD Students
Rossella Scotto di Perrottolo
Simona Sala
Undergraduate Students
Vincenzo Taibi
Temporary fellow
Ilaria De Simone
Former Lab members
Michol Savio (Medical Science Manager, Bristol-Myers Squibb, Turin)
Hans-Peter Wollscheid (Post-doc, Ulrich lab, IMB, Mainz)
Nadine Wossner (Clinical Monitor, IZKS, Mainz)
Sara Mari (Post-doc, Mapelli Lab, IEO, Milan)
Wessen Maruwge (Grant Writer, IFOM, Milan)
Filippo Acconcia (Associate Professor, Università degli Studi, Rome)
Lorenza Penengo (Group Leader at University of Zurich)
Elisabetta Argenzio (Post-doc, Moolenaar Lab, NKI, Amsterdam)
Barbara Oldrini (Staff scientist, Squatrito Lab, CNIO, Madrid)
Tanja Woelk (Post-doc, Max Planck Institute of Molecular Physiology, Dortmund)

(update: April 2019)

IFOM Review

Deubiquitination enzymes in the limelight
Commentary on Simona Polo's paper published on Current Biology, by Yossi Yarden (2015)
Ubiquitin and SUMO: an hands-on experience... by the sea
Personal memories for a memorable EMBO Practical Course organized by Simona Polo, by Ronald T. Hay (2013)
Illuminating a ubiquitin transfer relay, step-by-step
Commentary on Simona Polo's paper published on Nature Structural & Molecular Biology, by Brenda A. Schulman (2013)
complete review

Press releases


In the press

Una fotografia molecolare per l'ubiquitina

2013.05.10 | Francesco Aiello

Tumori: italiana scatta fermo immagine di proteina factotum
Ansa Salute

2013.05.10 | Elisa Buson

Il fermo immagine della proteina multitasking
Ansa Scienza

2013.05.10 | Elisa Buson

Un gruppo di ricercatori dell'IFOM apre una nuova frontiera nello studio della trasduzione del segnale

2011.03.04 | Mario Bonaccorso

Simona Polo Promossa all'esame lavoro-famiglia

2011.03 | Cristina Conti

view all press review