IFOM Vincenzo Costanzo Lab

Vincenzo Costanzo Lab

Vincenzo Costanzo

Italian, born in Naples in '73, Vincenzo Costanzo directs the DNA Metabolism research program at IFOM.
In 1998, he graduated in Medicine and Surgery at the University of Naples Federico II. His college years were crucial for laying the foundations of his scientific career. read more

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DNA Metabolism

Cells respond to DNA damage by activating a multi-faceted response called DNA damage response. Defects in this response can result in genomic instability, a major feature of cancer cells. Several cancer-prone syndromes reflect defects in the specific genes of the DNA damage response. read more

Laboratory location: Milan, Italy

Recent publications

  • Zhao Z, Oh S, Li D, Ni D, Pirooz SD, Lee JH, Yang S, Lee JY, Ghozalli I, Costanzo V, Stark JM, Liang C.
    A Dual Role for UVRAG in Maintaining Chromosomal Stability Independent of Autophagy.
    Dev Cell. 2012 May 15;22(5):1001-16. Epub 2012 Apr 26.
  • Ray Chaudhuri A, Hashimoto Y, Herrador R, Neelsen KJ, Fachinetti D, Bermejo R, Cocito A, Costanzo V, Lopes M.
    Topoisomerase I poisoning results in PARP-mediated replication fork reversal.
    Nat Struct Mol Biol. 2012 Mar 4;19(4):417-23. doi: 10.1038/nsmb.2258.
  • Errico A, Costanzo V.
    Mechanisms of replication fork protection: a safeguard for genome stability.
    Crit Rev Biochem Mol Biol. 2012 May;47(3):222-35. Epub 2012 Feb 11.

Group members

Sina Atashpazgargari
Anna De Antoni
Lucia Falbo
Federica Pezzimenti
Gabriele Piergiovanni
Erica Raspelli
Francesco Romeo
Vincenzo Sannino
Hervé Techer
Maria Vinciguerra
PhD students
Giorgio Baldi
Stefania Bertora
Arun Mouli
Sara Samadi

update: April 2015

In the press

Nobel Chimica: esperti, da studi nuovo approccio contro il cancro
AGI

2015.10.08 

La Molecola che si ripara da sola
Radio3Scienza

2015.10.08  | URL

Il Nobel ai meccanici del DNA
Il Messaggero

2015.10.08 | Carla Massi

L'origine della Microcefalia
Italiasalute

2015.07.22

Microcefalia: ecco la proteina che regola lo sviluppo del cervello
Adnkronos

2015.07.21

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