Francesca Buffa Lab
Francesca Buffa
After a Degree in Theoretical Physics from the University of Turin, in 2001 Francesca completed a PhD in Biophysics and Applied Mathematics at the Institute of Cancer Research, University of London. After this, Francesca joined the ICR, the Gray Cancer Institute and the MRC Clinical Trials Unit, London, as postdoctoral researcher in imaging and omics projects. read more
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Artificial Intelligence & Systems Biology
Our research combines artificial intelligence and systems biology techniques to decode how biological networks are rewired in a disease like cancer, where cancer cells evolve and interact within a complex and dynamic microenvironment. read more
Laboratory location: Milan, Italy
Selected peer-reviewed papers
- Barberis A, Buffa FM. Sigscores: summary scores for molecular signatures in R. Bioinfomatics Advances, 2025 (In Print) Di Giovannantonio M, Hartley F, Elshenawy B, Barberis A, Hudson D, Shafique HS, Allott VES, Harris DA, Lord SR, Haider S, Harris AL, Harris BHL - Buffa FM (co-last, co-corresponding). Defining hypoxia in cancer: A landmark evaluation of hypoxia gene expression signatures. Cell Genomics 2025 Feb 12;5(2):100764. doi: 10.1016/j.xgen.2025.100764. Epub 2025 Jan 31. PMID: 39892389; PMCID: PMC11872601.
- Taylor A, Macaulay VM, Miossec MJ, Maurya AK, Buffa FM. GeneFEAST: the pivotal, gene-centric step in functional enrichment analysis interpretation. Bioinformatics. 2025 Mar 4;41(3):btaf100. doi: 10.1093/bioinformatics/btaf100. PMID: 40037522; PMCID: PMC11919446.
- Harris BHL, Di Giovannantonio M, Zhang P, Harris DA, Lord SR, Allen NE, Maughan TS, Bryant RJ, Harris AL, Bond GL, Buffa FM (corresponding). New role of fat-free mass in cancer risk linked with genetic predisposition. Sci Rep. 2024 Mar 27;14(1):7270. doi: 10.1038/s41598-024-54291-7. PMID: 38538606; PMCID: PMC10973462.