Nils Gauthier Lab
Nils Gauthier
Nils Gauthier Joined IFOM in January 2016 to start a research group focused on Mechano-Oncology using interdisciplinary approaches to study the biophysical properties of tumor progression. Nils Gauthier started training in 2000 at the University of Nice Sophia-Antipolis in France for his PhD under the supervision of Professor Patrice Boquet. The goal of his PhD was to decipher the endocytic road of Helicobacter-pylori VacA cytotoxin into its target epithelial cells. read more
Contact the researcher
Mechano-Oncology
Our goal is to understand the roles of mechanical signals generated at the interface between membrane and cytoskeleton during tumor-associated biological events. This way of thinking about cancer is directly linked to the field of mechanobiology (i.e. the study of the role of mechanical forces in biological events) and to the lack of knowledge on the potential role of physical forces and parameters during tumor progression. read more
Recent publications
- Ghisleni A, Galli C, Monzo P, Ascione F, Fardin MA, Scita G, Li Q, Maiuri P, Gauthier NC.
Complementary mesoscale dynamics of spectrin and acto-myosin shape membrane territories during mechanoresponse.
Nat Commun. 2020 Oct 9;11(1):5108. doi: 10.1038/s41467-020-18825-7. PMID: 33037189 Free PMC article. - Barger SR, Gauthier NC, Krendel M.
Squeezing in a Meal: Myosin Functions in Phagocytosis.
Trends Cell Biol. 2020 Feb;30(2):157-167. doi: 10.1016/j.tcb.2019.11.002. Epub 2019 Dec 10. PMID: 31836280 Review. - Hetmanski JHR, de Belly H, Busnelli I, Waring T, Nair RV, Sokleva V, Dobre O, Cameron A, Gauthier N, Lamaze C, Swift J, Del Campo A, Starborg T, Zech T, Goetz JG, Paluch EK, Schwartz JM, Caswell PT.
Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration.
Dev Cell. 2019 Nov 18;51(4):460-475.e10. doi: 10.1016/j.devcel.2019.09.006. Epub 2019 Oct 10. PMID: 31607653 Free PMC article.
Group members
Scientist
Monzo PascalePost Doc
Ghisleni AndreaPhD student
Crestani MicheleDini Tania
(update: Mar 2021)
Collaboration
- MBI Singapore, Singapore Charlotte Guetta, studente PhD (codirezione con Pr Benoit Ladoux)
- IBEC Barcellona Spagna Anita Kosmalska, studente PhD (codirezione con Dottor Pere Roca-Cusachs)
- State University of New York (SUNY), Sarah Barger PhD student (collaboration with Dr Mira Krendel)
Rassegna Stampa
In laboratorio insieme ai ricercatori sono loro i futuri cervelli della scienza
2019.06.28
La Provincia di Lecco | Fabrizio Alfano