IFOM Nils Gauthier Lab

Nils Gauthier Lab

Nils Gauthier

Nils Gauthier Joined IFOM in January 2016 to start a research group focused on Mechano-Oncology using interdisciplinary approaches to study the biophysical properties of tumor progression. Nils Gauthier started training in 2000 at the University of Nice Sophia-Antipolis in France for his PhD under the supervision of Professor Patrice Boquet. The goal of his PhD was to decipher the endocytic road of Helicobacter-pylori VacA cytotoxin into its target epithelial cells.

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Our goal is to understand the roles of mechanical signals generated at the interface between membrane and cytoskeleton during tumor-associated biological events. This way of thinking about cancer is directly linked to the field of mechanobiology (i.e. the study of the role of mechanical forces in biological events) and to the lack of knowledge on the potential role of physical forces and parameters during tumor progression.

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Laboratory location: Milan, Italy

Recent publications

  • Meacci G, Wolfenson H, Liu S, Stachowiak MR, Iskratsch T, Mathur A,Ghassemi S, Gauthier N, Tabdanov E, Lohner J, Gondarenko A, Chander AC, Roca-Cusachs P, O'Shaughnessy B, Hone J, Sheetz MP.
    α-actinin links ECM rigidity sensing contractile units with periodic cell edge retractions.
    Mol Biol Cell. 2016 Apr 27.
  • Masters TA*, Sheetz MP, Gauthier NC*.
    F-actin waves, actin cortex disassembly and focal exocytosis driven by actin-phosphoinositide positive feedback.
    Cytoskeleton. 2016 Apr;73(4):180-96.
    * Corresponding authors
  • Monzo P, Chong YK, Guetta-Terrier C, Krishnasamy A, Sathe SR, Yim EK, Ng WH, Ang BT, Tang C, Ladoux B, Gauthier NC, Sheetz MP.
    Mechanical confinement triggers glioma linear migration dependent on formin FHOD3.
    Mol Biol Cell. 2016 Apr 15;27(8):1246-61

Group members

Research Scientist
Dr Pascale Monzo
PhD students
Camilla Galli

(update: June 2016)