Giannino Del Sal Lab

Giannino Del Sal

Giannino Del Sal studied biology at the University of Trieste and had his research training at the International Centre for Genetic Engineering and Biotechnology (ICGEB) in Trieste (Italy), at the European Molecular Biology Laboratory (EMBL) in Heidelberg (Germany) working with Claudio Schneider, and at LNCIB in Trieste where since 1996 he has been Head of the Molecular Oncology Unit.

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Signalling, tumor environment and cell metabolism

This research program stems from the long lasting experience of Giannino Del Sal in the field of cancer biology, particularly in the study of the wild-type p53/mutant p53 molecular networks, and from several breakthrough discoveries he made on these pathways. p53 is a tumour suppressor and it regulates almost every facet of cell behaviour.

Laboratory location: Trieste, Italy

Last publications

Napoletano, F., Ferrari Bravo, G., Voto, I.A.P., Santin, S., Celora, L., Campaner, E., Dezi, C., Bertossi, A., Valentino, E., Santorsola, M., Rustighi, A., Fajner, V., Maspero, E., Ansaloni, F., Cancila, V., Valenti, C.F., Santo, M., Artimagnella, O.B., Finaurini, S., Gioia, U., Polo, S., Sanges, R., Tripodo, C., Mallamaci, A., Gustincich, S., d’Adda di Fagagna, F., Mantovani, F., Specchia, V., Del Sal, G. (2021).
The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.
Cell Reports 36, 109694.

Valeria Capaci, Lorenzo Bascetta, Marco Fantuz, Galina V Beznoussenko, Roberta Sommaggio, Valeria Cancila, Andrea Bisso, Elena Campaner, Alexander A Mironov, Jacek R Wiśniewski, Luisa Ulloa Severino, Denis Scaini, Fleur Bossi, Jodi Lees, Noa Alon, Ledia Brunga, David Malkin, Silvano Piazza, Licio Collavin, Antonio Rosato, Silvio Bicciato, Claudio Tripodo, Fiamma Mantovani, Giannino Del Sal
Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome
Nat Commun. 2020 Aug 7;11(1):3945. doi: 10.1038/s41467-020-17596-5.

Fiamma Mantovani, Licio Collavin, Giannino Del Sal
Mutant p53 as a guardian of the cancer cell
Cell Death and Differentiantion 26,199-212 doi: /doi.org/10.1038/s41418-018-0246-9 (2019)

Rebecca Bertolio, Francesco Napoletano, Miguel Mano, Sebastian Maurer-Stroh, Marco Fantuz, Alessandro Zannini, Silvio Bicciato, Giovanni Sorrentino, Giannino Del Sal
Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
Nature Communications 10, Article number: 1326 (2019)

Caroli J, Sorrentino G, Forcato M, Del Sal G, Bicciato S. (2018)
GDA, a web-based tool for Genomics and Drugs integrated analysis.
Nucleic Acids Res.46(W1): W148-W156.doi: 10.1093/nar/gky434.

Ingallina E, Sorrentino G, Bertolio R, Lisek K, Zannini A, Azzolin L, Severino LU, Scaini D, Mano M, Mantovani F, Rosato A, Bicciato S, Piccolo S, Del Sal G. (2018)
Mechanical cues control mutant p53 stability through a mevalonate-RhoA axis.
Nat Cell Biol. 20(1):28-35. doi: 10.1038/s41556-017-0009-8.
Liao P, Zeng SX, Zhou X, Chen T, Zhou F, Cao B, Jung JH, Del Sal G, Luo S, Lu H. (2017)
Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding.
Mol Cell. 68(6):1134-1146.e6. doi: 10.1016/j.molcel.2017.11.006.