IFOM Marco Foiani Lab

Marco Foiani Lab

Marco Foiani

Marco Foiani is Professor of Molecular Biology at the University of Milan and, since 2009, Scientific Director of IFOM, an international cancer center that hosts 20 groups and 300 scientists. Two research groups are operating in IFOM outstations located in Singapore (at ASTAR-p53 Laboratory and at the Mechano Biology Institute of NUS) and one in Bangalore, India, (at inSTEM & NCBS). read more

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Genome Integrity

ATR (Mec1 in yeast) mediates the DNA damage response (DDR) (Jackson and Bartek, 2009), together with ATM (Tel1 in yeast), Chk1 and Chk2 (Rad53 in yeast). Checkpoint genes are often mutated in cancer cells and the DDR represents an anti cancer barrier in response to oncogenic stimuli (Halazonetis et al., 2008). read more

Laboratory location: Milan, Italy

Recent publications

  • Awasthi P, Foiani M, Kumar A.
    ATM and ATR signaling at a glance.
    J Cell Sci. 2015 Dec 1;128(23):4255-62.
  • Rossi SE, Ajazi A, Carotenuto W, Foiani M, Giannattasio M.
    Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress.
    Cell Rep. 2015 Oct 6;13(1):80-92
  • Gay S, Foiani M.
    Nuclear envelope and chromatin, lock and key of genome integrity.
    Int Rev Cell Mol Biol. 2015; 317:267-330.

Group members

Achar Yathish Jagadheesh
Arakawa Hiroshi
Bruhn Christopher
Ferrari Elisa
Gay Sophie
Giannattasio Michele
Kosar Martin
Li Qingsen
Lucca Chiara
Piccini Daniele
Shubassi Ghadeer
Singh Pawan
PhD students
Ajazi Arta
Bastianello Giulia
Choudhary Ramveer
Kidiyoor Gururaj Rao
Rossi Silvia Emma

IFOM Review

"An entirely new perspective in which chromosomes are considered as mechanical objects"
Commentary on Marco Foiani's paper published in Cell, by Nancy Kleckner (2015)
The role of senataxin in cancer and ALS
Commentary on Marco Foiani and Giordano Liberi's paper published on Cell, by Giuseppe Biamonti (2013)
complete review

In the press

Il Nobel che guida la ricerca sul DNA anche a Milano
Il Corriere della Sera

2015.10.08 | Giovanni Caprara

Parla milanese il Nobel Lindahl, è presidente del comitato Ifom
Il Corriere della Sera - ed On Line

2015.10.07 | Giovanni Caprara | URL

AIRC festeggia il mezzo secolo con l'anno record della ricerca
Il Corriere della Sera - Ed. Milano

2015-07-24 | Giovanni Caprara

Il diapason che sente vibrare le cellule e le rende plastiche


Una proteina diapason dona plasticità alle cellule
Ansa - Scienza e Tecnica


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