Fabrizio d'Adda di Fagagna Lab

Fabrizio d'Adda di Fagagna

Fabrizio d'Adda di Fagagna, Ph.D. is a cell and molecular biologist that studies the involvement of the DNA damage response (DDR) pathways in physiologically-relevant processes such as aging and cancer.
Fabrizio studied Biology at the University of Trieste and obtained his Ph.D. in Molecular Genetics at SISSA, the International School for Advanced Studies, in Trieste, Italy, while working at ICGEB (International Centre for Genetic Engineering and Biotechnology) under the guidance of Mauro Giacca and Arturo Falaschi. read more

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DNA Damage Response and Cellular Senescence

We study the physiological consequences of DNA damage at the cellular and organismal level mainly in mammals. Nuclear DNA damage triggers a signaling and effector pathway known as the DNA damage response (DDR) that coordinates cell-cycle arrest (checkpoint functions) and DNA repair. read more about the program

Laboratory location: Milan, Italy

Recent publications

Nicola Marino, Matteo Fiore, Aureliano Stingi, Andrea Cipriano, Antonella Santuccione Chadha, Camillo Ricordi, David Della-Morte, Fabrizio d’Adda di Fagagna, Marco Demaria, Marco Quarta, Vittorio Sebastiano, Luigi Ferrucci, Ennio Tasciotti
Towards integration of healthspan strategies into the Italian National Health Service
Aging (Albany NY). 2026 Jul 16;18(1):854-867. doi: 10.18632/aging.206402. Epub 2026 Jul 16.
Alessia Oppezzo, Sara Sepe, Giada Cicio, Valeria Cancila, Emanuele Sasso, Anastasia Conti, Eugenia Marinelli, Matteo Cabrini, Rani Pallavi, Nicola Iacomino, Matilde Simoni, Dmitrii Malyshev, Sara Boggio, Alessia di Lillo, Ilaria Rosso, Sara Tavella, Lucrezia A. Trastus, Francesca Rossiello, Giulia Roscia, Paolo Cantaloni, Alessandro Manenti, Paola Cavalcante, Pier Giuseppe Pelicci, Raffaella Di Micco, Fabrizio d’Adda di Fagagna
Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging
Commun Nat Aging. 2026 Jun 30. doi: 10.1038/s43587-026-01136-9. Online ahead of print.
Inhibition of telomere damage signaling restores hematopoiesis and immune function
Commun Nat Aging. 2026 Jun 30. doi: 10.1038/s43587-026-01146-7. Online ahead of print.
Alessia di Lillo, Sara Tavella, Fabio Iannelli, Giovanni Crisafulli, Ubaldo Gioia, Lucrezia A Trastus, Matteo Cabrini, Fabrizio d'Adda di Fagagna
Site-specific DNA double-strand break induces local transcription in cis and protein expression
Commun Biol. 2026 May 19. doi: 10.1038/s42003-026-10230-y. Online ahead of print.
Enrico Berrino, Sara Erika Bellomo, Maria Costanza Aquilano, Marta Falcinelli, Anita Chesta, Emanuele Valtorta, Daniela Zampieri, Gianluca Mauri, Giuseppe Sala, Silvia Marsoni, Alberto Bardelli, Andrea Sartore-Bianchi, Salvatore Siena, Anna Sapino, Emanuela Bonoldi, Fabrizio d’Adda di Fagagna, Caterina Marchiò
Degrees of H2AX phosphorylation correlate with unique features of the intratumoral immune microenvironment in colorectal carcinomas
Oncologist . 2026 Apr 10;31(5):oyag116. doi: 10.1093/oncolo/oyag116.

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Group members

Guest researcher

Sofia Francia
Luca Tagliafico

PhD Student SEMM

Chiara Casirati
Giacomo Graziano

Post Doc

Alexandra Mancheno Ferris
Federica Rey
Matilde Simoni
Federica Terraneo
Lucrezia Trastus

Staff Scientist

Francesca Rossiello
Sara Sepe

Technician

Eugenia Marinelli

Former members

Alessia Oppezzo
Matteo Cabrini
Marta Falcinelli
Giada Lucia Cicio
Oscar Sapkota
Marta Ceccon
Okita Akiko
Alessia Di Lillo
Ilaria Rosso
Anna De Polo (Postdoc at Italian Institute of Technology - IIT, Milan, Italy)
Matilde Conte
Giulia Dell’Omo (Roche)
Valentina Matti
Corey Jones-Weinert (Postdoctoral fellow at Salk Institute for Biological Studies, California)
Sofia Francia (Resarcher at IGM-CNR, Pavia)
Ubaldo Gioia (Resarcher at IGM-CNR, Pavia)
Sara Boggio
Ana Cristina Do Espirito Santo Henriques
Flavia Michelini (Associate Director Astrazeneca)
Marek Adamowicz (Postdoc at University of Sussex, Brighton, UK)
Julio Aguado (Postdoc at the Australian Institute for Bioengineering
and Nanotechnology,
University of Queensland - Brisbane, Australia)
Aurora Cerutti (Senior Scientist at Artios Pharma, Cambridge UK)
Giuseppina D'Alessandro (Postdoc at the University of Cambridge)
Raffaella Di Micco (Principal Investigator at San Raffaele Telethon Institute for Gene Therapy)
Miriana Dobreva (Sanofi)
Matteo Formenti (Technician at Ludwig Institute for Cancer Research, Brussels, Belgium)
Marzia Fumagalli (Head of Technology Transfer Office at IEO)
Alessandro Galbiati (Senior Scientist II - Team Leader Cell based assay development and screening at Artios)
Fabio Iannelli (Bioinformatician at IFOM)
Muege Ogrunc (CSO at Stark Labs)
Fabio Pessina (Senior Research Technician at Human Technopole)
Leonid Schneider
Marie Sgandurra (Lab scientist, Université de Lausanne, CH)
Sheetal Sharma (Assistant Professor, Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Sciences, Chandigarh, India )
Lucia Spath (Italian Coast Guard Officer)
Gabriele Sulli (Assistant Professor, Scintillon Institute, San Diego California)
Jelena Vermezovic (Postdoc in IFOM)
Valerio Vitelli

(update: Apr 2026)