Fabrizio d'Adda di Fagagna Lab

Fabrizio d'Adda di Fagagna

Fabrizio d'Adda di Fagagna, Ph.D. is a cell and molecular biologist that studies the involvement of the DNA damage response (DDR) pathways in physiologically-relevant processes such as aging and cancer.
Fabrizio studied Biology at the University of Trieste and obtained his Ph.D. in Molecular Genetics at SISSA, the International School for Advanced Studies, in Trieste, Italy, while working at ICGEB (International Centre for Genetic Engineering and Biotechnology) under the guidance of Mauro Giacca and Arturo Falaschi. read more

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DNA Damage Response and Cellular Senescence

We study the physiological consequences of DNA damage at the cellular and organismal level mainly in mammals. Nuclear DNA damage triggers a signaling and effector pathway known as the DNA damage response (DDR) that coordinates cell-cycle arrest (checkpoint functions) and DNA repair. read more about the program

Laboratory location: Milan, Italy

Recent publications

Ubaldo Gioia, Sara Tavella, Pamela Martínez-Orellana, Giada Cicio, Andrea Colliva, Marta Ceccon, Matteo Cabrini, Ana C Henriques, Valeria Fumagalli, Alessia Paldino, Ettore Presot, Sreejith Rajasekharan, Nicola Iacomino, Federica Pisati, Valentina Matti, Sara Sepe, Matilde Conte, Sara Barozz, Zeno Lavagnino, Tea Carletti, Maria Concetta Volpe, Paola Cavalcante, Matteo Iannacone, Chiara Rampazzo, Rossana Bussani, Claudio Tripodo, Serena Zacchigna, Alessandro Marcello, Fabrizio d'Adda di Fagagna
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
Nat Cell Biol. 2023 Mar 9. doi: 10.1038/s41556-023-01096-x. Online ahead of print.

Marta Falcinelli, Giulia Dell’Omo, Elena Grassi, Elisa Mariella, Simonetta Maria Leto, Sharon Scardellato, Annalisa Lorenzato, Sabrina Arena, Andrea Bertotti, Livio Trusolino, Alberto Bardelli & Fabrizio d’Adda di Fagagna
Colorectal cancer patient-derived organoids and cell lines harboring ATRX and/or DAXX mutations lack Alternative Lengthening of Telomeres (ALT)
Cell Death & Disease volume 14, Article number: 96 (2023)

Frittoli E, Palamidessi A, Iannelli F, Zanardi F, Villa S, Barzaghi L, Abdo H, Cancila V, Beznoussenko GV, Della Chiara G, Pagani M, Malinverno C, Bhattacharya D, Pisati F, Yu W, Galimberti V, Bonizzi G, Martini E, Mironov AA, Gioia U, Ascione F, Li Q, Havas K, Magni S, Lavagnino Z, Pennacchio FA, Maiuri P, Caponi S, Mattarelli M, Martino S, d'Adda di Fagagna F, Rossi C, Lucioni M, Tancredi R, Pedrazzoli P, Vecchione A, Petrini C, Ferrari F, Lanzuolo C, Bertalot G, Nader G, Foiani M, Piel M, Cerbino R, Giavazzi F, Tripodo C, Scita G.
Tissue fluidification promotes a cGAS–STING cytosolic DNA response in invasive breast cancer
Nat Mater. 2023 May;22(5):644-655. doi: 10.1038/s41563-022-01431-x. Epub 2022 Dec 29.

Valentina Buemi, Odessa Schillaci, Mariangela Santorsola, Deborah Bonazza, Pamela Veneziano Broccia, Annie Zappone, Cristina Bottin, Giulia Dell’Omo, Sylvie Kengne, Stefano Cacchione, Grazia Daniela Raffa, Silvano Piazza, Fabrizio d’Adda di Fagagna, Roberta Benetti, Maurizio Cortale, Fabrizio Zanconati, Giannino Del Sal & Stefan Schoeftner
TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance
Nature Communications volume 13, Article number: 2302 (2022)

Francesca Rossiello, Diana Jurk, João F. Passos & Fabrizio d’Adda di Fagagna
Telomere dysfunction in ageing and age-related diseases
Nature Cell Biology volume 24, pages 135–147 (2022)

Dan Chen, Judit Z. Gervai, Ádám Póti, Eszter Németh, Zoltán Szeltner, Bernadett Szikriszt, Zsolt Gyüre, Judit Zámborszky, Marta Ceccon, Fabrizio d’Adda di Fagagna, Zoltan Szallasi, Andrea L. Richardson& Dávid Szüts
BRCA1 deficiency specific base substitution mutagenesis is dependent on translesion synthesis and regulated by 53BP1
Nat Commun 13, 226 (2022). doi: 10.1038/s41467-021-27872-7

complete list PubMed Google Scholar F1000

Group members

Staff Scientist

Rossiello Francesca
Sepe Sara

Post Doc

Cabrini Matteo
Ceccon Marta
Di Lillo Alessia
Falcinelli Marta
Mancheno Ferris Alexandra
Okita Akiko
Oppezzo Alessia
Tavella Sara

PhD Student

Rosso Ilaria
Sapkota Oscar
Trastus Lucrezia

Guest researcher

Eugenia Marinelli

Research Tecnichian Fellow

Cicio Giada Lucia

Former members

Anna De Polo (Postdoc at Italian Institute of Technology - IIT, Milan, Italy)
Matilde Conte
Giulia Dell’Omo (Roche)
Valentina Matti
Corey Jones-Weinert (Postdoctoral fellow at Salk Institute for Biological Studies, California)
Sofia Francia (Resarcher at IGM-CNR, Pavia)
Ubaldo Gioia (Resarcher at IGM-CNR, Pavia)
Sara Boggio
Do Espirito Santo Henriques Ana Cristina
Flavia Michelini (Associate Director Astrazeneca)
Marek Adamowicz (Postdoc at University of Sussex, Brighton, UK)
Julio Aguado (Postdoc at the Australian Institute for Bioengineering
and Nanotechnology,
University of Queensland - Brisbane, Australia)
Aurora Cerutti (Senior Scientist at Artios Pharma, Cambridge UK)
Giuseppina D'Alessandro (Postdoc at the University of Cambridge)
Raffaella Di Micco (Principal Investigator at San Raffaele Telethon Institute for Gene Therapy)
Miriana Dobreva (Sanofi)
Matteo Formenti (Technician at Ludwig Institute for Cancer Research, Brussels, Belgium)
Marzia Fumagalli (Head of Technology Transfer Office at IEO)
Alessandro Galbiati (Senior Scientist II - Team Leader Cell based assay development and screening at Artios)
Fabio Iannelli (Bioinformatician at IFOM)
Muege Ogrunc (CSO at Stark Labs)
Fabio Pessina (Senior Research Technician at Human Technopole)
Leonid Schneider
Marie Sgandurra (Lab scientist, Université de Lausanne, CH)
Sheetal Sharma (Assistant Professor, Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Sciences, Chandigarh, India )
Lucia Spath (Italian Coast Guard Officer)
Gabriele Sulli (Assistant Professor, Scintillon Institute, San Diego California)
Jelena Vermezovic (Postdoc in IFOM)
Valerio Vitelli

(update: Mar 2023)