Denis Schapiro Lab
Denis Schapiro
Dr. Denis Schapiro is an IFOM Group Leader, Managing Director of the Translational Spatial Profiling Center (TSPC) and Research Group Leader at the Medical Faculty of the Heidelberg University focusing on spatial omics technologies and analysis. He is also co-founder and the current president of the European Society for Spatial Biology (ESSB) e.V.
read more
Tumor Spatial Biology
Our research focuses on the development and application of spatially resolved (single-cell) technologies to understand how tumors evolve, evade immune control, and respond to therapy. Cancer is not only a genetic disease but an ecological system of malignant, stromal, and immune cells interacting in space.
read more
Previous publications
Spatial multiomics of acute myocardial infarction reveals immune cell infiltration through the endocardium
Florian Wünnemann, Florian Sicklinger, Kresimir Bestak, Jose Nimo, Tobias Thiemann, Junedh M Amrute, Mathias Nordbeck, Niklas Hartmann, Miguel A Ibarra-Arellano, Jovan Tanevski, Margot Chazotte, Clara Heine, Norbert Frey, Kory J Lavine, Fabian Coscia, Julio Saez-Rodriguez, Florian Leuschner, Denis Schapiro
Nat Cardiovasc Res. 2025 Oct;4(10):1345-1362. doi: 10.1038/s44161-025-00717-y. Epub 2025 Oct 3.
MCMICRO: a scalable, modular image-processing pipeline for multiplexed tissue imaging
Denis Schapiro, Artem Sokolov, Clarence Yapp, Yu-An Chen, Jeremy L Muhlich, Joshua Hess, Allison L Creason, Ajit J Nirmal, Gregory J Baker, Maulik K Nariya, Jia-Ren Lin, Zoltan Maliga, Connor A Jacobson, Matthew W Hodgman, Juha Ruokonen, Samouil L Farhi, Domenic Abbondanza, Eliot T McKinley, Daniel Persson, Courtney Betts, Shamilene Sivagnanam, Aviv Regev, Jeremy Goecks, Robert J Coffey, Lisa M Coussens, Sandro Santagata, Peter K Sorger
Nat Methods. 2022 Mar;19(3):311-315. doi: 10.1038/s41592-021-01308-y. Epub 2021 Nov 25.
histoCAT: analysis of cell phenotypes and interactions in multiplex image cytometry data
Denis Schapiro, Hartland W Jackson, Swetha Raghuraman, Jana R Fischer, Vito R T Zanotelli, Daniel Schulz, Charlotte Giesen, Raúl Catena, Zsuzsanna Varga, Bernd Bodenmiller
Nat Methods. 2017 Sep;14(9):873-876. doi: 10.1038/nmeth.4391. Epub 2017 Aug 7.