IFOM Fabrizio d'Adda di Fagagna

Fabrizio d'Adda di Fagagna

Fabrizio d'Adda di Fagagna, a cell biologist expert in the study of cellular aging processes, directs the DNA damage Response and Cellular Senescence research program at IFOM.

Born in Udine in 1966, d'Adda di Fagagna studied Biology at the University of Trieste, where he graduated in 1990.

In 1995, he obtained a Ph.D. in Molecular Genetics at SISSA, the International School for Advanced Studies, in Trieste.

His undergraduate and doctorate research theses both focused on the study of HIV and transcription of viral genes, and were conducted at the ICGEB (International Centre for Genetic Engineering and Biotechnology) under the guidance of Mauro Giacca and Arturo Falaschi.

From 1996 to 2003 he conducted postdoctoral research at the Gurdon Institute at the University of Cambridge in the laboratory of Steve Jackson, a brilliant young British scientist who studies the cellular events that follow the generation of DNA damage. Here d'Adda di Fagagna made several discoveries regarding chromosome stability and cellular aging.

In that period, the IFOM was founded in Italy and d'Adda di Fagagna was invited to visit the new Center and present the results and prospects of his research.

d'Adda di Fagagna discovered the molecular mechanism responsible for the arrest of proliferation associated with cellular senescence as it occurs under normal conditions in the life of a cell.

Thus, his work opens interesting prospects for cancer research.

d'Adda di Fagagna left Cambridge in 2003 with the aim of studying this process in cancer, and became a part of IFOM, where he established the research program that he currently directs.

The scientist has earned several international awards and prizes and authored over 30 scientific articles published in the most prestigious international journals, such as Nature, Nature Cell Biology and Nature Genetics.

In 2012 he was appointed a member of the EMBO, the prestigious European Organization for Molecular Biology.

Also starting in 2012, he became a Researcher at the CNR in Pavia, where he directs a laboratory devoted to studying the maintenance of genomic stability.