Fabrizio d'Adda di Fagagna Lab

Fabrizio d'Adda di Fagagna

Biologo cellulare esperto nello studio dei processi di invecchiamento delle cellule, Fabrizio d'Adda di Fagagna dirige all'IFOM l'unità di ricerca Risposta al danno al DNA e senescenza cellulare.
Nato a Udine nel 1966, d'Adda di Fagagna studia Biologia all'Università di Trieste, dove si laurea nel 1990.
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Risposta al danno al DNA e senescenza cellulare

Risposta al danno al DNA e senescenza cellulare è un programma di ricerca IFOM coordinato da Fabrizio d'Adda di Fagagna e dedicato allo studio dell'invecchiamento cellulare come barriera contro il cancro.
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Sede Laboratorio: Milano, Italia

Pubblicazioni recenti

Enrico Berrino, Sara Erika Bellomo, Maria Costanza Aquilano, Marta Falcinelli, Anita Chesta, Emanuele Valtorta, Daniela Zampieri, Gianluca Mauri, Giuseppe Sala, Silvia Marsoni, Alberto Bardelli, Andrea Sartore-Bianchi, Salvatore Siena, Anna Sapino, Emanuela Bonoldi, Fabrizio d’Adda di Fagagna, Caterina Marchiò
Degrees of H2AX phosphorylation correlate with unique features of the intratumoral immune microenvironment in colorectal carcinomas
Oncologist . 2026 Apr 10;31(5):oyag116. doi: 10.1093/oncolo/oyag116.
Aleksandr Dekan, Sierra Lore, Ye Eun Yoon, Aisyah Sjöholm, Alexander Tyshkovskiy, Alexey Terskikh, Ana Maria Cuervo, Anastasia Georgievskaya, Andrea Heinz, Andrei Seluanov, Andrew Adams, Andy P Tsai, Anna Murray, Anne Brunet, Anne Marije van Harten, Avi Spier, Ben Shenhar, Bente Klarlund Pedersen, Berthil Clasen, Björn Schumacher, Brian K Kennedy, Charlotte Suetta, Christiane Volbracht, Christoph Kuppe, Clive Cookson, Collin Y Ewald, Cristiana Banila, Daisy Cai, Dario Riccardo Valenzano, Dudley W Lamming, Edward Rudnic, Elias Bou Samra, Emma Teeling, Eric Verdin, Evandro Fei Fang, Fabrizio d'Adda di Fagagna, Fedor Galkin, Garri Zmudze, Heinrich Jasper, In Hwa Jang, Jing-Dong Jackie Han, Jamie Justice, Jan H J Hoeijmakers, Javier María Peralta Ramos, Jean-Marc Lemaitre, Jeroen Aerssens, Joe Betts-LaCroix, John C Newman, Juan Carlos Izpisua Belmonte, Kazuto Kawamura, Kennedy Matsagas Schaal, Kitsu Egerton, Kotb Abdelmohsen, Kristen Fortney, Lars Hartenstein, Laura Niedernhofer, Lida Katsimpardi, Lisa Melton, Lotte Bjerre Knudsen, Luigi Ferrucci, Lykke Sylow, Marco Demaria, Marissa J Schafer, Marta Guasch-Ferré, Martin Borch-Jensen, Maxim Kholin, Michael Antonov, Michael Levitt, Michela Deleidi, Miriam Merad, Morten Meldal, Mourad Topors, Murali Venkatesan, Nathan K LeBrasseur, Niklas Anzinger, Peter Fedichev, Paul Kohlhaas, Peter J Mullen, Priya Singhal, Rafael de Cabo, Riekelt H Houtkooper, Rusty Montgomery, Ryan Smith, Sharon Rosenzweig-Lipson, Sergey Jakimov, Steve Horvath, Steven Austad, Thomas A Rando, Todd White, Tom Zuber, Tomaz Rozmaric, Tony Wyss-Coray, Tuomas Tammela, Vadim N Gladyshev, Vanessa V C Sinatti, Weilan Wang, William Harborne, Xiaodong Liu, Xing Li Wang, Yousin Suh, Yuta Lee, Zane Koch, Alex Zhavoronkov, Morten Scheibye-Knudsen, Daniela Bakula
Toward actionable interventions in human aging (12th ARDD meeting, 2025)
Aging (Albany NY). 2026 Apr 6;18(1):282-302. doi: 10.18632/aging.206368. Online ahead of print.
Daniel H Nussey, Fabrizio d'Adda di Fagagna, Allison J Bardin, Helen Blau, Anne Brunet, Dmitry V Bulavin, Longhua Guo, Eiji Hara, Jan Philipp Junker, Vera Gorbunova, Maria Mittelbrunn, Michael Rera, Jane Reznick, Andrei Seluanov, Björn Schumacher, Emma C Teeling, Dario Riccardo Valenzano, Jing Ye, Maximina H Yun, George A Garinis, Eric Gilson
Molecular evolution of animal aging
EMBO J. 2026 Apr;45(7):2095-2111. doi: 10.1038/s44318-026-00725-z. Epub 2026 Feb 27.
Daniele Vignoli, Marco Albertini, Carlos Chiatti, Gianluca Aimaretti, Giovanna Boccuzzo, Vanna Boffo, Agar Brugiavini, Filippo Cavallo, Simone Cenci, Antonio Cherubini, Febo Cincotti, Fabrizio d'Adda di Fagagna, Carlo Ferrarese, Vincenzo Galasso, Elisabetta Galeotti, Andrea Graziani, Guido Iaccarino, Fabrizia Lattanzio, Claudio Lucifora, Mario Mezzanzanica, Giuseppe Passarino, Anna Paterno, Sabrina Prati, Raffaella I Rumiati, Marco Sandri, Cecilia Tomassini, Alexandra Torbica, Andrea Ungar, Alessandra Petrucci
Aging well in an aging society: Italy at the forefront of global aging and the Age-It Research Program
J Gerontol B Psychol Sci Soc Sci. 2025 Dec 1;80(Supplement_2):S99-S109. doi: 10.1093/geronb/gbaf219.
Fabrizio Chiti, Fiorenzo Conti, Daniela Corda, Francesco Giorgino, Andrea Graziani, Giuseppe Passarino, Marco Sandri, Fabrizio d'Adda di Fagagna
Improving our understanding of the biology of aging: findings from the Age-It Research Program
J Gerontol B Psychol Sci Soc Sci. 2025 Dec 1;80(Supplement_2):S122-S135. doi: 10.1093/geronb/gbaf197.
Francesca Esposito, Ilaria Capozzo, Adelaide Riccardi, Ubaldo Gioia, Stefania Modafferi, Letizia Manfredi, Alessio Colantoni, Sara Tavella, Matteo Cabrini, Fabio Iannelli, Alessia di Lillo, Fabrizio d'Adda di Fagagna, Sofia Francia
DROSHA, DICER, and damage-induced long ncRNA control BMI1-dependent transcriptional repression at DNA double-strand break
Cell Rep. 2025 Dec 3;44(12):116605. doi: 10.1016/j.celrep.2025.116605. Online ahead of print.

Lista completa PubMed Google Scholar F1000

Membri del grupppo

Guest researcher

Sofia Francia
Luca Tagliafico

PhD Student SEMM

Chiara Casirati
Giacomo Graziano

Post Doc

Alexandra Mancheno Ferris
Federica Rey
Matilde Simoni
Federica Terraneo
Lucrezia Trastus

Staff Scientist

Francesca Rossiello
Sara Sepe

Technician

Eugenia Marinelli

Former members

Alessia Oppezzo
Matteo Cabrini
Marta Falcinelli
Giada Lucia Cicio
Oscar Sapkota
Marta Ceccon
Okita Akiko
Alessia Di Lillo
Ilaria Rosso
Anna De Polo (Postdoc at Italian Institute of Technology - IIT, Milan, Italy)
Matilde Conte
Giulia Dell’Omo (Roche)
Valentina Matti
Corey Jones-Weinert (Postdoctoral fellow at Salk Institute for Biological Studies, California)
Sofia Francia (Resarcher at IGM-CNR, Pavia)
Ubaldo Gioia (Resarcher at IGM-CNR, Pavia)
Sara Boggio
Ana Cristina Do Espirito Santo Henriques
Flavia Michelini (Associate Director Astrazeneca)
Marek Adamowicz (Postdoc at University of Sussex, Brighton, UK)
Julio Aguado (Postdoc at the Australian Institute for Bioengineering
and Nanotechnology,
University of Queensland - Brisbane, Australia)
Aurora Cerutti (Senior Scientist at Artios Pharma, Cambridge UK)
Giuseppina D'Alessandro (Postdoc at the University of Cambridge)
Raffaella Di Micco (Principal Investigator at San Raffaele Telethon Institute for Gene Therapy)
Miriana Dobreva (Sanofi)
Matteo Formenti (Technician at Ludwig Institute for Cancer Research, Brussels, Belgium)
Marzia Fumagalli (Head of Technology Transfer Office at IEO)
Alessandro Galbiati (Senior Scientist II - Team Leader Cell based assay development and screening at Artios)
Fabio Iannelli (Bioinformatician at IFOM)
Muege Ogrunc (CSO at Stark Labs)
Fabio Pessina (Senior Research Technician at Human Technopole)
Leonid Schneider
Marie Sgandurra (Lab scientist, Université de Lausanne, CH)
Sheetal Sharma (Assistant Professor, Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Sciences, Chandigarh, India )
Lucia Spath (Italian Coast Guard Officer)
Gabriele Sulli (Assistant Professor, Scintillon Institute, San Diego California)
Jelena Vermezovic (Postdoc in IFOM)
Valerio Vitelli

(update: Apr 2026)