IFOM Publications Elisabetta Dejana

Publications Elisabetta Dejana

  1. Cottarelli A, Corada M, Beznoussenko GV, Mironov AA, Globisch MA, Biswas S, Huang H, Dimberg A, Magnusson PU, Agalliu D, Lampugnani MG, Dejana E.
    Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/β-catenin signaling.
    Development. 2020 Aug 24;147(16):dev185140. doi: 10.1242/dev.185140. PMID: 32747434; PMCID: PMC7473640.

  2. Kakogiannos N, Ferrari L, Giampietro C, Scalise AA, Maderna C, Ravà M, Taddei A, Lampugnani MG, Pisati F, Malinverno M, Martini E, Costa I, Lupia M, Cavallaro U, Beznoussenko GV, Mironov AA, Fernandes B, Rudini N, Dejana E, Giannotta M.
    JAM-A Acts via C/EBP-α to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function.
    Circ Res. 2020 Sep 25;127(8):1056-1073. doi: 10.1161/CIRCRESAHA.120.316742. Epub 2020 Jul 15. PMID: 32673519; PMCID: PMC7508279.

  3. Lanfranconi S, Scola E, Bertani GA, Zarino B, Pallini R, d'Alessandris G, Mazzon E, Marino S, Carriero MR, Scelzo E, Faragò G, Castori M, Fusco C, Petracca A, d'Agruma L, Tassi L, d'Orio P, Lampugnani MG, Nicolis EB, Vasamì A, Novelli D, Torri V, Meessen JMTA, Al-Shahi Salman R, Dejana E, Latini R; Treat- CCM Investigators.
    Propranolol for familial cerebral cavernous malformation (Treat_CCM): study protocol for a randomized controlled pilot trial
    Trials. 2020 May 12;21(1):401. doi: 10.1186/s13063-020-4202-x. PMID: 32398113; PMCID: PMC7218540.

  4. Martowicz A, Trusohamn M, Jensen N, Wisniewska-Kruk J, Corada M, Ning FC, Kele J, Dejana E, Nyqvist D.
    Endothelial β-Catenin Signaling Supports Postnatal Brain and Retinal Angiogenesis by Promoting Sprouting, Tip Cell Formation, and VEGFR (Vascular Endothelial Growth Factor Receptor) 2 Expression
    Arterioscler Thromb Vasc Biol. 2019 Nov;39(11):2273-2288. doi: 10.1161/ATVBAHA.119.312749. Epub 2019 Sep 19. PMID: 31533473.

  5. Malinverno M, Maderna C, Abu Taha A, Corada M, Orsenigo F, Valentino M, Pisati F, Fusco C, Graziano P, Giannotta M, Yu QC, Zeng YA, Lampugnani MG, Magnusson PU, Dejana E.
    Endothelial cell clonal expansion in the development of cerebral cavernous malformations
    Nat Commun. 2019 Jun 24;10(1):2761. doi: 10.1038/s41467-019-10707-x. PMID: 31235698; PMCID: PMC6591323.

  6. Corada M, Orsenigo F, Bhat GP, Conze LL, Breviario F, Cunha SI, Claesson- Welsh L, Beznoussenko GV, Mironov AA, Bacigaluppi M, Martino G, Pitulescu ME, Adams RH, Magnusson P, Dejana E.
    Fine-Tuning of Sox17 and Canonical Wnt Coordinates the Permeability Properties of the Blood-Brain Barrier.
    Circ Res. 2019 Feb 15;124(4):511-525. doi: 10.1161/CIRCRESAHA.118.313316. PMID: 30591003; PMCID: PMC6407809.

  7. Morini MF, Giampietro C, Corada M, Pisati F, Lavarone E, Cunha SI, Conze LL, O'Reilly N, Joshi D, Kjaer S, George R, Nye E, Ma A, Jin J, Mitter R, Lupia M, Cavallaro U, Pasini D, Calado DP, Dejana E, Taddei A.
    VE-Cadherin-Mediated Epigenetic Regulation of Endothelial Gene Expression.
    Circ Res. 2018 Jan 19;122(2):231-245. doi: 10.1161/CIRCRESAHA.117.312392. Epub 2017 Dec 12. PMID: 29233846; PMCID: PMC5771688.

  8. Hirschi KK, Dejana E.
    Resident Endothelial Progenitors Make Themselves at Home
    Cell Stem Cell. 2018 Aug 2;23(2):153-155. doi: 10.1016/j.stem.2018.07.014. PMID: 30075124.

  9. Dejana E, Lampugnani MG.
    Endothelial cell transitions.
    Science. 2018 Nov 16;362(6416):746-747. doi: 10.1126/science.aas9432. PMID: 30442789.

  10. Cunha SI, Magnusson PU, Dejana E, Lampugnani MG.
    Deregulated TGF-β/BMP Signaling in Vascular Malformations.
    Circ Res. 2017 Sep 29;121(8):981-999. doi: 10.1161/CIRCRESAHA.117.309930. Review. PMID:28963191

  11. Erba BG, Gruppi C, Corada M, Pisati F, Rosti V, Bartalucci N, Villeval JL, Vannucchi AM, Barosi G, Balduini A, Dejana E.
    Endothelial-to-Mesenchymal Transition in Bone Marrow and Spleen of Primary Myelofibrosis.
    Am J Pathol. 2017 Aug;187(8):1879-1892. doi: 10.1016/j.ajpath.2017.04.006. PMID: 28728747

  12. Dejana E, Hirschi KK, Simons M.
    The molecular basis of endothelial cell plasticity.
    Nat Commun. 2017 Feb 9;8:14361. doi: 10.1038/ncomms14361. Review. PMID:28181491

  13. Lampugnani MG, Dejana E, Giampietro C.
    Vascular Endothelial (VE)-Cadherin, Endothelial Adherens Junctions, and Vascular Disease.
    Cold Spring Harb Perspect Biol. 2017 Sep 28. pii: a029322. doi: 10.1101/cshperspect.a029322.

  14. Chiang IK, Fritzsche M, Pichol-Thievend C, Neal A, Holmes K, Lagendijk A, Overman J, D'Angelo D, Omini A, Hermkens D, Lesieur E, Liu K, Ratnayaka I, Corada M, Bou-Gharios G, Carroll J, Dejana E, Schulte-Merker S, Hogan B, Beltrame M, De Val S, Francois M.
    SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development.
    Development. 2017 Jul 15;144(14):2629-2639. doi: 10.1242/dev.146241. Epub 2017 Jun 15

  15. Conway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA.
    VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN.
    Curr Biol. 2017 Jul 24;27(14):2219-2225.e5. doi: 10.1016/j.cub.2017.06.020. Epub 2017 Jul 14

  16. Malinverno M, Corada M, Ferrarini L, Formicola L, Marazzi G, Sassoon D, Dejana E.
    Peg3/PW1 Is a Marker of a Subset of Vessel Associated Endothelial Progenitors.
    Stem Cells. 2017 May;35(5):1328-1340. doi: 10.1002/stem.2566. Epub 2017 Feb 5.

  17. Lampugnani MG, Malinverno M, Dejana E, Rudini N.
    Endothelial cell disease: emerging knowledge from cerebral cavernous malformations.
    Curr Opin Hematol. 2017 May;24(3):256-264. doi: 10.1097/MOH.0000000000000338. Review. PMID: 28212190

  18. Chen Q, Zhang H, Liu Y, Adams S, Eilken H, Stehling M, Corada M, Dejana E, Zhou B, Adams RH.
    Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells.
    Nat Commun. 2016 Aug 12;7:12422. doi: 10.1038/ncomms12422.

  19. Gordon EJ, Fukuhara D, Weström S, Padhan N, Sjöström EO, van Meeteren L, He L, Orsenigo F, Dejana E, Bentley K, Spurkland A, Claesson-Welsh L.
    The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation.
    Sci Signal. 2016 Jul 19;9(437):ra72. doi: 10.1126/scisignal.aad9256

  20. Li X, Padhan N, Sjöström EO, Roche FP, Testini C, Honkura N, Sáinz-Jaspeado M, Gordon E, Bentley K, Philippides A, Tolmachev V, Dejana E, Stan RV, Vestweber D, Ballmer-Hofer K, Betsholtz C, Pietras K, Jansson L, Claesson-Welsh L.
    VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread.
    Nat Commun. 2016 Mar 23;7:11017. doi: 10.1038/ncomms11017

  21. Bravi L, Malinverno M, Pisati F, Rudini N, Cuttano R, Pallini R, Martini M, Larocca LM, Locatelli M, Levi V, Bertani GA, Dejana E, Lampugnani MG.
    Endothelial Cells Lining Sporadic Cerebral Cavernous Malformation Cavernomas Undergo Endothelial-to-Mesenchymal Transition.
    Stroke. 2016 Feb 2. pii: STROKEAHA.115.011867. [Epub ahead of print] PubMed PMID: 26839352.

  22. Dejana E, Betsholtz C.
    NEURODEVELOPMENT. Oligodendrocytes follow blood vessel trails in the brain.
    Science. 2016 Jan 22;351(6271):341-2. doi:10.1126/science.aaf1139. PubMed PMID: 26798001.

  23. Giampietro C, Disanza A, Bravi L, Barrios-Rodiles M, Corada M, Frittoli E, Savorani C, Lampugnani MG, Boggetti B, Niessen C, Wrana JL, Scita G, Dejana E.
    The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling.
    J Cell Biol. 2015 Dec 21;211(6):1177-92. doi:10.1083/jcb.201501089. Epub 2015 Dec 14. PubMed PMID: 26668327.

  24. Cuttano R, Rudini N, Bravi L, Corada M, Giampietro C, Papa E, Morini MF, Maddaluno L, Baeyens N, Adams RH, Jain MK, Owens GK, Schwartz M, Lampugnani MG, Dejana E.
    KLF4 is a key determinant in the development and progression of cerebral cavernous malformations.
    EMBO Mol Med. 2015 Nov 26;8(1):6-24. doi: 10.15252/emmm.201505433. PubMed PMID: 26612856; PubMed Central PMCID: PMC4718159.

  25. Spadoni I, Zagato E, Bertocchi A, Paolinelli R, Hot E, Di Sabatino A, Caprioli F, Bottiglieri L, Oldani A, Viale G, Penna G, Dejana E, Rescigno M.
    A gut-vascular barrier controls the systemic dissemination of bacteria.
    Science. 2015 Nov 13;350(6262):830-4. doi: 10.1126/science.aad0135. PubMed PMID: 26564856.

  26. Giampietro C, Deflorian G, Gallo S, Di Matteo A, Pradella D, Bonomi S, Belloni E, Nyqvist D, Quaranta V, Confalonieri S, Bertalot G, Orsenigo F, Pisati F, Ferrero E, Biamonti G, Fredrickx E, Taveggia C, Wyatt CD, Irimia M, Di Fiore PP, Blencowe BJ, Dejana E, Ghigna C.
    The alternative splicing factor Nova2 regulates vascular development and lumen formation.
    Nat Commun. 2015 Oct 8;6:8479. doi: 10.1038/ncomms9479. PubMed PMID: 26446569; PubMed Central PMCID: PMC4633719.

  27. Marchi S, Corricelli M, Trapani E, Bravi L, Pittaro A, Delle Monache S, Ferroni L, Patergnani S, Missiroli S, Goitre L, Trabalzini L, Rimessi A, Giorgi C, Zavan B, Cassoni P, Dejana E, Retta SF, Pinton P.
    Defective autophagy is a key feature of cerebral cavernous malformations.
    EMBO Mol Med. 2015 Sep 28;7(11):1403-17. doi: 10.15252/emmm.201505316. PubMed PMID: 26417067; PubMed Central PMCID: PMC4644374.

  28. Nailor A, Dejana E, Reynolds AR, Punwani S, Curigliano G, Bertolini F, Shah M, Danesi R, Kerbel R, McVie G.
    DLessons from the first ecancer symposium on angiogenesis in gastric cancer.
    Ecancermedicalscience. 2015 Jul 21;9:553. doi: 10.3332/ecancer.2015.553. eCollection 2015. PubMed PMID: 26284117; PubMed Central PMCID: PMC4531128.

  29. Bravi L, Rudini N, Cuttano R, Giampietro C, Maddaluno L, Ferrarini L, Adams RH, Corada M, Boulday G, Tournier-Lasserve E, Dejana E, Lampugnani MG.
    Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice.
    Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8421-6. doi: 10.1073/pnas.1501352112. Epub 2015 Jun 24. PubMed PMID: 26109568; PubMed Central PMCID: PMC4500248.

  30. Trani M, Dejana E.
    New insights in the control of vascular permeability: vascular endothelial-cadherin and other players.
    Curr Opin Hematol. 2015 May;22(3):267-72. doi: 10.1097/MOH.0000000000000137. Review. PubMed PMID: 25767951.

  31. Tacconi C, Correale C, Gandelli A, Spinelli A, Dejana E, D'Alessio S, Danese S.
    Vascular endothelial growth factor C disrupts the endothelial lymphatic barrier to promote colorectal cancer invasion.
    Gastroenterology. 2015 Jun;148(7):1438-51.e8. doi: 10.1053/j.gastro.2015.03.005. Epub 2015 Mar 6. PubMed PMID: 25754161.

  32. Bonfanti C, Rossi G, Tedesco FS, Giannotta M, Benedetti S, Tonlorenzi R, Antonini S, Marazzi G, Dejana E, Sassoon D, Cossu G, Messina G.
    PW1/Peg3 expression regulates key properties that determine mesoangioblast stem cell competence.
    Nat Commun. 2015 Mar 9;6:6364. doi: 10.1038/ncomms7364. PubMed PMID: 25751651; PubMed Central PMCID: PMC4366533.

  33. Birdsey GM, Shah AV, Dufton N, Reynolds LE, Osuna Almagro L, Yang Y, Aspalter IM, Khan ST, Mason JC, Dejana E, Göttgens B, Hodivala-Dilke K, Gerhardt H, Adams RH, Randi AM.
    The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling.
    Dev Cell. 2015 Jan 12;32(1):82-96. doi: 10.1016/j.devcel.2014.11.016. PubMed PMID: 25584796; PubMed Central PMCID: PMC4292982.

  34. Corada M, Morini MF, Dejana E.
    Signaling pathways in the specification of arteries and veins.
    Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2372-7. doi: 10.1161/ATVBAHA.114.303218. Epub 2014 Aug 28. Review. PubMed PMID: 25169934.

  35. Magrini E, Villa A, Angiolini F, Doni A, Mazzarol G, Rudini N, Maddaluno L, Komuta M, Topal B, Prenen H, Schachner M, Confalonieri S, Dejana E, Bianchi F, Mazzone M, Cavallaro U.
    Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization.
    J Clin Invest. 2014 Oct;124(10):4335-50. doi: 10.1172/JCI70683. Epub 2014 Aug 26. PubMed PMID: 25157817; PubMed Central PMCID: PMC4191010.

  36. Maes H, Kuchnio A, Peric A, Moens S, Nys K, De Bock K, Quaegebeur A, Schoors S, Georgiadou M, Wouters J, Vinckier S, Vankelecom H, Garmyn M, Vion AC, Radtke F, Boulanger C, Gerhardt H, Dejana E, Dewerchin M, Ghesquière B, Annaert W, Agostinis P, Carmeliet P.
    Tumor vessel normalization by chloroquine independent of autophagy.
    Cancer Cell. 2014 Aug 11;26(2):190-206. doi: 10.1016/j.ccr.2014.06.025. PubMed PMID: 25117709.

  37. Zheng W, Nurmi H, Appak S, Sabine A, Bovay E, Korhonen EA, Orsenigo F, Lohela M, D'Amico G, Holopainen T, Leow CC, Dejana E, Petrova TV, Augustin HG, Alitalo K.
    Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions.
    Genes Dev. 2014 Jul 15;28(14):1592-603. doi: 10.1101/gad.237677.114. PubMed PMID: 25030698; PubMed Central PMCID: PMC4102766.

  38. Moreno V, Gonzalo P, Gómez-Escudero J, Pollán Á, Acín-Pérez R, Breckenridge M, Yáñez-Mó M, Barreiro O, Orsenigo F, Kadomatsu K, Chen CS, Enríquez JA, Dejana E, Sánchez-Madrid F, Arroyo AG.
    An EMMPRIN-γ-catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions.
    J Cell Sci. 2014 Sep 1;127(Pt 17):3768-81. doi: 10.1242/jcs.149518. Epub 2014 Jul 2. PubMed PMID: 24994937; PubMed Central PMCID: PMC4150062.

  39. Dejana E, Lampugnani MG.
    Differential adhesion drives angiogenesis.
    Nat Cell Biol. 2014 Apr;16(4):305-6. doi: 10.1038/ncb2943. PubMed PMID: 24691258.

  40. Bravi L, Dejana E, Lampugnani MG.
    VE-cadherin at a glance.
    Cell Tissue Res. 2014 Mar;355(3):515-22. doi: 10.1007/s00441-014-1843-7. Epub 2014 Mar 20. PubMed PMID: 24643676.

  41. Morini MF, Dejana E
    Transcriptional regulation of arterial differentiation via Wnt, Sox and Notch.
    Curr Opin Hematol. 2014 May;21(3):229-34. doi: 10.1097/MOH.0000000000000043. Review. PubMed PMID: 24626043.

  42. Goddard LM, Murphy TJ, Org T, Enciso JM, Hashimoto-Partyka MK, Warren CM, Domigan CK, McDonald AI, He H, Sanchez LA, Allen NC, Orsenigo F, Chao LC, Dejana E, Tontonoz P, Mikkola HK, Iruela-Arispe ML.
    Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation.
    Cell. 2014 Jan 30;156(3):549-62. doi: 10.1016/j.cell.2013.12.025. PubMed PMID: 24485460; PubMed Central PMCID: PMC3985399.

  43. Jean C, Chen XL, Nam JO, Tancioni I, Uryu S, Lawson C, Ward KK, Walsh CT, Miller NL, Ghassemian M, Turowski P, Dejana E, Weis S, Cheresh DA, Schlaepfer DD.
    Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function.
    J Cell Biol. 2014 Jan 20;204(2):247-63. doi: 10.1083/jcb.201307067. PubMed PMID: 24446483; PubMed Central PMCID: PMC3897185.

  44. Giannotta M, Benedetti S, Tedesco FS, Corada M, Trani M, D'Antuono R, Millet Q, Orsenigo F, Gálvez BG, Cossu G, Dejana E.
    Targeting endothelial junctional adhesion molecule-A/ EPAC/ Rap-1 axis as a novel strategy to increase stem cell engraftment in dystrophic muscles.
    EMBO Mol Med. 2014 Feb;6(2):239-58. doi: 10.1002/emmm.201302520. Epub 2013 Dec 30. PubMed PMID: 24378569; PubMed Central PMCID: PMC3927958.

  45. Corada M, Orsenigo F, Morini MF, Pitulescu ME, Bhat G, Nyqvist D, Breviario F, Conti V, Briot A, Iruela-Arispe ML, Adams RH, Dejana E.
    Sox17 is indispensable for acquisition and maintenance of arterial identity.
    Nat Commun. 2013;4:2609. doi: 10.1038/ncomms3609. PubMed PMID: 24153254; PubMed Central PMCID: PMC3826640.

  46. Giannotta M, Trani M, Dejana E.
    VE-cadherin and endothelial adherens junctions: active guardians of vascular integrity.
    Dev Cell. 2013 Sep 16;26(5):441-54. doi: 10.1016/j.devcel.2013.08.020. Review. PubMed PMID: 24044891.

  47. Paolinelli R, Corada M, Ferrarini L, Devraj K, Artus C, Czupalla CJ, Rudini N, Maddaluno L, Papa E, Engelhardt B, Couraud PO, Liebner S, Dejana E.
    Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro.
    PLoS One. 2013 Aug 5;8(8):e70233. doi: 10.1371/journal.pone.0070233. Print 2013. PubMed PMID: 23940549; PubMed Central PMCID: PMC3734070.

  48. Dejana E, Orsenigo F.
    Endothelial adherens junctions at a glance.
    J Cell Sci. 2013 Jun 15;126(Pt 12):2545-9. doi: 10.1242/jcs.124529. Epub 2013 Jun 18. Review. PubMed PMID: 23781019.

  49. Hayashi M, Majumdar A, Li X, Adler J, Sun Z, Vertuani S, Hellberg C, Mellberg S, Koch S, Dimberg A, Koh GY, Dejana E, Belting HG, Affolter M, Thurston G, Holmgren L, Vestweber D, Claesson-Welsh L.
    VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation.
    Nat Commun. 2013;4:1672. doi: 10.1038/ncomms2683. PubMed PMID: 23575676; PubMed Central PMCID: PMC3644080.

  50. Maddaluno L, Rudini N, Cuttano R, Bravi L, Costanza Giampietro, Corada M, Ferrarini L, Orsenigo F, Papa E, Boulday G, Tournier-Lasserve E, Chapon F, Richichi C, Retta SF, Lampugnani MG, Dejana E.
    EndMT contributes to the onset and progression of cerebral cavernous malformations.
    Nature. 2013 Jun 9. doi: 10.1038/nature12207. PMID: 23748444

  51. Dejana E, Vestweber D
    The Role of VE-Cadherin in Vascular Morphogenesis and Permeability Control.
    Prog Mol Biol Transl Sci. 2013;116:119-44. PubMed PMID: 23481193.

  52. Dejana E, Giampietro C.
    Vascular endothelial-cadherin and vascular stability.
    Curr Opin Hematol. 2012 May;19(3):218-23. Review. PubMed PMID: 22395663.

  53. Giampietro C, Taddei A, Corada M, Sarra-Ferraris GM, Alcalay M, Cavallaro U, Orsenigo F, Lampugnani MG, Dejana E.
    Overlapping and divergent signaling pathways of N-cadherin and VE-cadherin in endothelial cells.
    Blood. 2012 Mar 1;119(9):2159-70. Epub 2012 Jan 12. PubMed PMID: 22246030.

  54. Orsenigo F, Giampietro C, Ferrari A, Corada M, Galaup A, Sigismund S, Ristagno G, Maddaluno L, Koh GY, Franco D, Kurtcuoglu V, Poulikakos D, Baluk P, McDonald D, Grazia Lampugnani M, Dejana E.
    Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo.
    Nat Commun. 2012;3:1208. PubMed PMID: 23169049; PubMed Central PMCID: PMC3514492.

  55. Boulday G, Rudini N, Maddaluno L, Blécon A, Arnould M, Gaudric A, Chapon F, Adams RH, Dejana E, Tournier-Lasserve E.
    Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice.
    J Exp Med. 2011 Aug 29;208(9):1835-47. Epub 2011 Aug 22. PubMed PMID: 21859843; PubMed Central PMCID: PMC3171098.

  56. Cavallaro U, Dejana E.
    Adhesion molecule signalling: not always a sticky business.
    Nat Rev Mol Cell Biol. 2011 Mar;12(3):189-97. Review. PubMed PMID: 21346732.

  57. Paolinelli R, Corada M, Orsenigo F, Dejana E.
    The molecular basis of the blood brain barrier differentiation and maintenance. Is it still a mystery?
    Pharmacol Res. 2011 Mar;63(3):165-71. Epub 2010 Dec 15. Review. PubMed PMID: 21167284.

  58. Murakami M, Giampietro C, Giannotta M, Corada M, Torselli I, Orsenigo F, Cocito A, d'Ario G, Mazzarol G, Confalonieri S, Di Fiore PP, Dejana E.
    Abrogation of junctional adhesion molecule-A expression induces cell apoptosis and reduces breast cancer progression
    PLoS One. 2011;6(6):e21242. Epub 2011 Jun 17. PubMed PMID: 21695058; PubMed Central PMCID: PMC3117883.

  59. Dejana E, Nyqvist D.
    News from the brain: the GPR124 orphan receptor directs brain-specific angiogenesis.
    Sci Transl Med. 2010 Nov 17;2(58):58ps53. PubMed PMID: 21084718.

  60. Hermans K, Claes F, Vandevelde W, Zheng W, Geudens I, Orsenigo F, De Smet F, Gjini E, Anthonis K, Ren B, Kerjaschki D, Autiero M, Ny A, Simons M, Dewerchin M, Schulte-Merker S, Dejana E, Alitalo K, Carmeliet P.
    Role of synectin in lymphatic development in zebrafish and frogs.
    Blood. 2010 Oct 28;116(17):3356-66. Epub 2010 Jul 14. PubMed PMID: 20631376; PubMed Central PMCID: PMC3490102.

  61. Dejana E.
    The role of wnt signaling in physiological and pathological angiogenesis.
    Circ Res. 2010 Oct 15;107(8):943-52. Review. PubMed PMID: 20947863.

  62. Corada M, Nyqvist D, Orsenigo F, Caprini A, Giampietro C, Taketo MM, Iruela-Arispe ML, Adams RH, Dejana E.
    The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling.
    Dev Cell. 2010 Jun 15;18(6):938-49. PubMed PMID: 20627076.

  63. Lampugnani MG, Orsenigo F, Rudini N, Maddaluno L, Boulday G, Chapon F, Dejana E.
    CCM1 regulates vascular-lumen organization by inducing endothelial polarity.
    J Cell Sci. 2010 Apr 1;123(Pt 7):1073-80. PubMed PMID: 20332120.

  64. Murakami M, Francavilla C, Torselli I, Corada M, Maddaluno L, Sica A, Matteoli G, Iliev ID, Mantovani A, Rescigno M, Cavallaro U, Dejana E.
    Inactivation of junctional adhesion molecule-A enhances antitumoral immune response by promoting dendritic cell and T lymphocyte infiltration.
    Cancer Res. 2010 Mar 1;70(5):1759-65. Epub 2010 Feb 16. PubMed PMID: 20160037.

  65. Abraham S, Yeo M, Montero-Balaguer M, Paterson H, Dejana E, Marshall CJ, Mavria G.
    VE-Cadherin-Mediated Cell-Cell Interaction Suppresses Sprouting via Signaling to MLC2 Phosphorylation.
    Curr Biol. 2009 Apr 1. [Epub ahead of print] PubMed PMID: 19345098.

  66. Dejana E, Tournier-Lasserve E, Weinstein BM.
    The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications.
    Dev Cell. 2009 Feb;16(2):209-21. Review. PubMed PMID: 19217423.

  67. Mazzone M, Dettori D, Leite de Oliveira R, Loges S, Schmidt T, Jonckx B, Tian YM, Lanahan AA, Pollard P, Ruiz de Almodovar C, De Smet F, Vinckier S, Aragonés J, Debackere K, Luttun A, Wyns S, Jordan B, Pisacane A, Gallez B, Lampugnani MG, Dejana E, Simons M, Ratcliffe P, Maxwell P, Carmeliet P.
    Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.
    Cell. 2009 Mar 6;136(5):839-51. Epub 2009 Feb 12. PubMed PMID: 19217150.

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