IFOM Dana Branzei Lab

Dana Branzei Lab

Dana Branzei

Rumena, biologa molecolare, Dana Branzei dirige presso IFOM il Laboratorio dedicato allo studio dei meccanismi di riparazione del DNA.
Già giovanissima, grazie anche al suo mentore - un medico farmacologo che la accompagna nei primi anni del percorso di formazione - scopre la sua vocazione per la chimica. scopri di più

Contatta il ricercatore

Meccanismi di riparazione del DNA

Ricostruire il processo di riparazione del genoma nel corso della duplicazione delle cellule e, quindi, capire in che modo "si aggiusta" dalle lesioni che si possono verificare durante il processo di copiatura dei filamenti di DNA presenti nel nucleo: questo l'obiettivo del programma di ricerca condotto da Dana Branzei. scopri di più

Sede Laboratorio: Milano, Italia

Pubblicazioni Recenti

  • Ryotaro Kawasumi, Takuya Abe, Ivan Psakhye, Keiji Miyata, Kouji Hirota, and Dana Branzei* (2021).
    Vertebrate CTF18 and DDX11 essential function in cohesion is bypassed by preventing WAPL-mediated cohesin release.
    Genes Dev, doi: 10.1101/gad.348581.121.
  • Ivan Psakhye and Dana Branzei*(2021).
    SMC complexes are guarded by the SUMO protease Ulp2 against SUMO-chain-mediated turnover.
    Cell Reports 36(5):109485.
  • Dana Branzei* and Barnabas Szakal (2021).
    DNA helicases in homologous recombination repair.
    Curr Opin Genet Dev 71:27-33.
  • Nanda Kumar Jegadesan and Dana Branzei*.
    DDX11 loss causes replication stress and pharmacologically exploitable DNA repair defects.
    Proc Natl Acad Sci 118: e2024258118, doi:10.1073/pnas.2024258118.
  • Sumedha Agashe, Chinnu Rose Joseph, Teresa Anne Clarisse Reyes, Demis Menolfi, Michele Giannattasio, Anja Waizenegger, Barnabas Szakal and Dana Branzei* (2021).
    Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites.
    Nat Commun 12(1):2111, doi.org/10.1038/s41467-021-22217-w.
  • Anja Waizenegger, Madhusoodanan Urulangodi, Carl P. Lehmann, Teresa Anne Clarisse Reyes, Irene Saugar, Jose Antonio Tercero, Barnabas Szakal, and Dana Branzei* (2020).
    Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity.
    Nat Commun 11:5746 https://doi.org/10.1038/s41467-020-19503-4.
  • Francesco Rossi, Anne Helbling-Leclerc, Ryotaro Kawasumi, Nanda Kumar Jegadesan, Xinlin Xu, Pierre Devulder, Takuya Abe, Minoru Takata, Dongyi Xu, Filippo Rosselli, and Dana Branzei* (2020).
    SMC5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability.
    EMBO Reports 21(2): e48222. doi: 10.15252/embr.201948222
  • Ivan Psakhye, Federica Castellucci, Dana Branzei* (2019).
    SUMO-Chain-Regulated Proteasomal Degradation Timing Exemplified in DNA Replication Initiation.
    Mol Cell pii: S1097-2765(19)30619-7. doi: 10.1016/j.molcel.2019.08.003.
  • Takuya Abe, Ryotaro Kawasumi, Michele Giannattasio, Sabrina Dusi, Yui Yoshimoto, Keiji Miyata, Koyuki Umemura, Kouji Hirota, and Dana Branzei* (2018).
    AND-1 fork protection function prevents fork resection and is essential for proliferation.
    Nat Commun 9: 3091. doi: 10.1038/s41467-018-05586-7.
  • Takuya Abe, Masato Ooka, Ryotaro Kawasumi, Keiji Miyata, Minoru Takata, Kouji Hirota, and Dana Branzei* (2018).
    Warsaw Breakage Syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites.
    Proc Natl Acad Sci pii: 201803110. doi: 10.1073/pnas.1803110115.
  • Ryotaro Kawasumi, Takuya Abe*, Hiroshi Arakawa, Massimiliano Garre, Kouji Hirota, and Dana Branzei* (2017).
    ESCO1/2 roles in chromosome structure and interphase chromatin organization.
    Genes Dev, doi: 10.1101/gad.306084.117.
  • * indicates the corresponding author

Membri del gruppo

Staff Scientist
Szakal Barnabas
Technician
Dusi Sabrina
Post doc
Joseph Chinnu Rose
Mastrodonato Valeria
Nunomiya Aki
Psakhye Ivan
Phd Student
Bene Szabolcs
Dolce Valeria
Jegadesan Nanda Kumar
Morea Alessandro
Reyes Clarisse Teresa Anne
Undergraduate Student
Jafarzadeh Shaghayegh
Former Lab members
Ryotaro Kawasumi (postdoc)
Matteo Villa (postdoc)
Demis Menolfi (Master student, PhD student, postdoc)
Marco Fumasoni (Master student, PhD student, postdoc)
Federica Castellucci (PhD student, postdoc)
Saho Era (PhD student)
Takuya Abe (postdoc)
Madhusoodanan Urulangodi (postdoc)
Victor Gonzalez-Huici (postdoc)
Marek Sebesta (postdoc)
Fabio Vanoli (postdoc)
Julie Sollier (postdoc)
Eerappa Rajakumara (postdoc)
Livia Provitera (postdoc)
Teresa Anne Clarisse Reyes (Master student)
Beatrice Toia (Master student)
Alexandra Mayer (postdoc)
Francesco Rossi (PhD student, postdoc)

(update: Oct 2021)

IFOM Review

Seeing is believing: catching template-switching in the act
Commentary on Dana Branzei's paper published on Nature Structural & Molecular Biology, by Michael Lichten (2015)
complete review

Rassegna Stampa

Quelli che decidono di restare in Italia
2016.02.17

Il Corriere della Sera | G.Caprara, A. De Gregorio, V. Santarpia

Unravelling the secrets of DNA repair
euresearcher.com

2013.01.01 

DNA lifting
Marie Claire

2010.03.01 | Enrica Caretta

Rassegna Stampa del ricercatore