IFOM Pubblicazioni Fabrizio d'Adda di Fagagna

Pubblicazioni Fabrizio d'Adda di Fagagna

  1. Anna K. Uryga, Mandy O. J. Grootaert, Abel M. Garrido, Sebnem Oc, Kirsty Foote, Joel Chappell, Alison Finigan, Francesca Rossiello, Fabrizio d?Adda di Fagagna, Dimitra Aravani, Helle F. Jorgensen & Martin R. Bennett
    Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury
    Communications Biology volume 4, Article number: 611 (2021)

  2. Matteo Cabrini, Marco Roncador, Alessandro Galbiati, Lina Cipolla, Antonio Maffia, Fabio Iannelli, Simone Sabbioneda, Fabrizio d'Adda di Fagagna, Sofia Francia
    DROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end joining
    J Cell Sci. 2021 Mar 22;134(6):jcs249706. doi: 10.1242/jcs.249706.

  3. Elisa Mentegari, Federica Bertoletti, Miroslava Kissova, Elisa Zucca, Silvia Galli, Giulia Tagliavini, Anna Garbelli, Antonio Maffia, Silvia Bione, Elena Ferrari, Fabrizio d'Adda di Fagagna, Sofia Francia, Simone Sabbioneda, Liuh-Yow Chen, Joachim Lingner, Valerie Bergoglio, Jean-Sébastien Hoffmann, Ulrich Hübscher, Emmanuele Crespan, and Giovanni Maga
    A Role for Human DNA Polymerase λ in Alternative Lengthening of Telomeres
    Int. J. Mol. Sci. 2021, 22(5), 2365

  4. Sheetal Sharma, Roopesh Anand, Xuzhu Zhang, Sofia Francia, Flavia Michelini, Alessandro Galbiati, Hannah Williams, Daryl A Ronato, Jean-Yves Masson, Eli Rothenberg, Petr Cejka, Fabrizio d'Adda di Fagagna
    MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends
    Cell Rep. 2021 Jan 5;34(1):108565. doi: 10.1016/j.celrep.2020.108565.

  5. Ilaria Rosso, Fabrizio d'Adda di Fagagna
    Detection of Telomeric DNA:RNA Hybrids Using TeloDRIP-qPCR
    Int J Mol Sci. 2020 Dec 21;21(24):9774. doi: 10.3390/ijms21249774.

  6. Raffaella Di Micco, Valery Krizhanovsky, Darren Baker & Fabrizio d'Adda di Fagagna
    Cellular senescence in ageing: from mechanisms to therapeutic opportunities
    Nature Reviews Molecular Cell Biology (2020)

  7. Fabio Pessina, Ubaldo Gioia, Ornella Brandi, Stefania Farina, Marta Ceccon, Sofia Francia, Fabrizio d'Adda di Fagagna
    DNA Damage Triggers a New Phase in Neurodegeneration
    Trends Genet. 2020 Oct 2;S0168-9525(20)30242-0. doi: 10.1016/j.tig.2020.09.006. Online ahead of print.

  8. Julio Aguado, Fabrizio d'Adda di Fagagna, Ernst Wolvetang
    Telomere transcription in ageing
    Ageing Res Rev. 2020 Jun 18;62:101115. doi: 10.1016/j.arr.2020.101115. Online ahead of print.

  9. Julio Aguado, Agustin Sola-Carvajal, Valeria Cancila, Gwladys Revêchon, Peh Fern Ong, Corey Winston Jones-Weinert, Emelie Wallén Arzt, Giovanna Lattanzi, Oliver Dreesen, Claudio Tripodo, Francesca Rossiello, Maria Eriksson & Fabrizio d'Adda di Fagagna
    Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome
    Nature Communications volume 10, Article number: 4990 (2019)

  10. Fabio Pessina, Fabio Giavazzi, Yandong Yin, Ubaldo Gioia, Valerio Vitelli, Alessandro Galbiati, Sara Barozzi, Massimiliano Garrè, Amanda Oldani, Andrew Flaus, Roberto Cerbino, Dario Parazzoli, Eli Rothenberg and Fabrizio d'Adda di Fagagna
    Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors
    Nature Cell Biology volume 21, pages1286–1299 (2019)

  11. Ubaldo Gioia, Sofia Francia, Matteo Cabrini, Silvia Brambillasca, Flavia Michelini, Corey W. Jones-Weinert and Fabrizio d'Adda di Fagagna
    Pharmacological boost of DNA damage response and repair by enhanced biogenesis of DNA damage response RNAs.
    Scientific Reports 9, Article number: 6460 (2019)

  12. Flavia Michelini, Francesca Rossiello, Fabrizio d'Adda di Fagagna and Sofia Francia
    RNase A treatment and reconstitution with DNA damage response RNA in living cells as a tool to study the role of non-coding RNA in the formation of DNA damage response foci
    Nature Protocols (2019) - Published: 08 April 2019

  13. D'Alessandro G, Whelan DR, Howard SM, Vitelli V, Renaudin X, Adamowicz M, Iannelli F, Jones-Weinert CW, Lee M, Matti V, Lee WTC, Morten MJ, Venkitaraman AR, Cejka P, Rothenberg E, d'Adda di Fagagna.
    BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment.
    Nat Commun. 2018 Dec 18;9(1):5376. doi: 10.1038/s41467-018-07799-2.

  14. Alessandro Galbiati, Fabrizio d'Adda di Fagagna
    DNA Damage In Situ Ligation Followed by Proximity Ligation Assay (DI-PLA)
    Cellular Senescence (pp 11-20) 2018 Nov 25.

  15. Michelini F, Jalihal AP, Francia S, Meers C, Neeb ZT, Rossiello F, Gioia U, Aguado J, Jones-Weinert C, Luke B, Biamonti G, Nowacki M, Storici F, Carninci P, Walter NG, d'Adda di Fagagna F.
    From Cellular RNA to Smart RNA: Multiple Roles of RNA in Genome Stability and Beyond.
    Chem Rev. 2018 Apr 25;118(8):4365-4403. doi: 10.1021/acs.chemrev.7b00487. Epub 2018 Mar 30.

  16. Quan Nguyen, Julio Aguado, Fabio Iannelli, Ana Maria Suzuki, Francesca Rossiello, Fabrizio d'Adda di Fagagna and Piero Carninci
    Target-enrichment sequencing for detailed characterization of small RNAs
    Nature Protocols volume 13, pages 768–786 (2018) doi:10.1038/nprot.2018.001

  17. Adamowicz M, d'Adda di Fagagna F, Vermezovic J.
    NOTCH1 modulates activity of DNA-PKcs.
    Mutat Res. 2018 Feb 1;808:20-27. doi: 10.1016/j.mrfmmm.2018.01.003. [Epub ahead of print]

  18. Angela Palmigiano, Francesco Santaniello, Aurora Cerutti, Dmitry Penkov, Divya Purushothaman, Ekta Makhija, Lucilla Luzi, Fabrizio d’Adda di Fagagna, Pier Giuseppe Pelicci, Viveswara Shivashankar, Gaetano Ivan Dellino & Francesco Blasi
    PREP1 tumor suppressor protects the late-replicating DNA by controlling its replication timing and symmetry
    Scientific Reportsvolume 8, Article number: 3198 (2018) doi:10.1038/s41598-018-21363-4

  19. Michelini F, Pitchiaya S, Vitelli V, Sharma S, Gioia U, Pessina F, Cabrini M, Wang Y, Capozzo I, Iannelli F, Matti V, Francia S, Shivashankar GV, Walter NG, d'Adda di Fagagna F.
    Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks.
    Nat Cell Biol. 2017 Dec;19(12):1400-1411. doi: 10.1038/ncb3643. Epub 2017 Nov 27.

  20. Valerio Vitelli, Alessandro Galbiati, Fabio Iannelli, Fabio Pessina, Sheetal Sharma, and Fabrizio d'Adda di Fagagna
    Recent Advancements in DNA Damage-Transcription Crosstalk and High-Resolution Mapping of DNA Breaks.
    Annual Review of Genomics and Human Genetics Vol. 18:87-113 (August 2017) Citations: 9

  21. Ishwarya Venkata Narayanan, Michelle T. Paulsen, Karan Bedi, Nathan Berg, Emily A. Ljungman, Sofia Francia, Artur Veloso, Brian Magnuson, Fabrizio d'Adda di Fagagna, Thomas E. Wilson & Mats Ljungman
    Transcriptional and post-transcriptional regulation of the ionizing radiation response by ATM and p53
    Scientific Reports 7, Article number: 43598 (2017) doi:10.1038/srep43598

  22. Francesca Rossiello, Julio Aguado, Sara Sepe, Fabio Iannelli, Quan Nguyen, Sethuramasundaram Pitchiaya, Piero Carninci & Fabrizio d'Adda di Fagagna
    DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
    Nature Communications 8, Article number: 13980 (2017) doi:10.1038/ncomms13980

  23. Capozzo I, Iannelli F, Francia S, d'Adda di Fagagna F.
    Express or Repress? The Transcriptional Dilemma of Damaged Chromatin.
    FEBS J. 2017 Feb 23. doi: 10.1111/febs.14048. [Epub ahead of print]

  24. Alessandro Galbiati, Christian Beauséjour, Fabrizio d'Adda di Fagagna
    A novel single-cell method provides direct evidence of persistent DNA damage in senescent cells and aged mammalian tissues
    Aging Cell 2017 January DOI: 10.1111/acel.12573

  25. Giuseppina D'Alessandro, Fabrizio d'Adda di Fagagna
    Transcription and DNA Damage: Holding Hands or Crossing Swords?
    Journal of Molecular Biology 2016 Nov doi: /10.1016/j.jmb.2016.11.002 [Epub ahead of print]

  26. Marek Adamowicz, Jelena Vermezovic, Fabrizio d'Adda di Fagagna
    NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex
    Cell Rep. 2016 Aug 10. pii: S2211-1247(16)30956-1. doi: 10.1016/j.celrep.2016.07.038. [Epub ahead of print]

  27. Sofia Francia, Matteo Cabrini, Valentina Matti, Amanda Oldani, Fabrizio d'Adda di Fagagna
    DICER, DROSHA and DNA damage-response RNAs are necessary for the secondary recruitment of DNA damage response factors
    J Cell Sci 2016 : doi: 10.1242/jcs.182188

  28. Nicola Manfrini, Michela Clerici, Maxime Wery, Chiara Vittoria Colombo, Marc Descrimes, Antonin Morillon, Fabrizio d'Adda di Fagagna, Maria Pia Longhese
    Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae
    eLife 2015;10.7554/eLife.08942, July 31, 2015

  29. Gioia U, d'Adda di Fagagna F.
    Human nuclear ARGONAUTE 2 interacts in vivo only with small RNAs and not with DNA.
    Cell Cycle. 2015 May 13:0. [Epub ahead of print]

  30. Jelena Vermezovic, Marek Adamowicz, Libero Santarpia, Alessandra Rustighi, Mattia Forcato, Caterina Lucano, Lucia Massimiliano, Vincenzo Costanzo, Silvio Bicciato, Giannino Del Sal & Fabrizio d'Adda di Fagagna
    Notch is a direct negative regulator of the DNA-damage response
    Nature Structural & Molecular Biology (2015), doi:10.1038/nsmb.3013, Published online 20 April 2015

  31. Jitendra K Meena, Aurora Cerutti, Christine Beichler, Yohei Morita, Christopher Bruhn, Mukesh Kumar, Johann M Kraus, Michael R Speicher, Zhao–Qi Wang, Hans A Kestler, Fabrizio d'Adda di Fagagna, Cagatay Günes, Karl Lenhard Rudolph
    Telomerase abrogates aneuploidy–induced telomere replication stress, senescence and cell depletion
    The EMBO Journal (2015), DOI 10.15252/embj.201490070, Published online 27.03.2015

  32. Nicola Manfrini, Camilla Trovesi, Maxime Wery, Marina Martina, Daniele Cesena, Marc Descrimes, Antonin Morillon, Fabrizio d'Adda di Fagagna, Maria P Longhese
    RNA–processing proteins regulate Mec1/ATR activation by promoting generation of RPA–coated ssDNA
    EMBO Rep.; 2014 Dec 19. pii: e201439458. [Epub ahead of print]

  33. Marzia Fumagalli, Francesca Rossiello, Chiara Mondello, Fabrizio d'Adda di Fagagna
    Stable Cellular Senescence Is Associated with Persistent DDR Activation
    PLoS ONE; October 23, 2014; DOI: 10.1371/journal.pone.0110969.

  34. Rossiello F, Herbig U, Longhese MP, Fumagalli M, d'Adda di Fagagna F.
    Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing.
    Curr Opin Genet Dev. 2014 Aug 4;26C:89-95. doi: 10.1016/j.gde.2014.06.009.

  35. Piunti A, Rossi A, Cerutti A, Albert M, Jammula S, Scelfo A, Cedrone L, Fragola G, Olsson L, Koseki H, Testa G, Casola S, Helin K, d'Adda di Fagagna F, Pasini D.
    Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication.
    Nat Commun. 2014 Apr 14;5:3649. doi: 10.1038/ncomms4649.

  36. M Ogrunc, R Di Micco, M Liontos, L Bombardelli, M Mione, M Fumagalli, V G Gorgoulis and F d'Adda di Fagagna
    Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation
    Cell Death Differ advance online publication, February 28, 2014; doi:10.1038/cdd.2014.16

  37. Fabrizio d'Adda di Fagagna
    A direct role for small non-coding RNAs in DNA damage response
    Trends Cell Biol. 2013 Oct 21. pii: S0962-8924(13)00165-7. doi: 10.1016/j.tcb.2013.09.008.

  38. Leonid Schneider, Serena Pellegatta, Rebecca Favaro, Federica Pisati, Paola Roncaglia, Giuseppe Testa, Silvia K. Nicolis, Gaetano Finocchiaro, Fabrizio d'Adda di Fagagna
    DNA Damage in Mammalian Neural Stem Cells Leads to Astrocytic Differentiation Mediated by BMP2 Signaling through JAK-STAT
    Stem Cell Reports, 25 July 2013

  39. Gabriele Sulli, Raffaella Di Micco & Fabrizio d'Adda di Fagagna
    Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer
    Nature Reviews Cancer, advance online publication, Published online 6 September 2012 | doi:10.1038/nrc3344

  40. J Vermezovic, L Stergiou, M O Hengartner and F d'Adda di Fagagna
    Differential regulation of DNA damage response activation between somatic and germline cells in Caenorhabditis elegans
    Cell Death and Differentiation advance online publication 15 June 2012; doi: 10.1038/cdd.2012.69

  41. Sofia Francia, Flavia Michelini,  Alka Saxena,  Dave Tang, Michiel de Hoon, Viviana Anelli, Marina Mione, Piero Carninci & Fabrizio d'Adda di Fagagna
    Site-specific DICER and DROSHA RNA products control the DNA-damage response
    Nature (2012) doi:10.1038/nature11179

  42. Suram A, Kaplunov J, Patel PL, Ruan H, Cerutti A, Boccardi V, Fumagalli M, Di Micco R, Mirani N, Lal Gurung R, Prakash Hande M, d'Adda di Fagagna F, Herbig U.
    Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions.
    EMBO J. 2012 May 8. doi: 10.1038/emboj.2012.132. [Epub ahead of print]

  43. Fumagalli M, Rossiello F, Clerici M, Barozzi S, Cittaro D, Kaplunov JM, Bucci G, Dobreva M, Matti V, Beausejour CM, Herbig U, Longhese MP, d'Adda di Fagagna F.
    Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation.
    Nat Cell Biol. 2012 Mar 18;14(4):355-65. doi: 10.1038/ncb2466.

  44. Schneider L, d'Adda di Fagagna F.
    Neural stem cells exposed to BrdU lose their global DNA methylation and undergo astrocytic differentiation.
    Nucleic Acids Res. 2012 Feb 29. [Epub ahead of print]

  45. Giaimo S, d'Adda di Fagagna F.
    Is cellular senescence an example of antagonistic pleiotropy?
    Aging Cell. 2012 Feb 14. doi: 10.1111/j.1474-9726.2012.00807.x. [Epub ahead of print]

  46. L Schneider, M Fumagalli and F d'Adda di Fagagna
    Terminally differentiated astrocytes lack DNA damage response signaling and are radioresistant but retain DNA repair proficiency
    Cell Death and Differentiation advance online publication 7 October 2011; doi: 10.1038/cdd.2011.129

  47. Decottignies A. and d'Adda di Fagagna F.
    Epigenetic alterations associated with cellular senescence: a barrier against tumorigenesis or a red carpet for cancer?
    Semin Cancer Biol. 2011 Sep 16 PMID: 21946622 [PubMed - as supplied by publisher]

  48. Ogrunc M, d'Adda di Fagagna F.
    Never-ageing cellular senescence.
    Eur J Cancer. 2011 May 9 PMID: 21561762 [PubMed - as supplied by publisher]

  49. Di Micco R, Sulli G, Dobreva M, Liontos M, Botrugno OA, Gargiulo G, dal Zuffo R, Matti V, d'Ario G, Montani E, Mercurio C, Hahn WC, Gorgoulis V, Minucci S, d'Adda di Fagagna F.
    Interplay between oncogene-induced DNA Damage Response and heterochromatin in senescence and cancer.
    Nature Cell Biology 13, 292-302 (2011) PMID: 21336312 [PubMed - in process]

  50. Fumagalli M, d'Adda di Fagagna F.
    SASPense and DDRama in cancer and ageing.
    Nat Cell Biol. 2009 Aug;11(8):921-3. PMID: 19648977 [PubMed - in process]

  51. Evan GI, d'Adda di Fagagna F.
    Cellular senescence: hot or what?
    Curr Opin Genet Dev. 2009 Feb;19(1):25-31. Epub 2009 Jan 30. PMID: 19181515 [PubMed - in process]

  52. Santoriello C, Deflorian G, Pezzimenti F, Kawakami K, Lanfrancone L, d'Adda di Fagagna F, Mione M.
    Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells.
    Dis Model Mech. 2009 Jan-Feb;2(1-2):56-67. Epub 2008 Dec 22. PMID: 19132118 [PubMed - in process]

  53. Di Micco R., Cicalese A., Fumagalli M., Dobreva M., Verrecchia A., Pelicci P.G. and d'Adda di Fagagna F.
    DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization
    Cell Cycle 2008 Nov 7(22):3601-3606

  54. d'Adda di Fagagna F.
    Living on a break: cellular senescence as a DNA-damage response
    Nature Reviews Cancer 8, 512-522 (July 2008)

  55. Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d'Adda di Fagagna F, Bernard D, Hernando E, Gil J.
    Chemokine signaling via the CXCR2 receptor reinforces senescence.
    Cell. 2008 Jun 13;133(6):1006-18. PMID: 18555777 [PubMed - in process]

  56. d'Adda di Fagagna F.
    Cellular senescence and cellular longevity: Nearly 50 years on and still working on it.
    Exp Cell Res. 2008 Jun 10;314(9):1907-8. Epub 2008 Apr 8. No abstract available. PMID: 18474280 [PubMed - in process]

  57. Di Micco R, Fumagalli M, d'Adda di Fagagna F.
    Breaking news: high-speed race ends in arrest - how oncogenes induce senescence.
    Trends Cell Biol. 2007 Oct 31; [Epub ahead of print] PMID: 17980599 [PubMed - as supplied by publisher]

  58. Campisi J, d'Adda di Fagagna F.
    Cellular senescence: when bad things happen to good cells.
    Nat Rev Mol Cell Biol. 2007 Sep;8(9):729-40. PMID: 17667954 [PubMed - in process]

  59. Nucifororo PG, Luise C, Capra M, Pelosi G, d'Adda di Fagagna F.
    Complex engagement of DNA-damage response pathways in human cancer and in lung tumor progression.
    Carcinogenesis. 2007 May 22; [Epub ahead of print] PMID: 17522062 [PubMed - as supplied by publisher]

  60. Francia, S., Weiss, R.W., and d'Adda di Fagagna
    Need telomere maintenance? Call 911.
    F. Cell Division, 2007; PMID: 17229321

  61. Di Micco R., Fumagalli M., Cicalese A., Piccinin S. Gasparini P., Luise C., Schurra C., Garre' M., Nuciforo P., Bensimon A., Maestro R., Pelicci P.G., and d'Adda di Fagagna F.
    Oncogene-induced senescence is a DNA-damage checkpoint response triggered by DNA hyper-replication.
    Nature, 2006; 444: 638-642.

  62. Francia S., Weiss R.S., Hande M.P., Freire R., Jackson S.P. and d'Adda di Fagagna F.
    Telomere association, telomere length regulation and telomerase activity modulation by the mammalian Rad9/Rad1/Hus1 DNA damage checkpoint complex.
    Current Biology, 2006; 16: 1551-1558. 

  63. Giavara S., Kosmidou E., Hande M.P., Bianchi M.E., Morgan A., d'Adda di Fagagna F., and Jackson S.P.
    Involvement of HMGB proteins in the maintenance of genome stability.
    Current Biology, 2005; 15: 68-72.

  64. Von Zglinicki T., Saretzki G., Ladhoff J., d'Adda di Fagagna F., Jackson S.P.
    Human cell senescence as a DNA damage response.
    Mechanisms of Ageing and Development, 2005 Jan;126(1):111-7.

  65. d'Adda di Fagagna F., Teo Soo-Hwang and Jackson S.P.
    Functional links between telomeres and proteins of the DNA-damage response.
    Genes Development 2004; 18: 1781-1799.

  66. d'Adda di Fagagna F., Reaper P.M., Clay-Farrace L., Fiegler H., Carr P., von Zglinicki T., Saretzki G., Carter N.P. and Jackson S.P.
    A DNA damage checkpoint-mediated response in telomere-initiated senescence.
    Nature 2003; 426: 194-8

  67. Weller G.R., Kysela B., Roy R., Tonkin L.M., Scanlan E., Della M., Devine S.K., Day J.P., Wilkinson A., d'Adda di Fagagna F., Devine K.M., Bowater R.P., Jeggo P.A., Jackson S.P., Doherty A.J.
    Identification of a DNA nonhomologous end-joining complex in bacteria.
    Science 2002;297:1686-9.

  68. d'Adda di Fagagna F., Hande M.P., Tong W-M., Roth D., Lansdorp P.M., Wang Z-Q. and Jackson S.P.
    Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells.
    Current Biology 2001; 11:1192-96.

  69. d'Adda di Fagagna F., Hande M.P., Tong W-M., Lansdorp P.M., Wang Z-Q. and Jackson S.P.
    Functions of Poly(ADP-ribose) polymerase in telomere length control and chromosomal stability.
    Nature Genetics 1999; 23: 76-80.