G.V. Shivashankar is currently the Deputy Director of Mechanobiology Institute (MBI), National University of Singapore, Singapore. He is also heading the Joint Research Laboratory between IFOM and MBI that is focused on understanding the role of nuclear mechanics in Cancer.
Shivashankar laboratory is interested in understanding the impact of cell-geometric constraints on nuclear mechanics and genome regulation in living cells. read more
Mechanical signals from the extracellular matrix impinge on cellular geometry resulting in altered functional nuclear landscape and gene expression programs. These alterations regulate diverse biological processes including stem-cell differentiation, developmental genetic programs and cellular homeostatic control systems. How such signals are integrated to the 3D spatio-temporal organization of the cell nucleus to elicit differential gene expression patterns are poorly understood. read more