IFOM Publications Stefano Casola
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Publications Stefano Casola

  1. Casola S, Perucho L, Tripodo C, Sindaco P, Ponzoni M, Facchetti F.
    The B cell receptor in control of tumor B cell fitness: biology and clinical relevance.
    Immunol. Rev. 2019.

  2. Vernieri C, Pusceddu S, Fucà G, Indelicato P, Centonze G, Castagnoli L, Ferrari E, Ajazi A, Pupa S, Casola S, Foiani M, Mazzaferro V, Pruneri G, Milione M, de Braud F.
    Impact of systemic and tumor lipid metabolism on everolimus efficacy in advanced pancreatic neuroendocrine tumors (pNETs).
    Int J Cancer. 2018 Dec 5. doi: 10.1002/ijc.32042. PubMed PMID: 30520016.

  3. Riboni M, Minardi S, Pujol R, Azzollini J, Peissel B, Manoukian S, De Vecchi G, Casola S, Hauke J, Richters L, Rhiem K, Schmutzler RK, Wallander K, Törngren T, Borg Å, Radice P, Surrallés J, Hahnen E, Ehrencrona H, Kvist A, Benitez J, Peterlongo P.
    Individuals with FANCM biallelic mutations do not develop Fanconi anemia, but show risk for breast cancer, chemotherapy toxicity and may display chromosome fragility.
    Genet Med. 2017 Aug 24. doi: 10.1038/gim.2017.123. PubMed PMID: 28837162.

  4. Petrocelli V and Casola S.
    Targeting gene function in germinal center B cells: a practical approach.
    Methods Mol Biol. 2017; 1623:209-231. doi: 10.1007/978-1-4939-7095-7_17. PubMed PMID: 28589359.

  5. Varano G, Raffel S, Sormani M, Zanardi F, Lonardi S, Zasada C, Perucho L,Petrocelli V, Haake A, Lee AK, Bugatti M, Paul U, Van Anken E, Pasqualucci L, Rabadan R, Siebert R, Kempa S, Ponzoni M, Facchetti F, Rajewsky K, Casola S.
    The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition.
    Nature. 2017 Jun 8;546(7657):302-306. doi: 10.1038/nature22353. PubMed PMID: 28562582.

  6. Wanke F, Moos S, Croxford AL, Heinen AP, Gräf S, Kalt B, Tischner D, Zhang J, Christen I, Bruttger J, Yogev N, Tang Y, Zayoud M, Israel N, Karram K, Reißig S, Lacher SM, Reichhold C, Mufazalov IA, Ben-Nun A, Kuhlmann T, Wettschureck N, Sailer AW, Rajewsky K, Casola S*, Waisman A*, Kurschus FC*.
    EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T
    Cells. Cell Rep. 2017 Jan 31;18(5):1270-1284. doi: 10.1016/j.celrep.2017.01.020.
    *corresponding author

  7. Vernieri C, Casola S, Foiani M, Pietrantonio F, de Braud F, Longo V.
    Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions.
    Cancer Discov. 2016 Dec;6(12):1315-1333. PubMed PMID: 27872127.

  8. Mihailovich M, Bremang M, Spadotto V, Musiani D, Vitale E, Varano G, Zambelli F, Mancuso FM, Cairns DA, Pavesi G, Casola S, Bonaldi T.
    miR-17-92 fine-tunes MYC expression and function to ensure optimal B cell lymphoma growth.
    Nat Commun. 2015 Nov 10;6:8725. doi: 10.1038/ncomms9725. PubMed PMID: 26555894.

  9. Kumar R, Bach MP, Mainoldi F, Maruya M, Kishigami S, Jumaa H, Wakayama T, Kanagawa O, Fagarasan S, Casola S.
    Antibody repertoire diversification through VH gene replacement in mice cloned from an IgA plasma cell.
    Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E450-7. doi: 10.1073/pnas.1417988112. Epub 2015 Jan 21. PubMed PMID: 25609671.

  10. Alberghini F, Petrocelli V, Rahmat M, Casola S.
    An epigenetic view of B-cell disorders.
    Immunol Cell Biol. 2015 Mar;93(3):253-60. doi: 10.1038/icb.2014.116. Epub 2015 Jan 20. Review. PubMed PMID: 25601271.

  11. Simonetti G, Bertilaccio MT, Rodriguez TV, Apollonio B, Dagklis A, Rocchi M, Innocenzi A, Casola S, Winkler TH, Nitschke L, Ponzoni M, Caligaris-Cappio F, Ghia P.
    SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders.
    Haematologica. 2014 Aug;99(8):1356-64. doi: 10.3324/haematol.2013.100230. Epub 2014 May 23. PubMed PMID: 24859880.

  12. Piunti A, Rossi A, Cerutti A, Albert M, Jammula SG, Scelfo A, Cedrone L, Fragola G, Olsson L, Koseki H, Testa G, Casola S, Helin K, D'Adda di Fagagna F and Diego Pasini
    Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication.
    Nat Commun. 2014. Nat Commun. 2014 Apr 14;5:3649. doi: 10.1038/ncomms4649

  13. Colombo E, Tentorio P, Musio S, Rajewsky K, Pedotti R, Casola S, Farina C.
    Skewed B cell differentiation affects lymphoid organogenesis but not T cell-mediated autoimmunity.
    Clin Exp Immunol. 2014 Apr;176(1):58-65. doi: 10.1111/cei.12250

  14. Caganova M, Carrisi C, Varano G, Mainoldi F, Zanardi F, Germain PL, George L, Alberghini F, Ferrarini L, Talukder AK, Ponzoni M, Testa G, Nojima T, Doglioni C Kitamura D, Toellner KM, Su IS, Casola S.
    Germinal center dysregulation by histone methyltrasferase EZH2 promotes lymphomagenesis.
    J Clin Invest. 2013 Dec 2;123(12):5009-22. doi:10.1172/JCI70626. Epub 2013 Nov 8.

  15. Fogli LK, Sundrud MS, Goel S, Bajwa S, Jensen K, Derudder E, Sun A, Coffre M, Uyttenhove C, Van Snick J, Schmidt-Supprian M, Rao A, Grunig G, Durbin J, Casola S, Rajewsky K, Koralov SB.
    T Cell-derived IL-17 mediates Epithelial changes in the airway and drives pulmonary neutrophilia.
    J Immunol. 2013;191(6):3100-11

  16. Fragola G, Germain PL, Laise P, Cuomo A, Blasimme A, Gross F, Signaroldi E, Bucci G, Sommer C, Pruneri G, Mazzarol G, Bonaldi T, Mostoslavsky G, Casola S*, Testa G*.
    Cell reprogramming requires silencing of a core subset of polycomb targets.
    PLoS Genet. 2013 Feb;9(2).
    * corresponding author.

  17. Pengo N, Scolari M, Oliva L, Milan E, Mainoldi F, Raimondi A, Fagioli C, Merlini A, Mariani E, Pasqualetto E, Orfanelli U, Ponzoni M, Sitia R, Casola S, Cenci S.
    Plasma cells require autophagy for sustainable immunoglobulin production.
    Nat Immunol. 2013 Mar;14(3):298-305.

  18. Lechouane F, Bonaud A, Delpy L, Casola S, Oruc Z, Chemin G, Cogné M, Sirac C.
    B-cell receptor signal strength influences terminal differentiation.
    Eur J Immunol. 2013 Mar;43(3):619-28.

  19. Pozzi B, Amodio S, Lucano C, Sciullo A, Ronzoni S, Castelletti D, Adler T, Treise I, Betsholtz IH, Rathkolb B, Busch DH, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Betsholtz C, Casola S, Di Fiore PP, Offenhäuser N.
    The endocytic adaptor Eps15 controls marginal zone B cell numbers.
    PLoS One. 2012;7(11):e50818.

  20. Burgold T, Voituron N, Caganova M, Tripathi PP, Menuet C, Khoramian Tusi B, Spreafico F, Bevengut M, Gestreau C, Buontempo S, Simeone A, Kruidenier L, Natoli G, Casola S. Hilaire G, Testa G.
    The histone H3 lysine 27-demethylase jmjd3 is required for maintenance of the embryonic respiratory neural network, neonatal breathing, and survival.
    Cell Rep. 2012 Nov 29;2(5):1244-58

  21. Zhang B*, Kracker S*, Yasuda T*, Casola S*, Vanneman M, Hömig-Hölzel C, Wang Z, Derudder E, Li S, Chakraborty T, Cotter SE, Koyama S, Currie T, Freeman GJ, Kutok JL, Rodig SJ, Dranoff G and Rajewsky K.
    Immune Surveillance and Therapy of Lymphomas Driven by Epstein-Barr Virus Protein LMP1 in a Mouse Model.
    Cell, 2012 February; 148 (4): 739-751
    * contributed equally

  22. Sakurai N, Maeda M, Lee SU, Ishikawa Y, Li M, Williams JC, Wang L, Su L, Suzuki M, Saito TI, Chiba S, Casola S, Yagita H, Teruya-Feldstein J, Tsuzuki S, Bhatia R, Maeda T.
    The LRF transcription factor regulates mature B cell development and the germinal center response in mice.
    J Clin Invest. 2011 July;121 (7):2583-98.

  23. Pasi CE, Dereli-öz A, Negrini S, Friedli M, Fragola G, Lombardo A, Van Houwe G, Naldini L, Casola S, Testa G, Trono D, Pelicci PG, Halazonetis TD.
    Genomic instability in induced stem cells.
    Cell Death Differ. 2011 May; 18(5): 745-53.

  24. Casola S.
    Mouse models for miRNA expression: the ROSA26 locus.
    Methods Mol Biol. 2010; 667: 145-63.

  25. Grazini U, Zanardi F, Citterio E, Casola S, Goding CR, McBlane F.
    The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining.
    Mol Cell. 2010 Jan 29;37(2):282-93.

  26. Omoei D, Acampora D, Russo F, De Filippi R, Severino V, Di Francia R, frigeri F, Mancuso P, De Chiara A, Pinto* A, Casola S*, Simeone A*.
    Expression of the brain transcription factor OTX1 occurs in a subset of normal germinal-center B cells and in aggressive Non-Hodgkin Lymphoma.
    Am J Pathol. 2009 Dec;175(6):2609-17.
    * Corresponding author

  27. De Santa F, Narang V, Yap ZH, Tusi BK, Burgold T, Austenaa L, Bucci G, Caganova M, Notarbartolo S, Casola S, Testa G, Sung WK, Wei CL, Natoli G.
    Jmjd3 contributes to the control of gene expression in LPS-activated macrophages.
    EMBO J. 2009 Sep 24. [Epub ahead of print]

  28. Hikida M, Casola S, Takahashi N, Kaji T, Takemori T, Rajewsky K, Kurosaki T.
    LC-{gamma}2 is essential for formation and maintenance of memory B cells.
    J Exp Med. 2009 Mar 9. [Epub ahead of print]

  29. Hao Z, Duncan GS, Seagal J, Su YW, Hong C, Haight J, Chen NJ, Elia A, Wakeham A, Li WY, Liepa J, Wood GA, Casola S, Rajewsky K, Mak TW.
    Fas Receptor Expression in Germinal-Center B Cells Is Essential for T and B Lymphocyte Homeostasis.
    Immunity. Oct;29(4):615-27, 2008.

  30. Hömig-Hölzel C, Hojer C, Rastelli J, Casola S, Strobl LJ, Müller W, Quintanilla-Martinez L, Gewies A, Ruland J, Rajewsky K, Zimber-Strobl U.
    Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis.
    J Exp Med. Jun 9;205(6):1317-29. Epub 2008 May 19, 2008.

  31. Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K.
    Regulation of the germinal center response by microRNA-155.
    Science; 316(5824):604-8, 2007.

  32. Casola S.
    Control of peripheral B-cell development.
    Curr Opin Immunol. Apr;19(2):143-9, 2007.

  33. Casola S and Rajewsky K.
    B cell recruitment and selection in mouse GALT germinal centres.
    Curr Top Microbiol Immunol; 308:155-171, 2006.

  34. Klein U, Casola S., Cattoretti G, Shen Q, Lia M, Mo T, Ludwig T, Rajewsky K and Dalla-Favera R.
    Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.
    Nat Immunol. 7(7):773-82, 2006.

  35. Casola S, Cattoretti G, Uyttersprot N, Koralov SB, Segal J, Hao Z, Waisman A, Egert A, Ghitza D and Rajewsky K.
    Tracking germinal center B cells expressing germ-line immunoglobulin {gamma}1 transcripts by conditional gene targeting.
    Proc Natl Acad Sci U S A. 103(19): 7396-401, 2006.

  36. Novobrantseva TI, Majeau GR, Amatucci A, Kogan S, Brenner I, Casola S, Shlomchik MJ, Koteliansky V, Hochman PS and Ibraghimov A.
    Attenuated liver fibrosis in the absence of B cells.
    J Clin Invest. 115 (11):3072-82, 2005.

  37. Sasaki Y, Casola S., Kutok JL, Rajewsky K and Schmidt-Supprian M.
    BAFF-R-dependent and -independent roles in B cell physiology.
    J Immunol. 173(4),2245-52, 2004.

  38. Schmidt-Supprian M, Tian J, Ji H, Terhorst C, Bhan AK, Grant EP, Pasparakis M, Casola S., Coyle AJ and Rajewsky K.
    IKK2-deficiency in T cells leads to defects in priming, B cell help, germinal center reactions and homeostatic expansion.
    J Immunol. 173(3),1612-19, 2004.

  39. Casola S.
    Conditional gene mutagenesis in B lineage cells.
    Methods Mol Biol. Humana Press; 271, 91-109, 2004.

  40. Casola S, Otipoby KL, Alimzhanov M, Humme S, Uyttersprot N, Kutok JL, Carroll MC and Rajewsky K.
    B cell receptor signal strength determines B cell fate.
    Nat Immunol. 5(3), 317-27, 2004.

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