IFOM Pubblicazioni Simona Polo

Pubblicazioni Simona polo

  1. Wollscheid HP, Biancospino M, He F, Magistrati E, Molteni E, Lupia M, Soffientini P, Rottner K, Cavallaro U, Pozzoli U, Mapelli M, Walters KJ, Polo S.
    Diverse functions of myosin VI elucidated by an isoform-specific ?-helix domain.
    Nat Struct Mol Biol. 2016 Apr;23(4):300-8. doi: 10.1038/nsmb.3187. Epub 2016 Mar 7.

  2. He F, Wollscheid HP, Nowicka U, Biancospino M, Valentini E, Ehlinger A, Acconcia F, Magistrati E, Polo S*, Walters KJ*
    Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains.
    Cell Rep. 2016 Mar 22;14(11):2683-94. doi: 10.1016/j.celrep.2016.01.079. Epub 2016 Mar 10.
    * corresponding author

  3. Savio MG, Wollscheid N, Cavallaro E, Algisi V, Di Fiore PP, Sigismund S, Maspero E, Polo S.
    USP9X Controls EGFR Fate by Deubiquitinating the Endocytic Adaptor Eps15.
    Curr Biol. 2016 Jan 25;26(2):173-83. doi: 10.1016/j.cub.2015.11.050. Epub 2015 Dec 31.

  4. Capuani F, Conte A, Argenzio E, Marchetti L, Priami C, Polo S, Di Fiore PP, Sigismund S, Ciliberto A.
    Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells.
    Nat Commun. 2015 Aug 12;6:7999. doi: 10.1038/ncomms8999.

  5. Mari S, Ruetalo N, Maspero E, Stoffregen MC, Pasqualato S, Polo S*, Wiesner S*
    Structural and functional framework for the autoinhibition of Nedd4-family ubiquitin ligases.
    Structure. 2014 Nov 4;22(11):1639-49. doi: 10.1016/j.str.2014.09.006. Epub 2014 Oct 30.
    * corresponding author

  6. Persaud A, Alberts P, Mari S, Tong J, Murchie R, Maspero E, Safi F, Moran MF, Polo S, Rotin D.
    Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity.
    Sci Signal. 2014 Oct 7;7(346):ra95. doi: 10.1126/scisignal.2005290.

  7. Boissan M, Montagnac G, Shen Q, Griparic L, Guitton J, Romao M, Sauvonnet N, Lagache T, Lascu I, Raposo G, Desbourdes C, Schlattner U, Lacombe ML, Polo S, van der Bliek AM, Roux A, Chavrier P.
    Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling.
    Science. 2014 Jun 27;344(6191):1510-5. doi: 10.1126/science.1253768.

  8. Polo S, Di Fiore PP, Sigismund S.
    Keeping EGFR signaling in check: ubiquitin is the guardian.
    Cell Cycle. 2014;13(5):681-2. doi: 10.4161/cc.27855. Epub 2014 Jan 21.

  9. Sigismund S, Algisi V, Nappo G, Conte A, Pascolutti R, Cuomo A, Bonaldi T, Argenzio E, Verhoef LG, Maspero E, Bianchi F, Capuani F, Ciliberto A, Polo S*, Di Fiore PP.*
    Threshold-controlled ubiquitination of the EGFR directs receptor fate.
    EMBO J. 2013 Jul 31;32(15):2140-57. doi: 10.1038/emboj.2013.149. Epub 2013 Jun 25. PMID: 23799367 [PubMed - indexed for MEDLINE]
    * corresponding author.

  10. Sorrentino V, Nelson JK, Maspero E, Marques AR, Scheer L, Polo S, Zelcer N.
    The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation.
    J Lipid Res. 2013 Aug;54(8):2174-84. doi: 10.1194/jlr.M037713. Epub 2013 Jun 3. PMID: 23733886 [PubMed - in process]

  11. Maspero E, Valentini E, Mari S, Cecatiello V, Soffientini P, Pasqualato S, Polo S.
    Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.
    Nat Struct Mol Biol. 2013 Jun;20(6):696-701. doi: 10.1038/nsmb.2566. Epub 2013 May 5. PMID: 23644597 [PubMed - indexed for MEDLINE]

  12. Niño CA, Chaparro J, Soffientini P, Polo S*, Wasserman M.*
    Ubiquitination dynamics in the early-branching eukaryote Giardia intestinalis.
    Microbiologyopen. 2013 Jun;2(3):525-39. doi: 10.1002/mbo3.88. Epub 2013 Apr 23. PMID: 23613346 [PubMed - in process]
    * corresponding author.

  13. Polo S.
    Signaling-mediated control of ubiquitin ligases in endocytosis.
    BMC Biol. 2012 Mar 15;10:25. doi: 10.1186/1741-7007-10-25. Review. PMID: 22420864 [PubMed - indexed for MEDLINE]

  14. Sigismund S, Confalonieri S, Ciliberto A, Polo S, Scita G, and Di Fiore PP. P
    Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.
    Physiol Rev. 2012 Jan;92(1):273-366. doi: 10.1152/physrev.00005.2011. Review. PMID: 22298658 [PubMed - indexed for MEDLINE]

  15. Inui M, Manfrin A, Mamidi A, Martello G, Morsut L, Soligo S, Enzo E, Moro S, Polo S, Dupont S, Cordenonsi M, Piccolo S.
    USP15 is a deubiquitylating enzyme for receptor-activated SMADs.
    Nat Cell Biol. 13:1368-75. (2011)

  16. Maspero E, Mari S, Valentini E, Musacchio A, Fish A, Pasqualato S, Polo S.
    Structure of the HECT:Ub complex and its role in ubiquitin chain elongation.
    EMBO Rep. 12: 342-349 (2011)

  17. Argenzio E, Bange T, Oldrini B, Bianchi F, Peesari R, Mari S, Di Fiore PP, Mann M, and Polo S. 
    Proteomic snapshot of the EGF-induced ubiquitin network. 
    Mol Syst Biol. 7:462. (2011)

  18. Frosi Y, Anastasi S, Ballarò C, Varsano G, Castellani L, Maspero E, Polo S, Alemà S, Segatto O.
    A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation. 
    J Cell Biol. 189:557-71. (2010)

  19. Lai FP, Szczodrak M, Oelkers JM, Ladwein M, Acconcia F, Benesch S, Auinger S, Faix J, Small JV, Polo S, Stradal TE, Rottner K. 
    Cortactin promotes migration and platelet-derived growth factor-induced actin reorganization by signaling to Rho-GTPases.
    Mol Biol Cell. 20:3209-23 (2009)

  20. Polo S, Di Fiore PP.
    Finding the right partner: science or ART?
    Cell. Nov 14;135(4):590-2, 2008.

  21. Acconcia F, Sigismund S, Polo S.
    Ubiquitin in trafficking: The network at work.
    Exp Cell Res. Oct 28, 2008

  22. Sigismund S, Argenzio E, Tosoni D, Cavallaro E, Polo S*, Di Fiore PP.*
    Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation.
    Dev Cell. Aug;15(2):209-19, 2008.

  23. Woelk T, Sigismund S, Penengo L, Polo S.
    The ubiquitination code: a signalling problem.
    Cell Div. Mar 13;2:11, 2007.

  24. Woelk T, Oldrini B, Maspero E, Confalonieri S, Cavallaro E, Di Fiore PP, Polo S.
    Molecular mechanisms of coupled monoubiquitination
    Nat Cell Biol, 8:1246-54, 2006.

  25. Polo S, Di Fiore PP.
    Endocytosis conducts the cell signaling orchestra.
    Cell. Mar 10;124(5):897-900, 2006.

  26. Penengo L, Mapelli M, Murachelli AG, Confalonieri S, Magri L, Musacchio A, Di Fiore PP, Polo S*, Schneider TR.*
    Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin.
    2006 Mar 24;124(6):1183-95 Cell.
    * corresponding author.

  27. Innocenti M, Gerboth S, Rottner K, Lai FP, Hertzog M, Stradal TE, Frittoli E, Didry D, Polo S, Disanza A, Benesch S, Di Fiore PP, Carlier MF, Scita G.
    Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes.
    Nat Cell Biol. Oct;7(10):969-76, 2005.

  28. Mao Y, Senic-Matuglia F, Di Fiore PP, Polo S, Hodsdon ME, De Camilli P.
    Deubiquitinating function of ataxin-3: Insights from the solution structure of the Josephin domain.
    Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12700-5. Epub 2005 Aug 23.

  29. Benesch S, Polo S, Lai F, Anderson K, Stradal T, Wehland J and Rottner K.
    N-WASP deficiency impairs EGF internalization and actin assembly at clathrin coated pits.
    JCS, 118: 3103-15, 2005.

  30. Sigismund S, Woelk T, Puri C, Maspero E, Tacchetti C, Transidico P, Di Fiore PP and Polo S.
    Clathrin-independent endocytosis of ubiquitinated cargos.
    Proc Natl Acad Sci U S A., 102: 2760-5 2005.

  31. Sigismund S, Polo S, Di Fiore PP.
    Signaling through monoubiquitination
    Curr Top Microbiol. Immunol. 286: 149-85, 2004.

  32. Polo S, Pece S, Di Fiore PP.
    Endocytosis and cancer
    Curr Opin Cell Biol. 16: 156-61, 2004.

  33. Polo S, Confalonieri S, Salcini AE, Di Fiore PP.
    EH and UIM: endocytosis and more
    Sci STKE. 213: re17, 2003.

  34. Chen H, Polo S, Di Fiore PP, De Camilli PV.
    Rapid Ca2+-dependent decrease of protein ubiquitination at synapses.
    Proc Natl Acad Sci U S A. 100: 14908-13, 2003.

  35. Haglund K, Sigismund S, Polo S, Szymkiewiczi I, Di Fiore PP and Dikic I.
    Multiple monoubiquitination of receptor tyrosine kinases is sufficient for their endocytosis and degradation.
    Nat Cell Biol. 5:461-6, 2003.

  36. Bianchi E., Denti S., Catena R., Rossetti G., Polo S., Gasparian S., Putignano S., Rogge L. and Pardi R.
    Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity.
    JBC. 278:19682-90, 2003.

  37. Di Fiore PP, Polo S, Hofmann K.
    When Ubiquitin meets Ubiquitin Receptors: a signalling connection.
    Nat. Mol. Cell Biol. Review 6:491-7, 2003.

  38. Polo S, Sigismund S, Faretta M, Guidi M, Capua MR, Bossi G, Chen H, De Camilli P, Di Fiore PP.
    A single motif responsible for both ubiquitin recognition and monoubiquitination in endocytic proteins.
    Nature 416:451-5, 2002