Pubblicazioni
L’impatto scientifico della ricerca di IFOM
L’impatto scientifico esprime l’influenza e la rilevanza delle scoperte e delle pubblicazioni di un Istituto di ricerca.
Per IFOM si misura soprattutto attraverso la qualità delle pubblicazioni, la visibilità internazionale e la capacità di generare conoscenze utili per avanzamenti concreti nella lotta contro il cancro.
Nel 2025 la produzione scientifica di IFOM si è attestata su 140 documenti, fra cui figurano 121 articoli (86,43%) e 19 review (13,57%) pubblicati su riviste internazionali.
Delle 140 pubblicazioni scientifiche, 56 (40%) riportano una scienziata o uno scienziato di IFOM come prima o ultima firma o corresponding author, ovvero coloro che hanno contribuito maggiormente allo studio.
Tra gli studi pubblicati da IFOM nel 2025, 64 sono stati pubblicati su riviste che fanno parte dei gruppi editoriali come Springer Nature, rappresentando circa il 46% del totale delle pubblicazioni dell’anno.
Di questi, quasi il 36% vedono come prima o ultima firma una scienziata o uno scienziato di IFOM.
IFOM punta a rendere le sue pubblicazioni accessibili al più ampio pubblico possibile attraverso una politica di Open Access, ovvero liberamente accessibili online, senza restrizioni di accesso.
Nel 2025, l’81% degli studi pubblicati è stato reso accessibile su riviste Open Access, garantendo che le scoperte di IFOM possano contribuire al progresso scientifico globale e raggiungere un’ampia comunità di ricercatori, clinici e pazienti.
Pubblicazioni 2025
Ultimo aggiornamento: Maggio 2026
- Adaptive plasticity in targeted therapy.
Vito Amodio; Giorgio Patelli; Alberto Bardelli
(2025) Cancer cell 2026 Jan 12 - Epub 2025 Dec 31 10.1016/j.ccell.2025.12.007 [41478275] - p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism.
Kathrin Laue; Sabina Pozzi; Johanna Zerbib; Rebecca Bertolio; Yonatan Eliezer; Yael Cohen-Sharir; Tom Winkler; Manuel Caputo; Alessia A Ricci; Lital Adler; Rami Khoury; Giuseppe Longobardi; Rachel Slutsky; Alicia I Leikin-Frenkel; Shai Ovadia; Katharina Lange; Alessandra Rustighi; Silvano Piazza; Andrea Sacconi; Rayna Y Magesh; Faith N Keller; Jean Berthelet; Alexander Schäffer; Ron Saad; Sahar Israeli Dangoor; Karolina Szczepanowska; Iris Barshack; Yang Liao; Sergey Malitsky; Alexander Brandis; Thomas Broggini; Marcus Czabanka; Wei Shi; Delphine Merino; Emma V Watson; Giovanni Blandino; Ayelet Erez; Ruth Ashery-Padan; Hind Medyouf; Luca Bertero; Giannino Del Sal; Ronit Satchi-Fainaro; Uri Ben-David
(2025) Nature genetics 2026 Jan - Epub 2025 Dec 29 10.1038/s41588-025-02446-1 [41461910] - The Janus framework of the integrated stress response: from homeostasis to maladaptation.
Dogus M Altintas; Marina Cerqua; Paolo M Comoglio; Cédric Chaveroux
(2025) Life science alliance 2026 Mar - Epub 2025 Dec 29 10.26508/lsa.202503523 [41461564] - Aging well in an aging society: Italy at the forefront of global aging and the Age-It Research Program.
Daniele Vignoli; Marco Albertini; Carlos Chiatti; Gianluca Aimaretti; Giovanna Boccuzzo; Vanna Boffo; Agar Brugiavini; Filippo Cavallo; Simone Cenci; Antonio Cherubini; Febo Cincotti; Fabrizio d'Adda di Fagagna; Carlo Ferrarese; Vincenzo Galasso; Elisabetta Galeotti; Andrea Graziani; Guido Iaccarino; Fabrizia Lattanzio; Claudio Lucifora; Mario Mezzanzanica; Giuseppe Passarino; Anna Paterno; Sabrina Prati; Raffaella I Rumiati; Marco Sandri; Cecilia Tomassini; Alexandra Torbica; Andrea Ungar; Alessandra Petrucci
(2025) The journals of gerontology. Series B, Psychological sciences and social sciences 2025 Dec 01 10.1093/geronb/gbaf219 [41442765] - Improving our understanding of the biology of aging: findings from the Age-It Research Program.
Fabrizio Chiti; Fiorenzo Conti; Daniela Corda; Francesco Giorgino; Andrea Graziani; Giuseppe Passarino; Marco Sandri; Fabrizio d'Adda di Fagagna
(2025) The journals of gerontology. Series B, Psychological sciences and social sciences 2025 Dec 01 10.1093/geronb/gbaf197 [41442755] - De Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems.
Hind Abdo; Leonardo Barzaghi; Yuan Shen; Edoardo Bellini; Emanuele Martini; Serena Magni; Sara Barozzi; Fabrizio Orsenigo; Dario Parazzoli; Galina V Beznoussenko; Jasmin Di Franco; Fabian Krautgasser; Jasmin Kaivola; Mario Cinquanta; Alessandro Lazzarin; Sara Sigismund; Johanna Ivaska; Roberto Cerbino; Giorgio Scita
(2025) Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec 23 10.1002/advs.202508648 [41431893] - Single cell RNAseq signatures refined with combiroc enhance identification of NK cells in blood and solid tissues.
Ivan Ferrari; Saveria Mazzara; Andrea Gobbini; Noemi Di Marzo; Mariacristina Crosti; Sergio Abrignani; Renata Grifantini; Mauro Bombaci; Riccardo L Rossi
(2025) Scientific reports 2025 Dec 18 10.1038/s41598-025-29876-5 [41413116] - Brillouin Microscopy of Breast tumor Spheroids On-a-Chip: Mechanical and Transcriptional Responses to Microfluidic-Induced Rapid Deformations.
Mona Makkieh; Alessandra Anna Passeri; Davide Lazzari; Stefano Marchesi; Andrea Disanza; Rafal Khaled Ahmad Salem; Francesco Bonacci; Camillo Mazzella; Emanuele Martini; Mattia Tonani; Leonardo Donati; Edoardo Bellini; Hind Abdo; Judith Pineau; Serena Magni; Fabrizio Orsenigo; Matthieu Piel; Daniele Fioretto; Sabata Martino; Maurizio Mattarelli; Giorgio Scita; Brenda J Green; Silvia Caponi
(2025) Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan - Epub 2025 Dec 16 10.1002/advs.202513153 [41399996] - An organotypic model of ductular reaction reveals a mevalonate-dependent vulnerability in reactive biliary cells.
Beatrice Anfuso; Suresh Velnati; Davide Selvestrel; Clara Garlant; Elisa Ferracci; Gabriele Baj; Pietro Parisse; Diletta Overi; Rebecca Bertolio; Roberta Bulla; Aurelio Sonzogni; Matteo Bramuzzo; Loredana Casalis; Nicholas Cocomello; Francesco Baratta; Maria Del Ben; Pablo Giraudi; Claudio Tiribelli; Natalia Rosso; Manuela Mastronardi; Paola Tarchi; Maurizio Pinamonti; Fabrizio Zanconati; Nicolò de Manzini; Eugenio Gaudio; Silvia Palmisano; Deborah Bonazza; Giannino Del Sal; Guido Carpino; Fulvio Chiacchiera; Giovanni Sorrentino
(2025) Cell reports 2025 Dec 23 10.1016/j.celrep.2025.116681 [41389211] - A human CAGinSTEM? platform for decoding HTT repeats' somatic instability links CAG interruption to HD pathology in neurons.
Martina Zobel; Gianluca Damaggio; Maria Lidia Mignogna; Dario Besusso; Davide Scalzo; Andrea Cossu; Camilla Trovesi; Mariacristina Crosti; Francesco Cortina; Ilaria Campus; Giulio Formenti; Saveria Mazzara; Francesco Gregoretti; Laura Antonelli; Gennaro Oliva; Chiara Zuccato; Vincenza Colonna; Paola Conforti; Matteo Cereda; Riccardo Lorenzo Rossi; Simone Maestri; Andrea Scolz; Raffale Iennaco; Elena Cattaneo
(2025) Cell reports 2025 Dec 23 10.1016/j.celrep.2025.116685 [41389205] - High-Throughput Molecular Characterization of the Microbiome in Breast Implant-Associated Anaplastic Large Cell Lymphoma and Peri-Implant Benign Seromas.
Evelina Rogges; Giorgio Bertolazzi; Davide Vacca; Marina Borro; Gianluca Lopez; Maurizio Simmaco; Anna Scattone; Guido Firmani; Michail Sorotos; Fabio Santanelli di Pompeo; Niccolò Noccioli; Emanuele Savino; Andrea Vecchione; Arianna Di Napoli
(2025) Cancers 2025 Nov 29 10.3390/cancers17233839 [41375040] - Fasting boosts breast cancer therapy efficacy via glucocorticoid activation.
Nuno Padrão; Tesa M Severson; Sebastian Gregoricchio; Ana Guijarro; Catrin Lutz; Daniel Taranto; Stefan Hutten; Francesca Ligorio; Angelica Persia; Merel Roest; Joyce Sanders; Ji-Ying Song; Sara Pires-Oliveira; Maria Donaldson Collier; Hugo Horlings; Livia Pisciotta; Filippo de Braud; Claudio Vernieri; Leila Akkari; Jos Jonkers; Alessio Nencioni; Irene Caffa; Wilbert Zwart
(2025) Nature 2026 Jan - Epub 2025 Dec 10 10.1038/s41586-025-09869-0 [41372410] - DROSHA, DICER, and damage-induced long ncRNA control BMI1-dependent transcriptional repression at DNA double-strand break.
Francesca Esposito; Ilaria Capozzo; Adelaide Riccardi; Ubaldo Gioia; Stefania Modafferi; Letizia Manfredi; Alessio Colantoni; Sara Tavella; Matteo Cabrini; Fabio Iannelli; Alessia di Lillo; Fabrizio d'Adda di Fagagna; Sofia Francia
(2025) Cell reports 2025 Dec 23 10.1016/j.celrep.2025.116605 [41348540] - Partial Alopecia Area Retains Bulge Hair Follicle Progenitor Cells in Indian Androgenetic Alopecia Patients.
Akshay Hegde; Dyuti Saha; Savitha Somaiah; Colin Jamora
(2025) International journal of trichology 2025 10.4103/ijt.ijt_27_24 [41346559] - miR-382-5p and miR-34a in migraine: Expression in monocytes and a post-hoc exploratory comparison with expression in peripheral blood mononuclear cells.
Rosaria Greco; Federico Bighiani; Chiara Demartini; Annamaria Zanaboni; Miriam Francavilla; Sara Facchetti; Daisy Sproviero; Gloria Vaghi; Marta Allena; Daniele Martinelli; Michele Corrado; Elena Guaschino; Natascia Ghiotto; Sara Bottiroli; Francescantonio Cammarota; Alessandro Antoniazzi; Valentina Grillo; Grazia Sances; Cristina Tassorelli; Roberto De Icco
(2025) Cephalalgia : an international journal of headache 2025 Dec 10.1177/03331024251386769 [41342643] - Epigenetic drivers of chromosomal instability.
Ilio Vitale; Matteo Cereda; Lorenzo Galluzzi
(2025) Trends in cancer 2025 Dec 02 10.1016/j.trecan.2025.11.010 [41339187] - Efficacy and safety of atezolizumab plus bevacizumab in MSI-like metastatic colorectal cancer: a multicenter, single-arm, phase II, open-label clinical trial.
E Elez; S Siena; A Sartore-Bianchi; J Ros; F Ciardello; E Martinelli; N Steeghs; S Huijberts; A Cervantes; S Roselló; S Tejpar; B Wilmsen; R Salazar; C Santos; G de Schaetzen; S Muñoz; R Bernards; V Moreno; E García-Galera; R Alemany; A Gros; A Bardelli; S Arena; A Piris; E Chavarría; R Dienstmann; J Tabernero
(2025) ESMO open 2025 Dec 10.1016/j.esmoop.2025.105892 [41337858] - A subset of MMR-proficient colon cancers responds to neoadjuvant immunotherapy.
Eleonora Piumatti; Giovanni Germano; Pietro Paolo Vitiello; Alberto Bardelli
(2025) Molecular oncology 2025 Nov 30 10.1002/1878-0261.70178 [41321030] - Localized Wnt-signaling promotes asymmetric NuMA?-dependent oriented divisions and unequal apportioning of mitochondria.
Susanna Eli; Greta Rauso; Paola Ghezzi; James L A Szczerkowski; Michela Bruzzi; Francesca Rizzelli; Fabiola Iommazzo; Alessia Loffreda; Francesco Castagna; Federico Donà; Chiara Gaddoni; Ambra Dondi; Mattia Marenda; Simona Rodighiero; Pierre Tournier; Zeno Lavagnino; Dario Parazzoli; Nils C Gauthier; Simone Tamburri; Diego Pasini; Shukry James Habib; Marina Mapelli
(2025) Nature communications 2025 Nov 27 10.1038/s41467-025-65775-z [41310344] - Total neoadjuvant therapy followed by non-operative management or surgery in stage II-III rectal cancer (NO-CUT): a multicentre, single-arm, phase 2 trial.
Alessio Amatu; Giorgio Patelli; Maria Giulia Zampino; Francesca Bergamo; Stefania Mosconi; Federica Tosi; Davide Ciardiello; Sara Lonardi; Giorgia Negrini; Daniela Sibio; Marianna Alessandra Gerardi; Sara Galuppo; Francesco Romeo Filippone; Pietro Carnevali; Simona Borin; Pierluigi Pilati; Elia Poiasina; Erica Bonazzina; Lorenzo Gervaso; Enzo Mammano; Francesco Bracco; Luca Bergamaschi; Gaya Spolverato; Matteo Origi; Uberto Fumagalli Romario; Gianluca Mauri; Nicola Fazio; Edoardo Forti; Giuseppe De Roberto; Chiara Cristofori; Cesare Burti; Luigi Asmundo; Luigi Funicelli; Gaetano Ramondo; Pietro Andrea Bonaffini; Sara Mariano; Luca Lazzari; Silvia Ghezzi; Claudio Isella; Daniela Cantarella; Maria Costanza Aquilano; Luca Bottiglieri; Emanuela Bonoldi; Massimiliano Mutignani; Valter Torri; Enzo Medico; Alberto Bardelli; Silvia Marsoni; Angelo Vanzulli; Mauro Filippo Palazzi; Giovanni Carlo Ferrari; Katia Bencardino; Andrea Sartore-Bianchi; Salvatore Siena
(2025) The Lancet. Oncology 2025 Dec 10.1016/S1470-2045(25)00542-X [41308677] - Author Correction: A blood-based DNA damage signature in patients with Parkinson's disease is associated with disease progression.
Daisy Sproviero; César Payán-Gómez; Chiara Milanese; Sander Barnhoorn; Shixiang Sun; Akos Gyenis; Domenico Delia; Tammaryn Lashley; Jan H J Hoeijmakers; Jan Vijg; Pier G Mastroberardino
(2025) Nature aging 10.1038/s43587-025-01037-3 [41258491] - IgAim?: cell surface Ig-aimed immune memory erasers for the therapy of autoimmune diseases and B leukemia.
Hiroshi Arakawa
(2025) NAR molecular medicine 2025 Apr 10.1093/narmme/ugaf016 [41255710] - Sentinel Node Biopsy Alone Versus Sentinel Node Biopsy Plus Axillary Dissection in cT2 cN0/1 Breast Cancer After Neoadjuvant Chemotherapy: 15-Year Results of a Prospective Interventional Study.
Gabriele Martelli; Francesco Barretta; Carlo Muzi; Chiara Listorti; Federica Pilotta; Ilaria Maugeri; Chiara Osio; Deborah Bonfili; Claudio Vernieri; Giulia Bianchi; Giancarlo Pruneri; Secondo Folli; Gianfranco Scaperrotta; Paolo Baili; Rosalba Miceli; Cristina Ferraris
(2025) Annals of surgical oncology 2025 Nov 18 10.1245/s10434-025-18673-z [41251914] - Targeting HER2 in Metastatic Colorectal Cancer: Current Therapies, Biomarker Refinement, and Emerging Strategies.
Caterina Vaghi; Federica Tosi; Gianluca Mauri; Erica Bonazzina; Alessio Amatu; Katia Bencardino; Daniele Piscazzi; Laura Roazzi; Federica Villa; Michelangelo Maggi; Letizia Monti; Anna Bombelli; Giovanna Marrapese; Silvia Ghezzi; Giorgio Patelli; Javier Ros; Elena Elez; Andrea Sartore-Bianchi; Salvatore Siena
(2025) Drugs 2026 Jan - Epub 2025 Nov 17 10.1007/s40265-025-02253-2 [41247589] - Large-scale meta-analysis and precision functional assays identify FANCM regions in which PTVs confer different risks for ER-negative and triple-negative breast cancer.
Amandine Billaud; Gisella Figlioli; Clémence Mooser; Irene Casamassima; Violette Azzoni; Jahnavi Srivatsa; Mara Colombo; Laura Caleca; Thomas U Ahearn; Irene L Andrulis; Antonis C Antoniou; Matthias W Beckmann; Sabine Behrens; Marina Bermisheva; Natalia V Bogdanova; Manjeet K Bolla; Bernardo Bonanni; Thomas Brüning; Nicola J Camp; Archie Campbell; Jose E Castelao; Melissa H Cessna; Jenny Chang-Claude; NBCS Collaborators; Kamila Czene; Joe Dennis; Peter Devilee; Thilo Dörk; Alison M Dunning; Mikael Eriksson; D Gareth Evans; Peter A Fasching; Jonine D Figueroa; Marike Gabrielson; Manuela Gago-Dominguez; Anna González-Neira; Pascal Guénel; Andreas Hadjisavvas; Eric Hahnen; Ute Hamann; Peter Hillemanns; Antoinette Hollestelle; Maartje J Hooning; Reiner Hoppe; Anthony Howell; kConFab Investigators; Anna Jakubowska; Vessela N Kristensen; Jan Lubi?ski; Michael Lush; Siranoush Manoukian; Dimitrios Mavroudis; Roger L Milne; Anna Marie Mulligan; William G Newman; Nadia Obi; Mihalis I Panayiotidis; Guillermo Pita; Muhammad U Rashid; Valerie Rhenius; Emmanouil Saloustros; Elinor J Sawyer; Rita K Schmutzler; Mitul Shah; Melissa C Southey; Amanda B Spurdle; Ian Tomlinson; Thérèse Truong; Qin Wang; Camilla Wendt; Paul L Auer; Nicholas J Boddicker; Clara Bodelon; Elizabeth S Burnside; Fei Chen; Fergus J Couch; Susan M Domchek; Heather A Eliassen; Christopher Haiman; James M Hodge; Chunling Hu; Hongyan Huang; Sara Lindstrom; Maria Elena Martinez; Katherine L Nathanson; Susan L Neuhausen; Katie M O'Brien; Janet E Olson; Julie R Palmer; Alpa V Patel; Kathryn J Ruddy; Dale P Sandler; Lauren R Teras; Clarice R Weinberg; Jeffrey N Weitzel; Stacey J Winham; Siddhartha Yadav; Song Yao; Gary Zirpoli; Marketa Janatova; Zdenek Kleibl; Petra Kleiblova; Jana Soukupova; CZECANCA consortium; Qihong Zhao; Lisa Devereux; Paul A James; Ian G Campbell; Tu Nguyen-Dumont; James G Dowty; Nadine Andrieu; Fabienne Lesueur; Dominique Stoppa-Lyonnet; GENESIS; Miguel de la Hoya; Paolo Radice; Claus Storgaard Sørensen; Paolo Peterlongo
(2025) Breast (Edinburgh, Scotland) 2025 Oct 30 10.1016/j.breast.2025.104619 [41223770] - Ubiquitin choreography in nasopharyngeal carcinoma: USP18 scaffolds radioresistance.
Francesco Napoletano; Rebecca Bertolio; Giannino Del Sal
(2025) Cell death and differentiation 2025 Nov 11 10.1038/s41418-025-01616-2 [41219492] - The E3 ligase RNF32 controls the IκB kinase complex and NF-κB signaling in intestinal stem cells.
Angela Lauriola; Juliana Haydeé Enriqué Steinberg; Motoharu Sarubo; Elena Maspero; Fabiana Alejandra Rossi; Yasuhiro Mouri; Marco Pedretti; Mohsen Hajisadeghian; Vincenzo Taibi; Andrea Vettori; Nicola Vitulo; Michael Assfalg; Mariapina D'Onofrio; Mario Rossi; Akihiro Yasue; Alessandra Astegno; Simona Polo; Spartaco Santi; Yasusei Kudo; Daniele Guardavaccaro
(2025) Molecular cell 2025 Nov 20 10.1016/j.molcel.2025.10.005 [41167191] - Clinical Actionability of Genes in Gastrointestinal Tumors.
Nadia Saoudi Gonzalez; Giorgio Patelli; Giovanni Crisafulli
(2025) Genes 2025 Sep 25 10.3390/genes16101130 [41153346] - Acquisition of an immunosuppressive microenvironment after anti-CD19 CAR T-cell therapy is associated with T-cell dysfunction and resistance.
Marianna Ponzo; Lorenzo Drufuca; Chiara Buracchi; Marco M Sindoni; Silvia Nucera; Cristina Bugarin; Ramona Bason; Grazisa Rossetti; Raoul Bonnal; Cristian Meli; Benedetta Rambaldi; Federico Lussana; Silvia Ferrari; Alex Moretti; Giuseppe Dastoli; Giulia Risca; Christian Pellegrino; Markus G Manz; Stefania Galimberti; Alessandro Rambaldi; Giuseppe Gaipa; Andrea Biondi; Massimiliano Pagani; Chiara F Magnani
(2025) Journal for immunotherapy of cancer 2025 Oct 23 10.1136/jitc-2025-011768 [41135951] - Chromatin remodeling restrains oncogenic functions in prostate cancer.
Valentina Rosti; Giovanni Lembo; Cristiano Petrini; Francesca Gorini; Roberto Quadri; Chiara Cordiglieri; Margherita Mutarelli; Elisa Salviato; Elisabetta Casari; Emanuele Di Patrizio Soldateschi; Emanuele Montanari; Giancarlo Albo; Francesco Ripa; Alessandra Fasciani; Mariacristina Crosti; Elisa De Lorenzis; Marco Maggioni; Valentina Vaira; Maria Vivo; Francesco Ferrari; Chiara Lanzuolo
(2025) Nature communications 2025 Oct 16 10.1038/s41467-025-64213-4 [41102163] - Efficacy and safety of systemic therapies following progression on CDK4/6 inhibitors in patients with HR+/HER2- metastatic breast cancer: a systematic review and network meta-analysis.
Roberto Buonaiuto; Mario Fordellone; Aldo Caltavituro; Maria Letizia Cataldo; Carmen Criscitiello; Maria Vittoria Dieci; Matteo Lambertini; Andrea Botticelli; Mario Giuliano; Antonio Giordano; Federica Mangiacotti; Angela Grieco; Alessandra Longobardi; Roberta Caputo; Martina Pagliuca; Claudio Vernieri; Luca Malorni; Lorenzo Gerratana; Grazia Arpino; Paolo Chiodini; Michelino De Laurentiis; Carmine De Angelis
(2025) EClinicalMedicine? 2025 Nov 10.1016/j.eclinm.2025.103535 [41079023] - Acetylation of lysine 49 on Ctnnb1 drives naïve pluripotency in murine stem cells by modulating Nanog function.
Toshiyuki Takehara; Mahito Nakanishi; Raku Son; Hirofumi Suemori; Yasuhiro Murakawa; Takeshi Teramura
(2025) PNAS nexus 2025 Oct 10.1093/pnasnexus/pgaf297 [41064241] - Zebrafish Xenograft Model for Predicting Cisplatin Efficacy in Muscle-Invasive Bladder Cancer.
Yusuke Sugino; Xin Bao; Sho Sekito; Shiori Miyachi; Takumi Kageyama; Takeshi Sasaki; Kouhei Nishikawa; Toshio Tanaka; Manabu Kato; Yasuhito Shimada; Keishi Takano; Raku Son; Liqing Zang; Kenji Nakayama; Masatoshi Watanabe; Yasuhiro Murakawa; Takahiro Inoue
(2025) Cancer science 2025 Dec 10.1111/cas.70217 [41059675] - Microtubule architecture connects AMOT stability to YAP/TAZ mechanotransduction and Hippo signalling.
Giada Vanni; Anna Citron; Ambela Suli; Paolo Contessotto; Robin Caire; Alessandro Gandin; Giovanna Mantovan; Francesca Zanconato; Giovanna Brusatin; Michele Di Palma; Elisa Peirano; Lisa Sofia Pozzer; Carlo Albanese; Roberto A Steiner; Michelangelo Cordenonsi; Tito Panciera; Stefano Piccolo
(2025) Nature cell biology 2025 Oct 10.1038/s41556-025-01773-z [41034521] - Periodic fasting induced reconstitution of metabolic flexibility improves albuminuria in patients with type 2 diabetes.
Alba Sulaj 1, Phong B H Nguyen 2, Gernot Poschet 3, Elisabeth Kliemank 4, Thomas Fleming 4, Lea Henke 4, Wiebke Neibig 4, Stefan Kopf 5, Rüdiger Hell 3, Valter D Longo 6, Stephan Herzig 7, Peter P Nawroth 8, Michael P Menden 9, Julia Szendroedi 8
(2025) Molecular metabolism 2025 Dec 10.1016/j.molmet.2025.102257 [41005725] - Mismatch Repair as a Dynamic and Clinically Actionable Vulnerability in Cancer.
Eleonora Piumatti; Pietro Paolo Vitiello; Vito Amodio; Alberto Bardelli; Giovanni Germano
(2025) Cancer research 2025 Nov 14 10.1158/0008-5472.CAN-25-2255 [40991396] - Author Correction: Fasting mimicking diet cycles versus a Mediterranean diet and cardiometabolic risk in overweight and obese hypertensive subjects: a randomized clinical trial.
Amrendra Mishra; Maura Fanti; Xinzhou Ge; Don Vaughn; Sebastian Brandhorst; Min Wei; Kurt M Hong; Matteo Pellegrini; Hanno Pijl; Mark C Houston; Valter D Longo
(2025) npj metabolic health and disease 2025 Sep 23 10.1038/s44324-025-00084-z [40987812] - Mammalian H4K16ac regulates the spatiotemporal order of genome replication rather than gene expression.
Marta Milan; Valeria Runfola; Manthan Patel; Lucia Falbo; Roberta Noberini; Chiara Soriani; Simona Rodighiero; Tiziana Bonaldi; Vincenzo Costanzo; Madapura M Pradeepa; Paola Scaffidi
(2025) Nucleic acids research 2025 Sep 23 10.1093/nar/gkaf916 [40985775] - Telomeric DNA damage response mediates neurotoxicity of Aβ42 oligomers in Alzheimer's disease.
Sara Sepe; Federica Rey; Alexandra Mancheno-Ferris; Alessandra Bigi; Giulia Fani; Devid Damiani; Matteo Cabrini; Eugenia Marinelli; Julio Aguado; Liliana Contu; Alessia di Lillo; Sara Boggio; Sara Tavella; Ilaria Rosso; Stefano Gustincich; Fabrizio Chiti; Fabrizio d'Adda di Fagagna
(2025) The EMBO journal 2025 Nov 10.1038/s44318-025-00521-1 [40976786] - KRAS G12C Inhibition in Solid Tumors: Biological Breakthroughs, Clinical Evidence, and Open Challenges.
Pietro Paolo Vitiello; Anna Amela Valsecchi; Eleonora Duregon; Paola Francia Di Celle; Paola Cassoni; Mauro Papotti; Alberto Bardelli; Massimo Di Maio
(2025) Cancers 2025 Aug 27 10.3390/cancers17172803 [40940900] - Author Correction: Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.
Kate Lawrenson; Siddhartha Kar; Karen McCue?; Karoline Kuchenbaeker; Kyriaki Michailidou; Jonathan Tyrer; Jonathan Beesley; Susan J Ramus; Qiyuan Li; Melissa K Delgado; Janet M Lee; Kristiina Aittomäki; Irene L Andrulis; Hoda Anton-Culver; Volker Arndt; Banu K Arun; Brita Arver; Elisa V Bandera; Monica Barile; Rosa B Barkardottir; Daniel Barrowdale; Matthias W Beckmann; Javier Benitez; Andrew Berchuck; Maria Bisogna; Line Bjorge; Carl Blomqvist; William Blot; Natalia Bogdanova; Anders Bojesen; Stig E Bojesen; Manjeet K Bolla; Bernardo Bonanni; Anne-Lise Børresen-Dale; Hiltrud Brauch; Paul Brennan; Hermann Brenner; Fiona Bruinsma; Joan Brunet; Shaik Ahmad Buhari; Barbara Burwinkel; Ralf Butzow; Saundra S Buys; Qiuyin Cai; Trinidad Caldes; Ian Campbell; Rikki Cannioto; Jenny Chang-Claude; Jocelyne Chiquette; Ji-Yeob Choi; Kathleen B M Claes; GEMO Study Collaborators; Linda S Cook; Angela Cox; Daniel W Cramer; Simon S Cross; Cezary Cybulski; Kamila Czene; Mary B Daly; Francesca Damiola; Agnieszka Dansonka-Mieszkowska; Hatef Darabi; Joe Dennis; Peter Devilee; Orland Diez; Jennifer A Doherty; Susan M Domchek; Cecilia M Dorfling; Thilo Dörk; Martine Dumont; Hans Ehrencrona; Bent Ejlertsen; Steve Ellis; EMBRACE; Christoph Engel; Eunjung Lee; D Gareth Evans; Peter A Fasching; Lidia Feliubadalo; Jonine Figueroa; Dieter Flesch-Janys; Olivia Fletcher; Henrik Flyger; Lenka Foretova; Florentia Fostira; William D Foulkes; Brooke L Fridley; Eitan Friedman; Debra Frost; Gaetana Gambino; Patricia A Ganz; Judy Garber; Montserrat García-Closas; Aleksandra Gentry-Maharaj; Maya Ghoussaini; Graham G Giles; Rosalind Glasspool; Andrew K Godwin; Mark S Goldberg; David E Goldgar; Anna González-Neira; Ellen L Goode; Marc T Goodman; Mark H Greene; Jacek Gronwald; Pascal Guénel; Christopher A Haiman; Per Hall; Emily Hallberg; Ute Hamann; Thomas V O Hansen; Patricia A Harrington; Mikael Hartman; Norhashimah Hassan; Sue Healey; Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON); Florian Heitz; Josef Herzog; Estrid Høgdall; Claus K Høgdall; Frans B L Hogervorst; Antoinette Hollestelle; John L Hopper; Peter J Hulick; Tomasz Huzarski; Evgeny N Imyanitov; KConFab? Investigators; Australian Ovarian Cancer Study Group; Claudine Isaacs; Hidemi Ito; Anna Jakubowska; Ramunas Janavicius; Allan Jensen; Esther M John; Nichola Johnson; Maria Kabisch; Daehee Kang; Miroslav Kapuscinski; Beth Y Karlan; Sofia Khan; Lambertus A Kiemeney; Susanne Kruger Kjaer; Julia A Knight; Irene Konstantopoulou; Veli-Matti Kosma; Vessela Kristensen; Jolanta Kupryjanczyk; Ava Kwong; Miguel de la Hoya; Yael Laitman; Diether Lambrechts; Nhu Le; Kim De Leeneer; Jenny Lester; Douglas A Levine; Jingmei Li; Annika Lindblom; Jirong Long; Artitaya Lophatananon; Jennifer T Loud; Karen Lu; Jan Lubinski; Arto Mannermaa; Siranoush Manoukian; Loic Le Marchand; Sara Margolin; Frederik Marme; Leon F A G Massuger; Keitaro Matsuo; Sylvie Mazoyer; Lesley McGuffog?; Catriona McLean?; Iain McNeish?; Alfons Meindl; Usha Menon; Arjen R Mensenkamp; Roger L Milne; Marco Montagna; Kirsten B Moysich; Kenneth Muir; Anna Marie Mulligan; Katherine L Nathanson; Roberta B Ness; Susan L Neuhausen; Heli Nevanlinna; Silje Nord; Robert L Nussbaum; Kunle Odunsi; Kenneth Offit; Edith Olah; Olufunmilayo I Olopade; Janet E Olson; Curtis Olswold; David O'Malley; Irene Orlow; Nick Orr; Ana Osorio; Sue Kyung Park; Celeste L Pearce; Tanja Pejovic; Paolo Peterlongo; Georg Pfeiler; Catherine M Phelan; Elizabeth M Poole; Katri Pylkäs; Paolo Radice; Johanna Rantala; Muhammad Usman Rashid; Gad Rennert; Valerie Rhenius; Kerstin Rhiem; Harvey A Risch; Gus Rodriguez; Mary Anne Rossing; Anja Rudolph; Helga B Salvesen; Suleeporn Sangrajrang; Elinor J Sawyer; Joellen M Schildkraut; Marjanka K Schmidt; Rita K Schmutzler; Thomas A Sellers; Caroline Seynaeve; Mitul Shah; Chen-Yang Shen; Xiao-Ou Shu; Weiva Sieh; Christian F Singer; Olga M Sinilnikova; Susan Slager; Honglin Song; Penny Soucy; Melissa C Southey; Marie Stenmark-Askmalm; Dominique Stoppa-Lyonnet; Christian Sutter; Anthony Swerdlow; Sandrine Tchatchou; Manuel R Teixeira; Soo H Teo; Kathryn L Terry; Mary Beth Terry; Mads Thomassen; Maria Grazia Tibiletti; Laima Tihomirova; Silvia Tognazzo; Amanda Ewart Toland; Ian Tomlinson; Diana Torres; Thérèse Truong; Chiu-Chen Tseng; Nadine Tung; Shelley S Tworoger; Celine Vachon; Ans M W van den Ouweland; Helena C van Doorn; Elizabeth J van Rensburg; Laura J Van't Veer; Adriaan Vanderstichele; Ignace Vergote; Joseph Vijai; Qin Wang; Shan Wang-Gohrke; Jeffrey N Weitzel; Nicolas Wentzensen; Alice S Whittemore; Hans Wildiers; Robert Winqvist; Anna H Wu; Drakoulis Yannoukakos; Sook-Yee Yoon; Jyh-Cherng Yu; Wei Zheng; Ying Zheng; Kum Kum Khanna; Jacques Simard; Alvaro N Monteiro; Juliet D French; Fergus J Couch; Matthew L Freedman; Douglas F Easton; Alison M Dunning; Paul D Pharoah; Stacey L Edwards; Georgia Chenevix-Trench; Antonis C Antoniou; Simon A Gayther
(2025) Nature communications 2025 Sep 08 10.1038/s41467-025-63507-x [40925936] - A blood-based DNA damage signature in patients with Parkinson's disease is associated with disease progression.
Daisy Sproviero; César Payán-Gómez; Chiara Milanese; Sander Barnhoorn; Shixiang Sun; Akos Gyenis; Domenico Delia; Tammaryn Lashley; Jan H J Hoeijmakers; Jan Vijg; Pier G Mastroberardino
(2025) Nature aging 2025 Sep 10.1038/s43587-025-00926-x [40913219] - Detecting Cancer Early with Ultrasensitive Multimodal Liquid Biopsy.
Giovanni Crisafulli; Nadia Saoudi Gonzalez; Giorgio Patelli; Alberto Bardelli
(2025) Cancer discovery 2025 Sep 04 10.1158/2159-8290.CD-25-1025 [40904099] - Cargoes move from cis to trans-Golgi compartments and concentrate in the TGN before exiting.
Marinella Pirozzi; Ilenia Agliarulo; Rosaria Di Martino; Vincenzo Manuel Marzullo; Micaela Quarto; Gabriele Turacchio; Galina V Beznoussenko; Domenico Russo; Alberto Luini; Alexander A Mironov; Seetharaman Parashuraman
(2025) EMBO reports 2025 Oct 10.1038/s44319-025-00548-9 [40903494] - Potential Involvement of Myostatin in Smooth Muscle Differentiation in Pleomorphic Leiomyosarcoma.
Hiroko Onagi; Raku Son; Akiko Oguchi; Kei Sano; Keita Sasa; Nobuhiko Hasegawa; Keisuke Akaike; Daisuke Kubota; Tatsuya Takagi; Takuo Hayashi; Muneaki Ishijima; Takashi Yao; Yoshiyuki Suehara; Yasuhiro Murakawa; Tsuyoshi Saito
(2025) International journal of molecular sciences 2025 Aug 08 10.3390/ijms26167676 [40868997] - Exploring the Relationship Between Insulin Resistance, Liver Health, and Restrictive Lung Diseases in Type 2 Diabetes.
Mani Roshan 1 2, Christian Mudrack 1, Alba Sulaj 1 2, Ekaterina von Rauchhaupt 1 2, Thomas Fleming 1 2, Lukas Schimpfle 1 2, Lukas Seebauer 1 2, Viktoria Flegka 1 2, Valter D Longo 3 4, Elisabeth Kliemank 1 2, Stephan Herzig 2 5 6, Anna Hohneck 1 2, Zoltan Kender 1 2, Julia Szendroedi 1 2 5 6, Stefan Kopf 1 2
(2025) Journal of personalized medicine 2025 Aug 01 10.3390/jpm15080340 [40863403] - Structural obstruction to full DNA replication in terminally differentiated skeletal muscle cells.
Sara Zribi; Gladio Joel Giannitelli; Laura Bernardini; Federica Censi; Serena Camerini; Lucia Bertuccini; Francesca Iosi; Emilia Giannella; Massimo Sanchez; Elisa Consoli; Andrea Casagrande; Alessandra Cenci; Giovanna Floridia; Antonio Novelli; Alessandro Giuliani; Vincenzo Costanzo; Marco Crescenzi; Deborah Pajalunga
(2025) EMBO reports 2025 Oct 10.1038/s44319-025-00554-x [40859015] - Combining BET inhibition with SMAC mimetics restricts tumor growth and triggers immune surveillance in preclinical cancer models.
Ksenija Slavic Obradovic; Florian Ebner; Artem V Artemov; Martina Miotto; Paula-Elena Traexler; Robin Jacob; Ha Pham Thi Thanh; Regina Ruzicka; Andreas Wernitznig; Ines Baumann; Daniel Gerlach; Maria-Antonietta Impagnatiello; Salvatore Siena; Mary Murphy; Reniqua House; Ulrich Reiser; Valeria Santoro; Johannes Popow; Sebastian Carotta; Anke Baum; Jesse Lipp; Alberto Bardelli; Ulrike Tontsch-Grunt; Mariangela Russo; Martin Aichinger
(2025) Cell reports. Medicine 2025 Sep 16 10.1016/j.xcrm.2025.102313 [40858106] - Prolonging lung cancer response to EGFR inhibition by targeting the selective advantage of resistant cells.
Lisa Brunet; David Alexandre; Jiyoung Lee; Maria Del Mar Blanquer-Rosselló; David Bracquemond; Alexis Guernet; Houssein Chhouri; Mathilde Goupil; Zoulika Kherrouche; Arnaud Arabo; Maicol Mancini; Dorthe Cartier; Shen Yao; David Godefroy; Julie Dehedin; Jian-Rong Li; Céline Duparc; Philippe Jamme; Audrey Vinchent; Caroline Bérard; David Tulasne; Sabrina Arena; Alberto Bardelli; Chao Cheng; Byoung Chul Cho; Olivier Wurtz; Cédric Coulouarn; Antonio Maraver; Stuart A Aaronson; Alexis B Cortot; Youssef Anouar; Luca Grumolato
(2025) Nature communications 2025 Aug 22 10.1038/s41467-025-61788-w [40846697] - Quantifying Nuclear Shape Fluctuations During Early Mitosis.
Viola Introini; Giancarlo Porcella; Gururaj Rao Kidiyoor; Pietro Cicuta; Marco Cosentino Lagomarsino
(2025) Methods in molecular biology (Clifton, N.J.) 2025 10.1007/978-1-0716-4714-1_10 [40833572] - Role of immunosuppressive JNK pathway in the tumor microenvironment among TNBC subtypes in IBCSG trial 22-00.
Andrea Joaquin Garcia; Takashi Semba; Mattia Rediti; Daniel J McGrail?; Xuemei Xie; Xiaoping Wang; Dileep R Rampa; David Venet; Laurence Buisseret; Samira Majjaj; Roswitha Kammler; Marco Colleoni; Sherene Loi; Giuseppe Viale; Meredith M Regan; Françoise Rothé; Christos Sotiriou; Naoto T Ueno
(2025) iScience 2025 Aug 15 10.1016/j.isci.2025.112964 [40822334] - Genotype-phenotype correlations in biallelic carriers of FANCM protein truncating variants: A systematic literature review.
Gisella Figlioli; Amandine Billaud; Paolo Peterlongo
(2025) Mutation research. Reviews in mutation research 2025 10.1016/j.mrrev.2025.108559 [40818381] - Stem-like and effector peripheral helper T cells comprise distinct subsets in rheumatoid arthritis.
Yuki Masuo; Akinori Murakami; Rinko Akamine; Osamu Iri; Shunsuke Uno; Koichi Murata; Kohei Nishitani; Hiromu Ito; Ryu Watanabe; Takayuki Fujii; Takeshi Iwasaki; Shinichiro Nakamura; Shinichi Kuriyama; Yugo Morita; Yasuhiro Murakawa; Chikashi Terao; Yukinori Okada; Motomu Hashimoto; Shuichi Matsuda; Hideki Ueno; Hiroyuki Yoshitomi
(2025) Science immunology 2025 Aug 15 10.1126/sciimmunol.adt3955 [40815671] - HGF Overexpression in Mesenchymal Stromal Cell-Based Cell Sheets Enhances Autophagy-Dependent Cytoprotection and Proliferation to Guard the Epicardial Mesothelium.
Konstantin Dergilev; Irina Beloglazova; Zoya Tsokolaeva; Ekaterina Azimova; Aleria Dolgodvorova; Yulia Goltseva; Maria Boldyreva; Mikhail Menshikov; Dmitry Penkov; Yelena Parfyonova
(2025) International journal of molecular sciences 2025 Jul 28 10.3390/ijms26157298 [40806435] - Structure of the Secretory Compartments in Goblet Cells in the Colon and Small Intestine.
Alexander A Mironov; Irina S Sesorova; Pavel S Vavilov; Roberto Longoni; Paola Briata; Roberto Gherzi; Galina V Beznoussenko
(2025) Cells 2025 Jul 31 10.3390/cells14151185 [40801617] - Identification of new selective CD36 inhibitors to potentiate HER2-targeted therapy in HER2-positive breast cancer.
Lorenzo Castagnoli; Francesco Bonì; Martina Bigliardi; Paolo Toneguzzo; Paola A Corsetto; Giorgia Galasso; Alma Franceschini; Paolo Cocomazzi; Viola Regondi; Cristian Capuzzoni; Angela M Rizzo; Francesca Ligorio; Claudio Vernieri; Pierfausto Seneci; Daniela Arosio; Elda Tagliabue; Eloise Mastrangelo; Mario Milani; Serenella M Pupa
(2025) Scientific reports 2025 Aug 06 10.1038/s41598-025-14639-z [40770043] - Human CD4+ T cells regulate peripheral immune responses in rheumatoid arthritis via insulin-like growth factor-like family member 2.
Akinori Murakami; Rinko Akamine; Shiro Tanaka; Koichi Murata; Kohei Nishitani; Hiromu Ito; Ryu Watanabe; Takayuki Fujii; Takeshi Iwasaki; Yuki Masuo; Osamu Iri; Shinichiro Nakamura; Shinichi Kuriyama; Yugo Morita; Yasuhiro Murakawa; Chikashi Terao; Yukinori Okada; Motomu Hashimoto; Shuichi Matsuda; Hideki Ueno; Hiroyuki Yoshitomi
(2025) Science immunology 2025 Aug 10.1126/sciimmunol.adr3838 [40749037] - Correction: Preoperative ctDNA retains prognostic relevance beyond postoperative assessment in stage II-III colon cancer.
Giulia Chisari; Emanuele Martorana; Sofia Paola Lombardo; Gabriele Raciti; Raffaella Giuffrida; Alberto Bardelli; Domenico Scionti; Marzia Mare; Carolina Picardo; Enrica Deiana; Lorenzo Memeo; Cristina Colarossi; Giovanni Crisafulli; Stefano Forte
(2025) Clinical and experimental medicine 2025 Jul 29 10.1007/s10238-025-01824-7 [40728693] - Patient-Derived Explants of Osteoarthritic Synovium as Ex Vivo Model for Preclinical Research.
Claudia D'Oria; Gilberto Cincinelli; Ramona Bason; Federica Pisati; Francesca Simoncello; Isabella Scotti; Laura Giudice; Ilaria Suardi; Paolo Ferrua; Chiara Fossati; Pietro Simone Randelli; Roberto Caporali; Massimiliano Pagani; Francesca Ingegnoli
(2025) International journal of molecular sciences 2025 Jul 11 10.3390/ijms26146665 [40724912] - RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics.
Grégoire Lemahieu; Paulina Moreno-Layseca; Tobias Hub; Carlo Bevilacqua; Manuel Gómez-González; Federica Pennarola; Federico Colombo; Andrew E Massey; Leonardo Barzaghi; Andrea Palamidessi; Leon-Luca Homagk; Samuel F H Barnett; Alexander X Cartagena-Rivera; Christine Selhuber-Unkel; Robert Prevedel; Xavier Trepat; Joachim P Spatz; Johanna Ivaska; Giorgio Scita; Elisabetta Ada Cavalcanti-Adam
(2025) Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep 10.1002/advs.202503569 [40712149] - Gene expression profiling in a retrospective real-world cohort of breast cancer brain metastases and paired primary tumors identifies biological changes with potential therapeutic implications.
G Griguolo; M V Dieci; S Fineberg; C Pinato; M Bottosso; L Bauchet; F Miglietta; J Jacob; V Rigau; M C Guarascio; F Zanconato; F Schiavi; M Fassan; A P Dei Tos; W Jacot; S Piccolo; A Darlix; V Guarneri
(2025) ESMO open 2025 Aug 10.1016/j.esmoop.2025.105507 [40706225] - The 50-nm Free Vesicles Visible in Saccharomyces cerevisiae Are Not COPII-Dependent.
Alexander A Mironov; Aurora Fusella; Galina V Beznoussenko
(2025) Current issues in molecular biology 2025 May 07 10.3390/cimb47050336 [40699735] - Aggressive B cell lymphomas retain ATR-dependent determinants of T cell exclusion from the germinal center dark zone.
Valeria Cancila; Giorgio Bertolazzi; Allison Sy Chan; Giovanni Medico; Giulia Bastianello; Gaia Morello; Daniel Paysan; Clemence Lai; Liang Hong; Girija Shenoy; Patrick W Jaynes; Giovanna Schiavoni; Fabrizio Mattei; Silvia Piconese; Maria V Revuelta; Francesco Noto; Luca Businaro; Adele De Ninno; Ilenia Cammarata; Fabio Pagni; Saradha Venkatachalapathy; Sabina Sangaletti; Arianna Di Napoli; Giada Cicio; Davide Vacca; Silvia Lonardi; Luisa Lorenzi; Andrés Jm Ferreri; Beatrice Belmonte; Min Liu; Manikandan Lakshmanan; Michelle Sn Ong; Biyan Zhang; Tingyi See; Kong-Peng Lam; Gabriele Varano; Mario P Colombo; Silvio Bicciato; Giorgio Inghirami; Leandro Cerchietti; Maurilio Ponzoni; Roberta Zappasodi; Evelyn Metzger; Joseph Beechem; Fabio Facchetti; Marco Foiani; Stefano Casola; Anand D Jeyasekharan; Claudio Tripodo
(2025) The Journal of clinical investigation 2025 Sep 16 10.1172/JCI187371 [40674145] - Sirtuins and their role in ovarian aging-related fibrosis predisposing to ovarian cancer.
Arkadiusz Grzeczka; Agnieszka Skowronska; Sara Sepe; Mariusz T Skowronski; Pawe? Kordowitzki
(2025) npj aging 2025 Jul 15 10.1038/s41514-025-00256-7 [40664665] - TRF1 relies on fork reversal to prevent fragility at human telomeres.
Mélina Vaurs; Eloïse Claude; Elia Zanella; Joana Rodrigues; Joe Nassour; Jan Karlseder; Claus M Azzalin; Ylli Doksani; Anabelle Decottignies
(2025) Nature communications 2025 Jul 11 10.1038/s41467-025-61828-5 [40645989] - Biomarkers of psychological stress are associated with increased susceptibility to the development of breast and prostate cancer in BRCA1/2 mutation carriers.
R L Flaherty; M Falcinelli; A R Hesketh; B A Patel; E Bancroft; E Page; R Eeles; IMPACT Study Steering Committee and Collaborators; M S Flint
(2025) British journal of cancer 2025 Sep 10.1038/s41416-025-03085-3 [40603570] - Preoperative ctDNA retains prognostic relevance beyond postoperative assessment in stage II-III colon cancer.
Giulia Chisari; Emanuele Martorana; Sofia Paola Lombardo; Gabriele Raciti; Raffaella Giuffrida; Alberto Bardelli; Domenico Scionti; Marzia Mare; Carolina Picardo; Enrica Deiana; Lorenzo Memeo; Cristina Colarossi; Giovanni Crisafulli; Stefano Forte
(2025) Clinical and experimental medicine 2025 Jun 30 10.1007/s10238-025-01762-4 [40586891] - Immunocytokines in cancer treatment: A systematic review.
Stefano Agliardi; Chiara Veronese; Ferdinando Panzeri; Simonetta Palazzini; Greta Guarnieri; Stefano Loiacono; Vanessa Martinelli; Anna Maria Potenza; Emanuele Sbraga; Eleonora Rissotto; Elvira Inglese; Federica Tosi; Federica Villa; Giorgio Patelli; Letizia Monti; Arianna Pani; Romano Danesi; Diego Fornasari; Salvatore Siena; Andrea Sartore-Bianchi
(2025) Cancer treatment reviews 2025 Sep 10.1016/j.ctrv.2025.102978 [40554920] - Angiopoietin-like protein 2 mediates vasculopathy-driven fibrogenesis in a mouse model of systemic sclerosis.
Dyuti Saha; Ravi Kiran Annadorai; Sujaya Thannimangalath; Neha P Shroff; Sunny Kataria; Binita Dam; Abhik Dutta; Akshay Hegde; Ankita Hiwale; Venkatesh Ravula; Shagnik Saha; Lekshmi Minikumari Rahulan; Neha Nigam; Neha Singh; Vikas Agarwal; Praveen K Vemula; Colin Jamora
(2025) The Journal of clinical investigation 2025 Aug 01 10.1172/JCI177123 [40540411] - USP37 prevents premature disassembly of stressed replisomes by TRAIP.
Olga V Kochenova; Giuseppina D'Alessandro; Domenic Pilger; Ernst Schmid; Sean L Richards; Marcos Rios Garcia; Satpal S Jhujh; Andrea Voigt; Vipul Gupta; Christopher J Carnie; R Alex Wu; Nadia Gueorguieva; Simon Lam; Grant S Stewart; Johannes C Walter; Stephen P Jackson
(2025) Nature communications 2025 Jun 18 10.1038/s41467-025-60139-z [40533495] - Nuclear deformability increases PARPi sensitivity in BRCA1-deficient cells by increasing microtubule-dependent DNA break mobility.
Elena Faustini; Angela Dello Stritto; Andrea Panza; Ylli Doksani; Francisca Lottersberger
(2025) Nature communications 2025 Jun 17 10.1038/s41467-025-60756-8 [40527886] - Case Report WIN-MTB-2023001 WIN International Molecular Tumor Board A 62-year-old male with metastatic colorectal cancer with 5 prior lines of treatment.
Alberto Hernando-Calvo; Razelle Kurzrock; Nadia Saoudi Gonzalez; Shai Magidi; Catherine Bresson; Fanny Wunder; Giulia Pretelli; Agatha Martin Casado; Wafik S El-Deiry
(2025) Oncotarget 2025 Jun 17 10.18632/oncotarget.28744 [40526090] - Cisplatin and temozolomide combinatorial treatment triggers hypermutability and immune surveillance in experimental cancer models.
Pietro Paolo Vitiello; Benoit Rousseau; Rosaria Chilà; Paolo Battuello; Vito Amodio; Vittorio Battaglieri; Gaia Grasso; Sharon Scardellato; Achille Anselmo; Francesca Clemente; Giuseppe Rospo; Simona Lamba; Alice Bartolini; Federica Pisati; Claudio Tripodo; Noemi Congiusta; Mariangela Russo; Giovanni Crisafulli; Federica Di Nicolantonio; Giovanni Germano; Luis A Diaz; Alberto Bardelli
(2025) Cancer cell 2025 Jul 14 10.1016/j.ccell.2025.05.014 [40513578] - Induction of a mismatch repair deficient genotype by tailored chemical mutagenesis in experimental models of cancer.
Benoit Rousseau; Mitesh Patel; Oliver Artz; Georgios Vlachos; Shrey Patel; Omar Hayatt; Guillem Argilés; Michael B Foote; Lingqi Luo; Rachna Shah; Shub Mehta; Karthik Rangavajhula; Caitlin M Stewart; Drew Gerber; Rohini Bhattacharya; Dennis Stephens; David Mieles; Violaine Randrian; Somer Abdelfattah; Lin Zhang; Nathalie Membreno-Berganza; Michelle F Lamendola-Essel; Florence Piastra-Facon; Joana Vidal; Paul Johannet; Steve Lu; James R White; Steven B Maron; Afsar Barlas; Caroline M Weipert; Eric Rosiek; Taotao Zhang; Bing He; Sebastien Monette; Rui Qu; Deborah Fidele; Sydney Bowker; Alec Kahn; Pietro Paolo Vitiello; Giovanni Germano; Alberto Bardelli; Rajarsi Mandal; Xiaoxiao Ma; Tim A Chan; Sydney Lu; Andrea Cercek; Omar Abdel-Wahab; Elisa de Stanchina; Neil H Segal; Luis A Diaz
(2025) Cancer cell 2025 Jul 14 10.1016/j.ccell.2025.05.010 [40513573] - Real-World Outcomes of Molecular Tumor Board Treatment Recommendations.
Federico Nichetti; Marta Brambilla; Matteo Duca; Alberta Piccolo; Daniela Miliziano; Chiara Cavalli; Francesca Marra; Paolo Ambrosini; Caterina Zanella; Claudio Vernieri; Daniele Lorenzini; Elena Colombo; Silvia Damian; Paolo Baili; Claudia Proto; Adele Busico; Elena Conca; Iolanda Capone; Siranoush Manoukian; Elena Tamborini; Federica Perrone; Monica Niger; Andrea Vingiani; Luca Agnelli; Filippo de Braud; Giancarlo Pruneri
(2025) JCO precision oncology 2025 Jun 10.1200/PO-24-00387 [40499091] - Gut Microbiota Modulation through Akkermansia spp. Supplementation Increases CAR T-cell Potency.
Laura Marcos-Kovandzic; Michele Avagliano; Myriam Ben Khelil; Janesa Srikanthan; Rim Abdallah; Valentina Petrocelli; Jessica Rengassamy; Alexia Alfaro; Mathilde Bied; Marine Fidelle; Gladys Ferrere; Romain Daillère; Ahmadreza Arbab; Roula Amine-Hneineh; Arnaud Pages; Peggy Dartigues; Pierre Ly; Sylvain Simon; Sylvère Durand; Adrian Gottschlich; Florent Ginhoux; Camille Blériot; Peng Liu; Liwei Zhao; Laura Creusot; Nathalie Rolhion; Lisa Derosa; Guido Kroemer; Laurie Menger; Sebastian Kobold; Cristina Castilla-Llorente; Harry Sokol; Stefano Casola; Edoardo Pasolli; Laurence Zitvogel; Camille Bigenwald
(2025) Cancer discovery 2025 Sep 04 10.1158/2159-8290.CD-24-1230 [40498998] - Correction: CD36 enrichment in HER2-positive mesenchymal stem cells drives therapy refractoriness in breast cancer.
Lorenzo Castagnoli; Alma Franceschini; Valeria Cancila; Matteo Dugo; Martina Bigliardi; Claudia Chiodoni; Paolo Toneguzzo; Viola Regondi; Paola A Corsetto; Filippo Pietrantonio; Serena Mazzucchelli; Fabio Corsi; Antonino Belfiore; Andrea Vingiani; Giancarlo Pruneri; Francesca Ligorio; Mario P Colombo; Elda Tagliabue; Claudio Tripodo; Claudio Vernieri; Tiziana Triulzi; Serenella M Pupa
(2025) Journal of experimental & clinical cancer research : CR 2025 May 30 10.1186/s13046-025-03426-3 [40442724] - DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue.
Stefania Modafferi; Stefania Farina; Francesca Esposito; Ornella Brandi; Michela Di Salvio; Ilaria Della Valle; Sara D'Uva; Eveljn Scarian; Giada Cicio; Adelaide Riccardi; Federica Pisati; Anna Garbelli; Tiziana Santini; Orietta Pansarasa; Mariangela Morlando; Nadia D'Ambrosi; Mauro Cozzolino; Gianluca Cestra; Fabrizio d'Adda di Fagagna; Ubaldo Gioia; Sofia Francia
(2025) Cell death and differentiation 2025 Dec 10.1038/s41418-025-01530-7 [40437235] - Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4.
Elena Maspero; Anna Cappa; Janine Weber; Paolo Trifirò; Raffaella Amici; Agostino Bruno; Giovanni Fagà; Valentina Cecatiello; Raimondo Fattori; Brian Leuzzi; Vincenzo Taibi; Giuseppe Meroni; Maurizio Pasi; Alessia Romussi; Luca Sartori; Manuela Villa; Stefania Vultaggio; Marco Cirò; Paolo Soffientini; Lierin Lombardo; Shakti Dahe; Angela Bachi; Mario Varasi; Mario Rossi; Sebastiano Pasqualato; Ciro Mercurio; Simona Polo
(2025) Communications chemistry 2025 May 28 10.1038/s42004-025-01557-4 [40437006] - TIMP1 Overexpression in Ovarian Cancer Spheroids: Implications for Prognosis, Resistance, and Metastatic Potential.
Andrea Jemma; Alessandra Ardizzoia; Chiara Villa; Sara Bonomo; Mario Mauri; Carla Reale; Concetta Ambrosino; Massimiliano Cadamuro; Marialuisa Lavitrano; Donatella Conconi
(2025) Cancers 2025 May 09 10.3390/cancers17101605 [40427104] - Metabolic traits shape responses to LSD1-directed therapy in glioblastoma tumor-initiating cells.
Giulia Marotta; Daniela Osti; Elena Zaccheroni; Brunella Costanza; Stefania Faletti; Adriana Marinaro; Cristina Richichi; Deborah Mesa; Simona Rodighiero; Chiara Soriani; Enrica Migliaccio; Federica Ruscitto; Chiara Priami; Sara Sigismund; Francesco Manetti; Dario Polli; Galina V Beznusenko; Mara-Camelia Rusu; Francesco Favero; Davide Corà; Domenico A Silvestris; Angela Gallo; Valentina Gambino; Fabio Alfieri; Sara Gandini; Matthias J Schmitt; Gaetano Gargiulo; Roberta Noberini; Tiziana Bonaldi; Giuliana Pelicci
(2025) Science advances 2025 May 23 10.1126/sciadv.adt2724 [40408499] - TRPM8 levels determine tumor vulnerability to channel agonists.
Alessandro Alaimo; Francesco Giuseppe Carbone; Kristi Buzo; Nicole Annesi; Sacha Genovesi; Annalisa Lorenzato; Karen Widmann; Michela Libergoli; Elisa Marmocchi; Giovanni Bertalot; Alberto Brolese; Mauro Giulio Papotti; Luca Molinaro; Orazio Caffo; Mattia Barbareschi; Alberto Bardelli; Alessandro Romanel; Sabrina Arena; Andrea Lunardi
(2025) Molecular oncology 2025 Oct 10.1002/1878-0261.70049 [40405392] - B-cell Receptor Silencing Reveals the Origin and Dependencies of High-Grade B-cell Lymphomas with MYC and BCL2 Rearrangements.
Gabriele Varano; Silvia Lonardi; Paola Sindaco; Ilaria Pietrini; Gaia Morello; Piera Balzarini; Filippo Vit; Hadas Neuman; Giorgio Bertolazzi; Silvia Brambillasca; Nicara C Parr; Marco Chiarini; Silvia Bellesi; Elena Maiolo; Sabrina Giampaolo; Federica Mainoldi; Viveka Selvarasa; Hiroshi Arima; Vilma Pellegrini; Chiara Pagani; Mattia Bugatti; Cecilia Ranise; Tommaso M Taddei; Takashi Sonoki; Hajdica Thanasi; Elena Morlacchi; Daniel Segura-Garzon; Emma Albertini; Rosa Daffini; Anojan Sivacegaram; Henry Yang; Ying Li; Valeria Cancila; Giada Cicio; Michela Robusto; Brian Leuzzi; Adrian Andronache; Paolo Trifiro; Mirko Riboni; Simone P Minardi; Raoul J P Bonnal; Cristina Lopez Gonzalez; Euplio Visco; Pasquale Capaccio; Sara Torretta; Lorenzo Pignataro; Camillo Almici; Mario Varasi; Luigi M Larocca; Reiner Siebert; Brunangelo Falini; Andres J M Ferreri; Alessandra Tucci; Daniele Lorenzini; Antonello D Cabras; Giancarlo Pruneri; Arianna Di Napoli; Marco Ungari; Marco Pizzi; Stefan Hohaus; Ciro Mercurio; Joo Y Song; Wing C Chan; Luisa Lorenzi; Riccardo Bomben; Maurilio Ponzoni; Ramit Mehr; Claudio Tripodo; Fabio Facchetti; Stefano Casola
(2025) Blood cancer discovery 2025 Jul 01 10.1158/2643-3230.BCD-25-0099 [40402557] - Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer.
Elena Grassi; Valentina Vurchio; George D Cresswell; Irene Catalano; Barbara Lupo; Francesco Sassi; Francesco Galimi; Sofia Borgato; Martina Ferri; Marco Viviani; Simone Pompei; Gianvito Urgese; Bingjie Chen; Eugenia R Zanella; Francesca Cottino; Mariangela Russo; Gianluca Mauri; Filippo Pietrantonio; Maria Giulia Zampino; Luca Lazzari; Silvia Marsoni; Alberto Bardelli; Marco Cosentino Lagomarsino; Andrea Sottoriva; Livio Trusolino; Andrea Bertotti
(2025) Science translational medicine 2025 May 21 10.1126/scitranslmed.ado1641 [40397712] - A Novel Cognitive Frailty Index for Geriatric Mice.
Serena Marcozzi; Giorgia Bigossi; Maria Elisa Giuliani; Giovanni Lai; Beatrice Bartozzi; Marta Balietti; Tiziana Casoli; Fiorenza Orlando; Andrea Amoroso; Robertina Giacconi; Maurizio Cardelli; Francesco Piacenza; Fabrizia Lattanzio; Fabiola Olivieri; Peter L J de Keizer; Fabrizio d'Adda di Fagagna; Marco Malavolta
(2025) Aging cell 2025 Jul 10.1111/acel.70056 [40395103] - Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome.
Sara Tavella; Alessia di Lillo; Anastasia Conti; Fabio Iannelli; Alexandra Mancheno-Ferris; Valentina Matti; Raffaella Di Micco; Fabrizio d'Adda di Fagagna
(2025) DNA repair 2025 May 10.1016/j.dnarep.2025.103840 [40319546] - Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations.
Michelangelo Marasco; Dinesh Kumar; Santiago Garcia Borrego; Tessa Seale; Giulia Maddalena; Riccardo Mezzadra; Kylie Belanger; Soren Cole; Brayan Perez; Wei Luan; Radha Mukherjee; Ilinca Aricescu; Vladimir Markov; Yuxin Zhu; Sabrina Arena; Alberto Bardelli; Elisa de Stanchina; Scott W Lowe; Richard A Burkhart; Jacquelyn W Zimmerman; Rona Yaeger; Scott E Kopetz; Neal Rosen; Sandra Misale
(2025) Cancer discovery 2025 Jul 03 10.1158/2159-8290.CD-24-0614 [40294008] - Reactive Bcl2-positive germinal centres in paediatric tonsils: expanding the spectrum of lymphoma mimickers in children and adolescents.
Marco Pizzi; Luisa Lorenzi; Federico Scarmozzino; Emma Albertini; Piera Balzarini; Marta Sbaraglia; Luisa Santoro; Mariella Chiudinelli; Lara Mussolin; Elisa Carraro; Cesare Cutrone; Stefano Casola; Vilma Pellegrini; Silvia Nalio; Laura Bonaldi; Marta Pillon; Angelo Paolo Dei Tos
(2025) Histopathology 2025 Jul 10.1111/his.15460 [40289261] - Downregulation of rRNA synthesis by BCL-2 induces chemoresistance in diffuse large B cell lymphoma.
Alessandra Rossi; Saveria Mazzara; Dorotea Salemi; Simone Zanetti; Maria Rosaria Sapienza; Stefania Orecchioni; Giovanna Talarico; Paolo Falvo; Alessandro Davini; Claudio Ceccarelli; Giovanna Motta; Federica Melle; Valentina Tabanelli; Claudio Agostinelli; Davide Trerè; Marianna Penzo; Chiara Corsini; Elena Baiardi; Angelica Calleri; Umberto Vitolo; Francesco Bertolini; Pier Luigi Zinzani; Roberto Chiarle; Corrado Tarella; Stefano Pileri; Enrico Derenzini
(2025) iScience 2025 May 16 10.1016/j.isci.2025.112333 [40276769] - Clinical utility and future perspectives of liquid biopsy in colorectal cancer.
Giorgio Patelli; Luca Lazzari; Giovanni Crisafulli; Andrea Sartore-Bianchi; Alberto Bardelli; Salvatore Siena; Silvia Marsoni
(2025) Communications medicine 2025 Apr 24 10.1038/s43856-025-00852-4 [40275061] - From Therapy to Cancer Prevention Using HRD Testing on Patients with High-grade Ovarian Cancer.
Maria Grazia Tibiletti; Ileana Carnevali; Sofia Facchi; Valeria Pensotti; Giorgio Formenti; Nora Sahnane; Laura Libera; Susanna Ronchi; Sara Volorio; Marco Alessandro Pierotti; Stefano La Rosa; Fausto Sessa
(2025) Cancer prevention research (Philadelphia, Pa.) 2025 Jul 01 10.1158/1940-6207.CAPR-24-0474 [40244633] - KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation.
Maximiliano Arce; Iza Erzar; Fan Yang; Neeharika Senthilkumar; Favour C Onyeogaziri; Dario Ronchi; Frida C Ahlstrand; Nora Noll; Roberta Lugano; Mark Richards; Elisa Scola; Monica Corada; Francesca Lazzaroni; Linda Meggiolaro; Jens Schuster; Niklas Dahl; Mika Niemelä; Behnam Rezai Jahromi; Anna Dimberg; Silvia Lanfraconi; Roberto Latini; Peetra U Magnusson
(2025) Cell reports 2025 May 27 10.1016/j.celrep.2025.115576 [40238631] - Combining spatial transcriptomics and ECM imaging in 3D for mapping cellular interactions in the tumor microenvironment.
Tancredi Massimo Pentimalli; Simon Schallenberg; Daniel León-Periñán; Ivano Legnini; Ilan Theurillat; Gwendolin Thomas; Anastasiya Boltengagen; Sonja Fritzsche; Jose Nimo; Lukas Ruff; Gabriel Dernbach; Philipp Jurmeister; Sarah Murphy; Mark T Gregory; Yan Liang; Michelangelo Cordenonsi; Stefano Piccolo; Fabian Coscia; Andrew Woehler; Nikos Karaiskos; Frederick Klauschen; Nikolaus Rajewsky
(2025) Cell systems 2025 May 21 10.1016/j.cels.2025.101261 [40220761] - Oxidative stress at telomeres triggers internal DNA loops, TRF1 dissociation, and TRF2-dependent R-loops.
Trang Thu Nguyen; Giulia Mazzucco; Eftychia Kyriacou; Thomas Lunardi; Leona Brandl; Wareed Ahmed; Ylli Doksani; Joachim Lingner
(2025) Nucleic acids research 2025 Apr 10 10.1093/nar/gkaf285 [40219969] - Zic3 enables bimodal regulation of tyrosine hydroxylase expression in olfactory bulb and midbrain-derived neurons.
Smitha Bhaskar; Jeevan Gowda; Akshay Hegde; Surya Chandra Rao Thumu; Shreetama Banerjee; Helen M Bellchambers; Narendrakumar Ramanan; Paloma Merchan Sala; Kenneth Campbell; Stephanie Ware; Jyothi Prasanna; Anujith Kumar
(2025) Cell death discovery 2025 Apr 11 10.1038/s41420-025-02448-2 [40216742] - A Phase Ia/b study of MEK1/2 inhibitor binimetinib with MET inhibitor crizotinib in patients with RAS mutant advanced colorectal cancer (MErCuRIC?).
Francesca Aroldi; Elena Elez; Thierry André; Geraldine Perkins; Hans Prenen; Vlad Popovici; Peter Gallagher; Jennifer Houlden; Linda Collins; Corran Roberts; Christian Rolfo; Federica Di Nicolantonio; Margaret Grayson; Ruth Boyd; Karolien Bettens; Jurgen Delfavero; Victoria Coyle; Mark Lawler; Hajrah Khawaja; Pierre Laurent-Puig; Manuel Salto-Tellez; Tim S Maughan; Josep Tabernero; Richard Adams; Robert Jones; Bryan T Hennessy; Alberto Bardelli; Marc Peeters; Mark R Middleton; Richard H Wilson; Sandra Van Schaeybroeck; MErCuRIC? Trial Consortium
(2025) BMC cancer 2025 Apr 10 10.1186/s12885-025-14068-1 [40211189] - Real-world effectiveness comparison of first-line palbociclib, ribociclib or abemaciclib plus endocrine therapy in advanced HR-positive/HER2-negative BC patients: results from the multicenter PALMARES-2 study.
L Provenzano; M V Dieci; G Curigliano; M Giuliano; A Botticelli; M Lambertini; G Rizzo; R Pedersini; M Sirico; N La Verde; A Gennari; A Zambelli; A Toss; M Piras; M Giordano; B Tagliaferri; D Generali; D Sartori; D Miliziano; A Menichetti; F Ligorio; C Zurlo; G Griguolo; P P Berton Giachetti; V Faso; C Corti; E Chiappe; S Scagnoli; S Pisegna; C Capasso; C De Angelis; G Arpino; C Criscitiello; V Guarneri; G Pruneri; L Mariani; C Vernieri; PALMARES-2 Study Group
(2025) Annals of oncology : official journal of the European Society for Medical Oncology 2025 Jul 10.1016/j.annonc.2025.03.023 [40204155] - Deconstructing destruction: A rapid route to proteasomal fate.
Elena Maspero; Simona Polo
(2025) Molecular cell 2025 Apr 03 10.1016/j.molcel.2025.03.011 [40185076] - TRF2 interaction with nuclear envelope is required for cell polarization and metastasis in triple negative breast cancer.
Eleonora Petti; Serena Di Vito; Roberto Dinami; Manuela Porru; Stefano Marchesi; Jeroen Lohuis; Pasquale Zizza; Sara Iachettini; Erica Salvati; Carmen D'Angelo; Angela Rizzo; Carmen Maresca; Flora Ascione; Anna Di Benedetto; Simonetta Buglioni; Andrea Sacconi; Paola Ostano; Qingsen Li; Antonella Stoppacciaro; Carlo Leonetti; Jacco van Rheenen; Paolo Maiuri; Giorgio Scita; Annamaria Biroccio
(2025) Cell death & disease 2025 Mar 30 10.1038/s41419-025-07415-4 [40159489] - Incoherent feedback from coupled amino acids and ribosome pools generates damped oscillations in growing E. coli.
Rossana Droghetti; Philippe Fuchs; Ilaria Iuliani; Valerio Firmano; Giorgio Tallarico; Ludovico Calabrese; Jacopo Grilli; Bianca Sclavi; Luca Ciandrini; Marco Cosentino Lagomarsino
(2025) Nature communications 2025 Mar 29 10.1038/s41467-025-57789-4 [40157904] - A phase Ia study of the MEK1/2 inhibitor PD-0325901 with the c-MET inhibitor crizotinib in patients with advanced solid cancers.
Peter Gallagher; Christian Rolfo; Elena Elez; Julien Taieb; Jennifer Houlden; Linda Collins; Corran Roberts; Thierry André; Mark Lawler; Federica Di Nicolantonio; Margaret Grayson; Ruth Boyd; Vlad Popovici; Alberto Bardelli; Robbie Carson; Hajrah Khawaja; Pierre Laurent-Puig; Manuel Salto-Tellez; Bryan T Hennessy; Tim S Maughan; Josep Tabernero; Richard Adams; Robert Jones; Marc Peeters; Mark R Middleton; Richard H Wilson; Sandra Van Schaeybroeck; MErCuRIC? Trial Consortium
(2025) BJC reports 2025 Mar 26 10.1038/s44276-025-00133-6 [40140597] - HMCES corrupts replication fork stability during base excision repair in homologous recombination-deficient cells.
María José Peña-Gómez; Yaiza Rodríguez-Martín; Marta Del Rio Oliva; Yodhara Wijesekara Hanthi; Sara Berrada; Raimundo Freire; Jean Yves Masson; José Carlos Reyes; Vincenzo Costanzo; Iván V Rosado
(2025) Science advances 2025 Mar 28 10.1126/sciadv.ads3227 [40138423] - Dietary Amino Acids and Risk of Stroke Subtypes: Results from 3 Large Prospective Cohort Studies.
Tammy Yn Tong; Yanping Li; Kathryn M Rexrode; Walter C Willett; Qi Sun; JoAnn? E Manson; Valter D Longo; Timothy J Key; Frank B Hu
(2025) The Journal of nutrition 2025 May 10.1016/j.tjnut.2025.03.026 [40127732] - Germline Whole-Exome Sequencing in Non-Smoker Lung Cancer Patients Reveals Pathogenic Variants in Lung Cancer Driver Genes.
Giovanni Carapezza; Simone Paolo Minardi; Sara Noci; Giulia Pintarelli; Susanna Zanutto; Matteo Incarbone; Davide Tosi; Tommaso Antonio Dragani; Francesca Colombo; Marco Alessandro Pierotti; Manuela Gariboldi
(2025) Genes, chromosomes & cancer 2025 Mar 10.1002/gcc.70040 [40119744] - lncreased risk of slippage upon disengagement of the mitotic checkpoint.
Alma Beatrix Stier; Paolo Bonaiuti; János Juhász; Fridolin Gross; Andrea Ciliberto
(2025) PLoS? computational biology 2025 Mar 10.1371/journal.pcbi.1012879 [40106474] - Vitamin B12 in Cell Plasticity and Repair.
Christina Fissoun; Marta Kovatcheva
(2025) DNA and cell biology 2025 May 10.1089/dna.2025.0037 [40106269] - DNA damage response regulator ATR licenses PINK1-mediated mitophagy.
Christian Marx; Xiaobing Qing; Yamin Gong; Joanna Kirkpatrick; Kanstantsin Siniuk; Galina V Beznoussenko; Gururaj Rao Kidiyoor; Murat Kirtay; Katrin Buder; Philipp Koch; Martin Westermann; Christopher Bruhn; Eric J Brown; Xingzhi Xu; Marco Foiani; Zhao-Qi Wang
(2025) Nucleic acids research 2025 Feb 27 10.1093/nar/gkaf178 [40105243] - Fibroblasts and hiPS-Derived Astrocytes From CoPAN? Patients Showed Different Levels of Iron Overload Correlated With Senescent Phenotype.
Anna Cozzi; Paolo Santambrogio; Andrea Stefano Moro; Alessio Pelagatti; Alicia Rubio; Chiara Balestrucci; Ivano Di Meo; Valeria Tiranti; Sonia Levi
(2025) Glia 2025 Jul 10.1002/glia.70017 [40105046] - Loss of CYLD promotes splenic marginal zone lymphoma.
Athanasios Pseftogas; Jessica Bordini; Silvia Heltai; Ferdinando Bonfiglio; Georgios Gavriilidis; Vasileios Vasileiou; Sofoklis Keisaris; Daniela Belloni; Caterina Taccetti; Pamela Ranghetti; Eleonora Perotta; Michela Frenquelli; Uday Aditya Sarkar; Elisa Albi; Francesca Martini; Emmanuela Sant'Antonio; Fabrizio Mavilia; Fotis Psomopoulos; Manasori Daibata; José Ángel Martínez Climent; George Mosialos; Davide Rossi; Alessandro Campanella; Lydia Scarfò; Kostas Stamatopoulos; Konstantinos Xanthopoulos; Paolo Ghia
(2025) HemaSphere? 2025 Mar 10.1002/hem3.70098 [40098895] - The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research.
Shaunak Deota; Julie S Pendergast; Ullas Kolthur-Seetharam; Karyn A Esser; Frédéric Gachon; Gad Asher; Charna Dibner; Salvador Aznar Benitah; Carolina Escobar; Deborah M Muoio; Eric Erquan Zhang; Gökhan S Hotam??l?gil; Joseph Bass; Joseph S Takahashi; Joshua D Rabinowitz; Katja A Lamia; Rafael de Cabo; Shingo Kajimura; Valter D Longo; Ying Xu; Mitchell A Lazar; Eric Verdin; Juleen R Zierath; Johan Auwerx; Daniel J Drucker; Satchidananda Panda
(2025) Nature metabolism 2025 Mar 10.1038/s42255-025-01237-6 [40097742] - A CPC-shelterin-BTR axis regulates mitotic telomere deprotection.
Diana Romero-Zamora; Samuel Rogers; Ronnie Ren Jie Low; Scott G Page; Blake J E Lane; Shunya Kosaka; Andrew B Robinson; Lucy French; Noa Lamm; Fuyuki Ishikawa; Makoto T Hayashi; Anthony J Cesare
(2025) Nature communications 2025 Mar 17 10.1038/s41467-025-57456-8 [40097392] - In the Loop: Unusual DNA Structures at Telomeric Repeats and Their Impact on Telomere Function.
Elia Zanella; Ylli Doksani
(2025) Cold Spring Harbor perspectives in biology 2025 Dec 01 10.1101/cshperspect.a041694 [40097153] - Overlap of high-risk individuals across family history, genetic & non-genetic breast cancer risk models: Analysis of 180,398 women from European & Asian ancestries.
Peh Joo Ho; Christine Kim Yan Loo; Meng Huang Goh; Mustapha Abubakar; Thomas U Ahearn; Irene L Andrulis; Natalia N Antonenkova; Kristan J Aronson; Annelie Augustinsson; Sabine Behrens; Clara Bodelon; Natalia V Bogdanova; Manjeet K Bolla; Kristen Brantley; Hermann Brenner; Helen Byers; Nicola J Camp; Jose E Castelao; Melissa H Cessna; Jenny Chang-Claude; Stephen J Chanock; Georgia Chenevix-Trench; Ji-Yeob Choi; Sarah V Colonna; Kamila Czene; Mary B Daly; Francoise Derouane; Thilo Dörk; A Heather Eliassen; Christoph Engel; Mikael Eriksson; D Gareth Evans; Olivia Fletcher; Lin Fritschi; Manuela Gago-Dominguez; Jeanine M Genkinger; Willemina R R Geurts-Giele; Gord Glendon; Per Hall; Ute Hamann; Cecilia Y S Ho; Weang-Kee Ho; Maartje J Hooning; Reiner Hoppe; Anthony Howell; Keith Humphreys; ABCTB Investigators; kConFab Investigators; SGBCC Investigators; MyBrCa? Investigators; Hidemi Ito; Motoki Iwasaki; Anna Jakubowska; Helena Jernström; Esther M John; Nichola Johnson; Daehee Kang; Sung-Won Kim; Cari M Kitahara; Yon-Dschun Ko; Peter Kraft; Ava Kwong; Diether Lambrechts; Susanna Larsson; Shuai Li; Annika Lindblom; Martha Linet; Jolanta Lissowska; Artitaya Lophatananon; Robert J MacInnis?; Arto Mannermaa; Siranoush Manoukian; Sara Margolin; Keitaro Matsuo; Kyriaki Michailidou; Roger L Milne; Nur Aishah Mohd Taib; Kenneth Muir; Rachel A Murphy; William G Newman; Katie M O'Brien; Nadia Obi; Olufunmilayo I Olopade; Mihalis I Panayiotidis; Sue K Park; Tjoung-Won Park-Simon; Alpa V Patel; Paolo Peterlongo; Dijana Plaseska-Karanfilska; Katri Pylkäs; Muhammad U Rashid; Gad Rennert; Juan Rodriguez; Emmanouil Saloustros; Dale P Sandler; Elinor J Sawyer; Christopher G Scott; Shamim Shahi; Xiao-Ou Shu; Katerina Shulman; Jacques Simard; Melissa C Southey; Jennifer Stone; Jack A Taylor; Soo-Hwang Teo; Lauren R Teras; Mary Beth Terry; Diana Torres; Celine M Vachon; Maxime Van Houdt; Jelle Verhoeven; Clarice R Weinberg; Alicja Wolk; Taiki Yamaji; Cheng Har Yip; Wei Zheng; Mikael Hartman; Jingmei Li
(2025) medRxiv : the preprint server for health sciences 2025 Mar 03 10.1101/2025.02.27.25323002 [40093266] - Biophysical and Molecular mechanisms that control active wetting and tissue fluidification in epithelial tissues.
Stefano Marchesi; Chiara Guidolin; Andrew E Massey; Gregoire Lemahieu; Zeno Lavagnino; Galina V Beznoussenko; Alexandre A Mironov; Brenda Green; Elisa Allievi; Emanuele Martini; Serena Magni; Andrea Ghisleni; Caterina Lomazzi; Andrea Francesco Benvenuto; Andreas Schertel; Dario Parazzoli; Paolo Maiuri; Sara Sigismund; Nils Gauthier; Ada E Cavalcanti-Adam; Alexander X Cartagena-Rivera; Fabio Giavazzi; Giorgio Scita; Andrea Disanza
(2025) Research square 2025 Mar 03 10.21203/rs.3.rs-6008502/v1 [40092432] - Enhancing yeast cell tracking with a time-symmetric deep learning approach.
Gergely Szabó; Paolo Bonaiuti; Andrea Ciliberto; András Horváth
(2025) NPJ systems biology and applications 2025 Mar 13 10.1038/s41540-024-00466-x [40082471] - Extraction of a stromal metastatic gene signature in breast cancer via spatial profiling.
Giorgio Bertolazzi; Valeria Cancila; Davide Vacca; Beatrice Belmonte; Daniele Lecis; Parsa Sirati Moghaddam; Arianna Di Napoli; Mario Paolo Colombo; Giancarlo Pruneri; Giannino Del Sal; Giorgio Scita; Matteo Fassan; Andrea Vecchione; Silvio Bicciato; Claudio Tripodo
(2025) Journal of experimental & clinical cancer research : CR 2025 Mar 08 10.1186/s13046-025-03353-3 [40065328] - Circulating blood biomarkers for minimal residual disease in hepatocellular carcinoma: A systematic review.
Edoardogregorio Galli; Giorgio Patelli; Federica Villa; Nicole Gri; Chiara Mazzarelli; Iacopo Mangoni; Cristiano Sgrazzutti; Silvia Ghezzi; Andrea Sartore-Bianchi; Luca Saverio Belli; Luciano De Carlis; Angelo Vanzulli; Salvatore Siena; Katia Bencardino
(2025) Cancer treatment reviews 2025 Apr 10.1016/j.ctrv.2025.102908 [40058162] - The complex interplay between aging and cancer.
Lucrezia A Trastus; Fabrizio d'Adda di Fagagna
(2025) Nature aging 2025 Mar 10.1038/s43587-025-00827-z [40038418] - Survival Following CDK4/6 Inhibitor Therapy for Hormone Receptor-Positive, ERBB2-Negative Metastatic Breast Cancer.
Pier Paolo Maria Berton Giachetti; Stefania Morganti; Sara Gandini; Fabiola Giudici; Antonio Marra; Eleonora Nicolò; Emma Zattarin; Chiara Corti; Laura Boldrini; Annarita Verrazzo; Caterina Sposetti; Maria Grazia Razeti; Ambra Carnevale Schianca; Roberta Scafetta; Beatrice Taurelli Salimbeni; Angela Esposito; Paola Zagami; Dario Trapani; Bianca Malagutti; Roberta Caputo; Claudio Vernieri; Elisabetta Munzone; Simone Scagnoli; Andrea Botticelli; Matteo Lambertini; Mario Giuliano; Michelino De Laurentiis; Giulia Viale; Giampaolo Bianchini; Giuseppe Curigliano; Carmine De Angelis; Carmen Criscitiello
(2025) JAMA network open 2025 Feb 03 10.1001/jamanetworkopen.2024.61067 [39982725] - Highlighting recent achievements to advance more effective cancer immunotherapy.
Beatrice Belmonte; Sheila Spada; Paola Allavena; Matteo Benelli; Vincenzo Bronte; Giulia Casorati; Lorenzo D'Ambrosio; Roberto Ferrara; Anna Mondino; Paola Nisticò; Roberta Sommaggio; Marcella Tazzari; Claudio Tripodo; Antonio Sica; Pier Francesco Ferrucci
(2025) Journal of experimental & clinical cancer research : CR 2025 Feb 18 10.1186/s13046-025-03316-8 [39966867] - Evolutionary adaptation to hyperstable microtubules selectively targets tubulins and is empowered by the spindle assembly checkpoint.
Francesca Macaluso; Tasia Bos; Elena Chiroli; Paolo Bonaiuti; Jason C Apuan; Fridolin Gross; Simone Pompei; Luke M Rice; Andrea Ciliberto
(2025) Cell reports 2025 Feb 25 10.1016/j.celrep.2025.115323 [39955777] - Transcriptional enhancers in human neuronal differentiation provide clues to neuronal disorders.
Masahito Yoshihara; Andrea Coschiera; Jörg A Bachmann; Mariangela Pucci; Haonan Li; Shruti Bhagat; Yasuhiro Murakawa; Jere Weltner; Eeva-Mari Jouhilahti; Peter Swoboda; Pelin Sahlén; Juha Kere
(2025) EMBO reports 2025 Mar 10.1038/s44319-025-00372-1 [39948187] - Tumor "age" in early-onset colorectal cancer.
Gianluca Mauri; Giorgio Patelli; Giovanni Crisafulli; Salvatore Siena; Alberto Bardelli
(2025) Cell 2025 Feb 06 10.1016/j.cell.2024.12.003 [39919707] - Acidosis overrides molecular heterogeneity to shape therapeutically targetable metabolic phenotypes in colon cancers.
Elena Richiardone; Maria Virginia Giolito; Rim Al Roumi; Jérôme Ambroise; Romain Boidot; Bernhard Drotleff; Bart Ghesquière; Barbara Lupo; Livio Trusolino; Alberto Bardelli; Sabrina Arena; Olivier Feron; Cyril Corbet
(2025) Cancer letters 2025 Mar 31 10.1016/j.canlet.2025.217512 [39900217] - Defining hypoxia in cancer: A landmark evaluation of hypoxia gene expression signatures.
Matteo Di Giovannantonio; Fiona Hartley; Badran Elshenawy; Alessandro Barberis; Dan Hudson; Hana S Shafique; Vincent E S Allott; David A Harris; Simon R Lord; Syed Haider; Adrian L Harris; Francesca M Buffa; Benjamin H L Harris
(2025) Cell genomics 2025 Feb 12 10.1016/j.xgen.2025.100764 [39892389] - At the nucleus of cancer: how the nuclear envelope controls tumor progression.
Francesca Paganelli; Alessandro Poli; Serena Truocchio; Alberto M Martelli; Carla Palumbo; Giovanna Lattanzi; Francesca Chiarini
(2025) MedComm? 2025 Feb 10.1002/mco2.70073 [39866838] - Regeneration of Vascular Endothelium in Different Large Vessels.
Irina S Sesorova; Eugeny V Bedyaev; Pavel S Vavilov; Sergei L Levin; Alexander A Mironov
(2025) International journal of molecular sciences 2025 Jan 20 10.3390/ijms26020837 [39859550] - Liquid Biopsy and Challenge of Assay Heterogeneity for Minimal Residual Disease Assessment in Colon Cancer Treatment.
Giovanni Crisafulli
(2025) Genes 2025 Jan 09 10.3390/genes16010071 [39858618] - Dynamic mechanisms for membrane skeleton transitions.
Mayte Bonilla-Quintana; Andrea Ghisleni; Nils C Gauthier; Padmini Rangamani
(2025) Journal of cell science 2025 Feb 15 10.1242/jcs.263473 [39838899] - CD36 enrichment in HER2-positive mesenchymal stem cells drives therapy refractoriness in breast cancer.
Lorenzo Castagnoli; Alma Franceschini; Valeria Cancila; Matteo Dugo; Martina Bigliardi; Claudia Chiodoni; Paolo Toneguzzo; Viola Regondi; Paola A Corsetto; Filippo Pietrantonio; Serena Mazzucchelli; Fabio Corsi; Antonino Belfiore; Andrea Vingiani; Giancarlo Pruneri; Francesca Ligorio; Mario P Colombo; Elda Tagliabue; Claudio Tripodo; Claudio Vernieri; Tiziana Triulzi; Serenella M Pupa
(2025) Journal of experimental & clinical cancer research : CR 2025 Jan 20 10.1186/s13046-025-03276-z [39833955] - Concurrent RB1 and P53 pathway disruption predisposes to the development of a primitive neuronal component in high-grade gliomas depending on MYC-driven EBF3 transcription.
Francesca Pagani; Francesca Orzan; Sara Lago; Francesca De Bacco; Marta Prelli; Manuela Cominelli; Elena Somenza; Magdalena Gryzik; Piera Balzarini; Davide Ceresa; Daniela Marubbi; Claudio Isella; Giovanni Crisafulli; Maura Poli; Paolo Malatesta; Rossella Galli; Roberto Ronca; Alessio Zippo; Carla Boccaccio; Pietro Luigi Poliani
(2025) Acta neuropathologica 2025 Jan 16 10.1007/s00401-025-02845-y [39821672] - The integrated stress response drives MET oncogene overexpression in cancers.
Marina Cerqua; Marco Foiani; Carla Boccaccio; Paolo M Comoglio; Dogus M Altintas
(2025) The EMBO journal 2025 Feb 10.1038/s44318-024-00338-4 [39774381] - SP140 represses specific loci by recruiting polycomb repressive complex 2 and NuRD? complex.
Simone Tamburri; Chiara Zucchelli; Vittoria Matafora; Ettore Zapparoli; Zivojin Jevtic; Francesco Farris; Fabio Iannelli; Giovanna Musco; Angela Bachi
(2025) Nucleic acids research 2025 Feb 08 10.1093/nar/gkae1215 [39718989] - Combination of Bremachlorin PDT and Immune Checkpoint Inhibitor Anti-PD-1 Shows Response in Murine Immunological T-cell-High and T-cell-Low PDAC Models.
Roisin McMorrow?; Henriette S de Bruijn; Stefania Farina; Ruben J L van Ardenne; Ivo Que; Pier G Mastroberardino; Dominic J Robinson; Laura Mezzanotte; Clemens W G M Löwik
(2025) Molecular cancer therapeutics 2025 Apr 02 10.1158/1535-7163.MCT-23-0733 [39704624] - Early downmodulation of tumor glycolysis predicts response to fasting-mimicking diet in triple-negative breast cancer patients.
Francesca Ligorio; Andrea Vingiani; Tommaso Torelli; Caterina Sposetti; Lorenzo Drufuca; Fabio Iannelli; Lucrezia Zanenga; Catherine Depretto; Secondo Folli; Gianfranco Scaperrotta; Giuseppe Capri; Giulia V Bianchi; Cristina Ferraris; Gabriele Martelli; Ilaria Maugeri; Leonardo Provenzano; Federico Nichetti; Luca Agnelli; Riccardo Lobefaro; Giovanni Fucà; Giuseppe Fotia; Luigi Mariani; Daniele Morelli; Vito Ladisa; Maria Carmen De Santis; Laura Lozza; Giovanna Trecate; Antonino Belfiore; Silvia Brich; Alessia Bertolotti; Daniele Lorenzini; Angela Ficchì; Antonia Martinetti; Elisa Sottotetti; Alessio Arata; Paola Corsetto; Luca Sorrentino; Mattia Rediti; Giulia Salvadori; Saverio Minucci; Marco Foiani; Giovanni Apolone; Massimiliano Pagani; Giancarlo Pruneri; Filippo de Braud; Claudio Vernieri
(2025) Cell metabolism 2025 Feb 04 10.1016/j.cmet.2024.11.004 [39694040] - dl-Limonene as an Alternative Sustainable Solvent to Xylenes for the Industrial Preparation of Release Formulations.
Giuseppe D'Orazio; Rosa Ragone; Antonino Rizzuti; Francesca Serena Abatematteo; Alessandra Ciampa; Giuseppe Ghisa; Michela Casini; Mario Latronico; Vito Gallo; Piero Mastrorilli; Biagia Musio
(2025) ChemistryOpen? 2025 May 10.1002/open.202400259 [39659060] - HRK downregulation and augmented BCL-xL binding to BAK confer apoptotic protection to therapy-induced senescent melanoma cells.
Clara Alcon; Marta Kovatcheva; Paula Morales-Sánchez; Vanessa López-Polo; Teresa Torres; Susana Puig; Albert Lu; Josep Samitier; Carlos Enrich; Manuel Serrano; Joan Montero
(2025) Cell death and differentiation 2025 Apr 10.1038/s41418-024-01417-z [39627361] - H4K20me3-Mediated Repression of Inflammatory Genes Is a Characteristic and Targetable Vulnerability of Persister Cancer Cells.
Valentina Ramponi; Laia Richart; Marta Kovatcheva; Camille Stephan-Otto Attolini; Jordi Capellades; Alice E Lord; Oscar Yanes; Gabriella Ficz; Manuel Serrano
(2025) Cancer research 2025 Jan 02 10.1158/0008-5472.CAN-24-0529 [39476057] - When molecular biology transforms clinical oncology: the EGFR journey in colorectal cancer.
Pietro Paolo Vitiello; Nadia Saoudi González; Alberto Bardelli
(2025) Molecular oncology 2025 Feb 10.1002/1878-0261.13754 [39470386] - Thioredoxin-interacting protein (TXNIP) is a substrate of the NEDD4-like E3 ubiquitin-protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells.
Sara Giovannini; Yanan Li; Rosalba Pecorari; Claudia Fierro; Claudia Fiorilli; Federica Corigliano; Valeria Moriconi; Ji Zhou; Anna De Antoni; Artem Smirnov; Sara Rinalducci; Anna Maria Timperio; Massimiliano Agostini; Jinping Zhang; Yufang Shi; Eleonora Candi; Gerry Melino; Francesca Bernassola
(2025) Molecular oncology 2025 Jan 10.1002/1878-0261.13722 [39364720] - Traffic light at DSB-transit regulation between gene transcription and DNA repair.
Stefania Modafferi; Francesca Esposito; Sara Tavella; Ubaldo Gioia; Sofia Francia
(2025) FEBS letters 2025 Jan 10.1002/1873-3468.15024 [39333024] - Clinicopathological characterisation of MTAP alterations in gastrointestinal cancers.
Gianluca Mauri; Giorgio Patelli; Laura Roazzi; Emanuele Valtorta; Alessio Amatu; Giovanna Marrapese; Erica Bonazzina; Federica Tosi; Katia Bencardino; Gabriele Ciarlo; Elisa Mariella; Silvia Marsoni; Alberto Bardelli; Emanuela Bonoldi; Andrea Sartore-Bianchi; Salvatore Siena
(2025) Journal of clinical pathology 2025 Feb 18 10.1136/jcp-2023-209341 [38350716]
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