Postdoctoral position to conduct genetic and statistical analyses in the Breast Cancer Genetic Predisposition group lead by Paolo Peterlongo
IFOM is an internationally recognized non-profit cancer research institute supported by the Italian Association for Cancer Research (AIRC) based in Milan within a highly dynamic urban environment.
IFOM continuous success is ensured by the recruitment of highly selected undergraduate, graduate and post-graduate researchers from over 24 countries worldwide.
IFOM is hosted within a research campus shared with the European Institute of Oncology and the Italian Institute of Technology.
IFOM is committed to creating a safe and inclusive environment, based on mutual respect and the enhancement of diversity, offering equal job opportunities to all qualified candidates.
About the position
Open position for a post-doc to work in the Cancer Genetic Predisposition group lead by Paolo Peterlongo within the Genome Diagnostics Program at IFOM in Milan. We have a long-standing research activity in studying the genetic predisposition to breast and ovarian cancer. Several projects have been conducted locally in collaboration with colleagues from INT and IEO in Milan and many other Centers in Italy, and internationally especially with members of large consortia such BCAC – Breast Cancer Association Consortium; CIMBA – Consortium of Investigators of BRCA1/2 Modifiers; ENIGMA – Evidence-based Network for the Interpretation of Germline Mutant Alleles; CONFLUENCE. In particular, covered by funds from an AIRC IG (2019-2024) we are now studying the risk effect of the different sequence variants in the novel breast cancer predisposition gene FANCM. To this aim, we are conducting i) functional experiments and ii) performing genetic analyses and meta-analyses in large international databases and pedigrees. Most recent results are shown in Figlioli et al. Eur J Hum Genet. 2023; Cancers 2023 and 2020; NPJ Breast Cancer 2019; Peterlongo et al. NPJ Breast Cancer 2021 and 2019 Hum Mol Genet 2015; Catucci et al. Genet Med. 2018.
Applicants need to have a PhD degree (or equivalent) in cancer genetics, statistics or genetic epidemiology.
The ideal candidate has:
- hands-on experience on management and curation of large genetic/clinical databases.
- He/she should be able to perform:
- genetic association studies by applying logistic regression or linear regression models
- analysis of survival data by Cox regression and Kaplan-Meier curves
- meta-analyses of case/control studies
- Ability to use statistical tools and programming languages such as STATA or R
- annotation and clinical interpretation of pathogenicity of genetic variants detected by NGS
- knowledge of online databases such as ClinVar, BRCA Exchange, and gnomAD are required.
Type of Contract
Postdoctoral research fellowship renewable on a yearly basis. The salary is internationally competitive and will be commensurate with the experience level of the candidate.
What we offer
International work environment
Guest house inside the Campus
Agreements with discounts for Gym, Pharmacy, Psychology service and various shops around Ifom area
Bar and canteen inside the campus & lunch benefit
Caf service- tax declaration
To apply, please send your cover letter, complete CV and contact information for at least two academic references to paolo.peterlongo[@]ifom.eu indicating Postdoc Position – your name in the subject.