IFOM

Postdoctoral position in d’Adda di Fagagna’s group to study mouse models of aging and aging-related disorders

2021/01 | Postdoctoral position

The group of Fabrizio d’Adda di Fagagna studies the role of DNA damage response (DDR) activation in biologically-relevant settings such as aging and cancer with a special emphasis on cellular senescence (d’Adda di Fagagna Nature 2003, Di Micco Nature 2006, Fumagalli Nature Cell Biology 2012).

Our previous basic findings (Francia Nature 2012, Michelini Nature Cell Biology 2017, Pessina Nature Cell Biology 2019), and our most recent results in vivo (Rossiello Nature Communications 2017, Aguado Nature Communications 2019), demonstrated the efficacy of novel antisense oligonucleotide (ASO) tools to selectively inhibit DDR activation at dysfunctional telomeres, reducing senescence burden and improving healthspan and lifespan.

ABOUT THE POSITION

We have an immediately available opening for an experienced and motivated researcher at the postdoctoral level to study the impact of telomeric DDR inhibition with ASO in mouse models of aging and aging-related disorders.

 

REQUIRED SKILLS

The successful applicant will hold a PhD and a demonstrated experience in mouse model. We seek skills in:

  • mouse husbandry
  • in vivo treatments (IP, IV and SC injections)
  • tissues and organs dissection
  • tissues analyses (nucleic acids and protein extraction, histological analyses)

 

We seek a candidate with a background in aging and/or telomere dysfunction mouse models. Also candidates with experience with the in vivo use of ASO will be considered favorably. Experience in histopathological evaluations or bioinformatics skills is a plus.

Essential is a proven track record of productivity in international peer-reviewed journals. The candidate will be career-oriented, energetic, and capable to take full advantage of our interactive research environment. An attitude or demonstrated ability to translate basic findings into viable options for patients will be highly appreciated. For this reason, candidates transitioning from industry will be considered.

 

WHAT WE OFFER

An internationally competitive salary will be commensurate with skills and experience.
IFOM is part of a campus that hosts about 500 people and results from the integration of IFOM, IEO (European Institute of Oncology) and a branch of IIT (Italian Institute of Technology). It presently hosts more than 50 independent research groups, a PhD school (SEMM), and excellent core facilities. IFOM has joint laboratories in Singapore and India. Milan is a vibrant city, located close to the Alps, the lakes region and the Mediterranean Sea.

 

CONTACT DETAILS

Candidates should send their CV together with a cover letter describing their interest in applying for the role and explain how they meet the set criteria, and contact details of their referees to fabrizio.dadda[@]ifom.eu. Consideration of applications will begin as they are received and will continue until the position is filled.

last update: 24/02/21
Disclaimer privacy

ITA - (articolo 13 del Regolamento UE 2016/679) La informiamo che i suoi dati saranno trattati da IFOM Fondazione Istituto FIRC di Oncologia Molecolare per le sole finalità di selezione. La base giuridica del trattamento è, ai sensi dell’art. 6, par. 1, lett. b), l’esecuzione di misure precontrattuali su richiesta dell’interessato. I suoi dati potranno essere comunicati a terze parti localizzate anche in Paesi fuori dall’Unione Europea ai soli fini della valutazione e selezione delle candidature per la posizione a cui si sta candidando. In tal caso, IFOM ottiene le necessarie garanzie affinché il trasferimento dei Dati sia effettuato conformemente a quanto prescritto al Capo V del GDPR. curricula ricevuti saranno eliminati al termine dell’anno solare successivo a quello di ricezione; qualora lei fosse ancora interessato a proporci la sua candidatura dovrà necessariamente effettuare un nuovo invio Ai sensi degli artt. 15 e ss. del Regolamento UE 2016/679 per esercitare i suoi diritti può scrivere al Titolare dei dati: IFOM Fondazione Istituto FIRC di Oncologia Molecolare, via Adamello 16, Milano, privacy-desk[@]ifom.eu. Infine, Le indichiamo che IFOM ha nominato un Responsabile della Protezione dei Dati (DPO) contattabile al seguente indirizzo dpo[@]ifom.eu.

ENG - (Article 13 of the EU Regulation 2016/679) We inform you that the archiving and processing of data referring to you are carried out by IFOM Fondazione Istituto FIRC di Oncologia Molecolare in order to perform the recruitment process. Pursuant to Article 6(1)(b) the legal basis for the processing is the necessity to take steps at the request of the data subject prior to entering into a contract. Your data shall be communicated to third parties that could be located in countries outside the European Union for the recruitment process. IFOM has obtained the necessary guarantees to transfer the Data in compliance with the provisions of Chapter V of the GDPR. The resumes received will be deleted at the end of the calendar year following the one of receipt; if you are still interested in proposing your application you will have to re-send. According to Article 15 et seq of the EU Regulation 2016/679 to exercise your rights you can write to the Data Controller: IFOM Fondazione Istituto FIRC di Oncologia Molecolare, via Adamello 16, Milano, privacy-desk[@]ifom.eu. Finally, we inform you that IFOM has appointed a Data Protection Officer (DPO) who can be contacted at dpo[@]ifom.eu.