IFOM Pubblicazioni Francesco Blasi

Pubblicazioni Francesco Blasi

  1. Fazioli, F, Resnati, M, Sidenius, N, Higashimoto, Y, Appella, E and Blasi, F.
    The urokinase-sensitive region of the urokinase receptor is responsible for its potent chemotactic activity.
    EMBO J., 16, 7279-7286. (1997)

  2. Berthelsen, J., Zappavigna, V., Mavilio, F. and Blasi, F.
    Prep1, a novel functional partner of Pbx proteins.
    EMBO J., 17, 1423-1433, (1998)

  3. Berthelsen, J., Zappavigna, V., Ferretti, E., Mavilio, F. and Blasi, F.
    Prep1, a novel partner of Pbx proteins, modifies Pbx-Hox protein cooperativity.
    EMBO J., 17, 1434-1445 (1998)

  4. Berthelsen, J., Kilstrup-Nielsen, C., Blasi, F., Mavilio, F. and Zappavigna, V.
    The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH.
    Gen. Dev. , 13, 946-953 (1999)

  5. E. Ferretti, H. Marshall, H. Pöpperl, M. Maconochie, R. Krumlauf and F. Blasi.
    A complex site including both Pbx-Hox and Prep-Meis-responsive elements and binding a retinoic acid-inducible ternary Hoxb1-Pbx-Prep1 complex is required for HOXB2 rhombomere 4 expression.
    Development, 127, 155-166, (2000)

  6. Thorsteinsdottir, U., Kroon, E., Jerome,L., Blasi, F and Sauvageau, G.
    Defining role for Hox genes and their common collaboration with MEIS1 in the induction of AML.
    Mol. Cell Biol., 21, 224-234 (2001)

  7. Resnati, M. , Pallavicini, I. , Wang, J.M., Oppenheim, J., Serhan, C.N., Romano, M. e Blasi, F.
    The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R.
    Proc. Natl. Acad. Sci. U.S.A. 99, 1359-1364. (2002)

  8. Blasi, F. and Carmeliet, P.
    uPAR: a versatile signaling orchestrator.
    Nature Rev. Mol. Biol. 3, 932-943. (2002)

  9. Cunningham, O., Andolfo, AP, Santovito, AL, Iuzzolino, L., Blasi, F. and Sidenius, N.
    Differential lipid raft partitioning of the urokinase receptor regulates its biological functions and is controlled by receptor dimerization.
    EMBO J. 22, 5994-6003 (2003)

  10. Cinque, P., Nebuloni, M., Santovito, M., Price, R.W. , Gisslen, M., Hagberg,, L., Bestetti, A., Vago, G., Lazzarin, A., Blasi, F. and Sidenius, N.
    The urokinase receptor is overexpressed in AIDS dementia complex and other neurological manifestations.
    Ann. Of Neurol., 55, 687-694 (2004). IF: 7.717

  11. Furlan, F., Orlando, S., Laudanna, C., Resnati, M., Basso, V., Blasi, F. and Mondino, A.
    The soluble D2D3(88-274) fragment of the urokinase receptor inhibits monocyte chemotaxis and integrin-dependent cell adhesion.
    J. Cell Sci., 117, 2909-2916, (2004). IF: 7.250

  12. Mondino, A. and Blasi. F.
    UPA and uPAR in fibrinolysis, immunity and pathology.
    Trends in Immunology. 25, 450-455. IF: 18.153 (2004)

  13. Selleri, C., Montuori, N., Ricci, P., Visconte, V., Carriero, MV, Sidenius, N., Serio, B., Blasi, F., Rotoli, B., Rossi, G., Ragno, P.
    Involvement of the urokinase-type plasminogen activator receptor in hematopoietic stem cell.
    Blood. 2005 105:2198-2205. IF: 10.120

  14. Bernard Degryse, Massimo Resnati, Ralf-Peter Czekay, David J. Loskutoff, and Francesco Blasi.
    Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor.
    J. Biol. Chem., 280, 24792-24803 (2005).

  15. Ferretti, E., Cambronero, F., Tumpel, S., L. Weidemann, Blasi, F. and Krumlauf, R.
    The Hoxb1 enhancer and control of rhombomere 4 expression: Complex interplay between PREP1-PBX1-HOXB1 binding sites.
    Mol Cell Biol, 25, 8541-8552 (2005).

  16. Penkov, D, Di Rosa, P, Fernandez Diaz, L, Basso, V, Ferretti, E, Grassi, F, Mondino, A and Blasi, F.
    Involvement of Prep-1 in the abTCR T-lymphocytic potential of hematopoietic precursors.
    Mol Cell Biol, 25, 10768-10781 (2005).

  17. Mazzieri, R., D'Alessio, S., Kamgang-Kemhoe, R., Ossowski, L. and Blasi, F.
    An uncleavable uPAR mutant allows dissection of signaling pathways in uPA-dependent cell migration.
    Mol Biol Cell. 17, 367-78, (2006).

  18. Ferretti, E., J.Carlos Villaescusa, Patrizia Di Rosa, Luis C. Fernandez-Diaz, Elena Longobardi, Roberta Mazzieri, Annarita Miccio, Nicola Micali, Licia Selleri, Giuliana Ferrari and Francesco Blasi.
    Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype.
    Mol. Cell. Biol. 26:5650-5662. (2006).

  19. Mazzieri, R, Furlan, F, D'Alessio, S. , Zonari, E., S, M, Talotta, F., Verde, P and Blasi, F.
    A direct link between expression of urokinase plasminogen activator receptor (uPAR), growth rate and oncogenic transformation in mouse embryonic fibroblasts.
    Oncogene, 26:725-32. (2007)

  20. Ferrai, C., Munari, D., Luraghi, P., Pecciarini,, L., Cangi,, M.G., Doglioni, C., Blasi, F. and Crippa, M.P.
    A transcription-dependent MNase-resistant fragment of the uPA promoter interacts with the enhancer.
    J. Biol. Chem. 282:12537-12546. (2007)

  21. Díaz, V. M., Bachi, A. and Blasi, F.
    Purification of the Prep1 interactome identifies novel pathways regulated by Prep1.
    Proteomics. 2007. 7:2617-2623. (2007)

  22. Federico Furlan, Clara Galbiati, Niklas R. Jorgensen, Jens-Erik B. Jensen, Emanuela Mrak, Alessandro Rubinacci, Francesco Talotta Pasquale Verde and Francesco Blasi.
    Role of urokinase plasminogen activator receptor in bone homeostasis. 
    J. Bone Min. Res. 22: 1387-96. (2007)

  23. Di Rosa, P., Villaescusa, J.C., Longobardi, E., Iotti, G., Ferretti, E., Diaz, V.M., Miccio, A., Ferrari G. and Francesco Blasi.
    Homeodomain transcription factor Prep1 (pKnox1) is required for hematopoietic stem cells and progenitors activity.
    Devel. Biol. 311, 324-334. (2007)

  24. Diaz, VM Mori, S, Longobardi, E, Menendez, G., Ferrai, C. RA Keough, A Bachi and F Blasi.
    p160 myb-binding-protein interacts with Prep1 and inhibits its transcriptional activity.
    Mol. Cell Biol. 27, 7981-7990. (2007)

  25. Degryse, B., Fernandez-Recio, J. , Citro, V., Blasi, F., Cubellis M.V.
    In silico docking of urokinase plasminogen activator and integrins.
    BMC Bioinformatics. 2008 Mar 26;9 Suppl 2:S8.

  26. Caiolfa V, Zamai M, Malengo G, Andolfo A, Madsen CD, Sutin J, Digman M, Gratton E, Blasi F, Sidenius N.
    Monomer-dimer dynamics and distribution of GPI-anchored uPAR are determined by cell surface protein assemblies.
    J. Cell Biol., 179, 1067-1082. (2007)

  27. Penkov D, Palazzolo M, Mondino A, Blasi F. Cytosolic sequestration of Prep1 influences early stages of T cell development.
    PLoS ONE. 2008, Jun 18;3(6); e2424. NO IF

  28. Cortese K, Sahores M, Madsen CD, Tacchetti C, Blasi F.
    Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR.
    PLoS ONE. 2008, 3(11); e3730. NO IF

  29. D'Alessio, S., Gerasi, L. and Blasi, F.
    The urokinase receptor (uPAR) Ko mice keratinocytes fail to produce EGF-receptor-dependent Laminin-5 affecting migrationin vitro and in vivo.
    2008. J Cell Sci 121, 3922-3932.

  30. F. Oriente, L.C. Fernandez Diaz, C. Miele, S. Iovino, S. Mori, V. E. Diaz, G. Troncone, A. Cassese, P. Formisano, F. Blasi, F. Beguinot.
    Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160a-mediated mechanism.
    2008. Mol Cell Biol 28, 5634-5645.

  31. Matafora, V, D'Amato, A, Mori, S, Blasi, F, Bachi, A.
    Proteomic analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.
    In press, Mol.Cell. Proteomics (2009), 8.10, 2243-2255.

  32. Blasi, F, Sidenius, N.
    Efferocytosis: another function of uPAR.
    Blood. 14(4):752-7533 (2009)

  33. Ferrai, C., Naum-Ongania, G., Palazzolo, M., Longobardi, E., Disanza, A., Diaz, V.M., Crippa, M.P., Scita, G. and Blasi, F.
    Induction of HoxB transcription by retinoic acid requires actin polymerization.
    Mol Biol Cell, 20, 3525-3533m, 2009.

  34. Villaescusa, JC, Buratti, C, Penkov, D, Mathiasen, L, Planagumà, J, Ferretti, E and Blasi, F.
    Cytoplasmic Prep1 interacts with 4EHP inhibiting HoxB4 translation.
    PLOS One (2009). 4:e5213. Epub 2009 Apr 13

  35. Tjwa, M, Sidenius, N, Moura, R, Jansen, S, Theunissen, K, Moons, L, Andolfo, A, De Mol, M, Dewerchin, M, Blasi, F, Verfaillie, C, Carmeliet, P.
    Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment and mobilization of hematopoietic stem/progenitor cells.
    J. Clin. Invest. 2009. 119, 1008-1018.

  36. Micali, N. Ferrai, C., Fernandez Diaz, L.C., Blasi, F and Crippa, M.P.
    Prep1 regulates the intrinsic apoptotic pathway by directly controlling Bcl-XL expression.
    MCB. 29, 1143-1151. (2009)

  37. Longobardi, E., Iotti, G., Di Rosa, P., Meietta, S., Nuciforo, P., Ponzoni, M., Doglioni, C., Caniatti, P., Bianchi, F., Di Fiore, P.P. and Blasi, F.
    The homeodomain transcription factor Prep1 gene (pKnox1)is a haploinsufficient tumor suppressor in man and mice.
    Molecular Oncology, 2010. 4, 226-234.

  38. Micali, N., Longobardi, E., Iotti, G., Ferrai, C., Castagnaro, L., Ricciardi, M., Blasi, F. and Crippa, M.
    Down Syndrome and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress.
    Nucleic Acids Research, 38:3595-604, 2010.

  39. Fernandez-Diaz, L. C., Laurent, A., Girasoli, S., Turco, M., Longobardi, E., Iotti, G., Jenkins, N. A., Fiorenza, M.T., Copeland, N. G. and Blasi, F.
    The absence of Prep1 causes p53-dependent apoptosis of pluripotent epiblast cells.
    Development, 137:3393-3403, 2010.

  40. Oriente, F, Iovino, S, Cabaro, S, Cassese, A, Longobardi, E, Miele, E, Ungaro, P, Formisano, P, Blasi, F and Beguinot, F.
    Prep1 controls insulin glucoregulatory function in liver by transcriptional targetting of SHP1 tyrosine phosphatase.
    Diabetes, 2011, 60, 138-147.

  41. Bernardi, E, De Florian, G, Diaz, VM, Mione, M, Blasi, F.
    Characterization of the regulatory region of the zebrafish Prep1.1 gene: analogies to the promoter of the human PREP1.
    PLOS One, 2010 Dec 22;5(12):e15047.

  42. Iotti G., Longobardi E., Masella S., Dardaei L., De Santis F., Micali N., and Blasi F.
    The Homeodomain Transcription Factor Prep1 is required to maintain Genomic Stability.
    Proc Natl Acad Sci U S A. 18, E 314-E332 (2011). Doi 10.173/pnas. 1105216108.

  43. Mori, S, Bernardi, R, Laurent, A, Resnati, M, Crippa, A, Gabrieli, A, Keough, R, Gonda, TJ and Blasi, F.
    Myb-binding protein 1a (MYBBP1A) is developmentally essential, acts as a tumor suppressor and is required in the G2/M phase of the cell cycle.

    PLOS ONE. 2012.

  44. Iotti, G, Mejetta, S., Modica, L, Penkov, D., Ponzoni, M. and Blasi, F.
    Reduction of Prep1 levels affects differentiation of normal and malignant B cells and accelerates Myc driven lymphomagenesis.
    PLoS ONE 7(10): e48353. doi:10.1371/journal.pone.0048353 (2012)

  45. D. Penkov, D. Mateos San Martin, L. C. Fernandez-Diaz, C. A. Rosselló, C. Torroja, F. Sánchez-Cabo, H.J. Warnatz, M.L. Yaspo, A. Gabrieli, V. Tkachuk, L. Selleri, A. Brendolan, F. Blasi and M. Torres.
    Analysis of the in vivo DNA-binding profile and function of TALE homeoproteins reveals their specialization and differential interactions with Hox genes and proteins.
    Cell Reports, in press, 2013.

  46. Naum-Onganía, G, Díaz, VM, Blasi, F and Rivera-Pomar, R. 2013.
    Nuclear actin polymerization from faster growing ends in the initial activation of hox gene transcription. Are nuclear speckles involved?
    Transcription, 4: 260–272.

  47. Kanzleiter, T, Rath, M, Penkov, D, Puchkov, D, Schulz, N, Blasi, F and Schürmann, A.
    Pknox1/Prep1 regulates mitochondrial oxidative phosphorylation components in skeletal muscle.
    Mol Cell Biol, 2013, 34:290-298

  48. Longobardi E, Penkov D, Mateos D, De Florian G, Torres M and Blasi F.
    Biochemistry of the TALE transcription factors Prep, Meis and Pbx in vertebrates.
    Devel. Dynamics, 2014, 243, 59-75.

  49. Oriente, F, Cabaro, S, Antonietta Liotti, Michele Longo, Luca Parrillo, Teresa B. Pagano, Dmitry Penkov, Orlando Paciello, Claudia Miele, Pietro Formisano, Francesco Blasi and Francesco Beguinot.
    Prep1 deficiency downregulates hepatic lipogenesis and attenuates steatohepatitis in mice.
    Diabetologia, 2013, 56:2713-22.

  50. Dardaei, L, Longobardi, E and Blasi, F.
    Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis.
    PNAS Plus. 2014. 111:E896-905.

  51. Dardaei L, Modica L, Iotti G, Blasi F (2014)
    The Deficiency of Tumor Suppressor Prep1 Accelerates the Onset of Meis1- Hoxa9 Leukemogenesis.
    PloS ONE 9(5): e96711. doi:10.1371/journal.pone.0096711

  52. Modica, L, Iotti, G, D'Avola A, Blasi, F. 2014 .
    Prep1 (pKnox1) regulates embryonic mouyse HSC cycling and self-renewal via the Stat1-Sca1 IFN-dependent pathway.
    PLOS One, 9:e107916. doi: 10.1371/journal.pone.0107916. eCollection 2014.

  53. Risolino, M, Mandia, N, Iavarone, F, Dardaei, L,Longobardi, E, Fernandez, S, Talotta, F, Bianchi, F, Pisati, F, Spaggiari, L, Harter, PN, Mittelbronn, M, Schulte, D, Incoronato, MR, Di Fiore, PP, Blasi, F & Verde, P. 2014 .
    The transcription factor PREP1 induces EMT and metastasis by controlling the TGF-beta-SMAD3 pathway in non-small cell lung adenocarcinoma.
    PNAS Plus. 111:E3775-84. doi: 10.1073/pnas.1407074111. PMID: 25157139

  54. Talukder AK, Ravishankar S, Sasmal K, Gandham S, Prabhukumar J, Achutharao PH, et al. (2015)
    XomAnnotate: Analysis of Heterogeneous and Complex Exome- A Step towards Translational Medicine.
    PLoS ONE 10: e0123569. doi:10.1371/journal.pone.0123569

  55. Laurent A, Calabrese M, Warnatz HJ, Yaspo ML, Tkachuk V, Torres M, Blasi F, Penkov D. 2015.
    ChIP-Seq and RNA-Seq analyses identify components of the Wnt and Fgf signaling pathways as Prep1 target genes in mouse embryonic stem cells.
    PLoS One. Apr 13;10(4):e0122518. doi: 10.1371/journal.pone.0122518. eCollection 2015

  56. Mathiasen, L, Bruckmann, C, Pasqualato, S and Blasi, F.
    Purification and characterization of a DNA-binding recombinant PREP1:PBX1 complex.
    PLOS One, 2015, 10.1371/journal.pone.0125789

  57. Laurent, A & Blasi, F.
    Differential DNA damage signalling and apoptotic threshold trigger mouse epiblast-specific radiation hypersensitivity.
    Development, 2015. 142:3675-3685

  58. Dardaei, L, Penkov, D, Mathiasen, L, Bora, P, Morelli, M J and Blasi, F.
    Meis1 overexpression causes a change of DNA target-sequence specificity which allows binding to the AP-1 element.
    Oncotarget, 2015. 6:25175-87

  59. Mazzieri, R., Gerasi, L., Pietrogrande, G., Merulla, J., SA., Brombin, C., Ambrosi, Janich, P., Benitah, A., Blasi, F. and D'Alessio, S.
    Urokinase receptor (uPAR) promotes skin tumor formation by preventing epithelial cell activation of Notch1.
    2015. Cancer Research, 75:4895-909

  60. Elisa Lenti, Diego Farinello, Kazunari Yokoyama, Penkov Dmitry, Laura Castagnaro, Giovanni Lavorgna, Kenly Wuputra, Lisa Sandell, Naomi Butler Tjaden, Francesca Bernassola, Michael Wagner, Karen Niederreither, Francesco Blasi, Diego Pasini, Giovanni Tonon, Paul Trainor, and Andrea Brendolan. 2015.
    The Oncogenic Transcription Factor TLX1 Regulates Cyp26b1 Expression and Retinoic Acid Signaling to Ensure Spleen Development.
    Submitted, J. Exp. Med.

  61. Lisa Mathiasen, Erica Valentini, Stephane Boivin, Angela Cattaneo, Francesco Blasi, Dmitry I. Svergun, Chiara Bruckmann
    The flexibility of a homeodomain transcription factor heterodimer and its allosteric regulation by DNA binding.
    Submitted JBC 1