IFOM Thomas Vaccari Lab

Thomas Vaccari Lab

Thomas Vaccari

A native of Milan, Thomas Vaccari is head of the Membrane trafficking and tissue architecture Laboratory at IFOM.
In 1997 he graduated with honors in biology at the University of Milan. He later conducted research at San Raffaele Hospital and the Mario Negri Institute in Milan, and, in 2003, completed his doctoral studies in cell and developmental biology, again with honors, at EMBL Heidelberg, Germany. read more

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Membrane Trafficking and Tissue Architecture

Our lab studies how endocytosis modulates signaling to the effect of controlling tissue growth and architecture in Drosophila epithelial organs. This interest springs from the fact that control of tissue growth and architecture is tumor suppressive and its alteration contributes to pathological states including malignant transformation. read more

Laboratory location: Milan, Italy

Recent publications

  • Morelli E, Mastrodonato V, Beznoussenko G, Mironov AA, Tognon E, Vaccari T (2016).
    An essential step of kinetochore formation controlled by the SNARE protein Snap29.
    EMBO Journal pii: e201693991.
  • Tognon E, Kobia F, Busi I, Fumagalli A, De Masi F, Vaccari T (2016).
    Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB/V-ATPase axis in Drosophila melanogaster.
    Autophagy 12(3):499-514.
  • Morelli E, Ginefra P, Mastrodonato V, Beznoussenko G, Rusten TE, Bilder D, Stenmark H, Mironov AA, Vaccari T (2014).
    Multiple functions of the SNARE protein Snap29 in autophagy, endocytic and exocytic trafficking during epithelial formation in Drosophila.
    Autophagy. 10(12):2251-68.

Group members

Postdoc
Elena Morelli (FIRC fellow)
Piera Calamita (Visiting INGM)
PhD students
Valeria Mastrodonato (FUV fellow)
Victor Alfred
Miriam Formica (Visiting UNIMI)
Undergraduate Students
Francesca Carminati (UNIMI)
Marco Gualtieri (UNIMI)
Elisa Speranza (UNIMI)
Former Group members
Francis Kobia (Postdoc, Kopan lab, Cincinnati Children's Hospital Medical Center, USA)
Emiliana Tognon (Postdoc, Longo lab, IFOM/UCLA, Italy/USA)
Ilaria Busi (R&D, Sakura farmaceutici, Italy)
Usha Nagarajan (Research Fellow, Queens Medical Center, University Of Nottingham, UK)
Rohan Kadilkar (Postdoc, Tanentzapf lab, University of British Columbia, Canada)
Arianna Fumagalli (PhD student, van Rheenen's lab; Hubrecht Institute, The Netherlands)
Anke Witt (PhD student, Zerial lab, MPI-CBG Dresden, Germany)
Nadine Wossner (Clinical Monitor, IZKS, Mainz, Germany)
Pierpaolo Ginefra (PhD student, Constam's lab at EPFL, Switzerland)
Ambra Bianco (R&D Astra-Zeneca, Cambridge, UK)
Serena Duchi (Staff Scientist, Rizzoli Orthopaedic Institute, Bologna, Italy)

IFOM Review

Vacuolar ATPase control of signaling and tumorigenesis
Commentary on Thomas Vaccari's paper published on Molecular oncology, by Angelika M. Vollmar (2013)
complete review

In the press

La genetica diventa 'multiplex', modifica più geni in una volta
Ansa

2015.06.08 | Monica Nardone

La genetica diventa "multiplex"
Il Corriere Adriatico

2015.06.06

Lezioni a scuola e cioccolato in piazza - così l'Airc celebra i giorni della ricerca
La Repubblica - ed. Milano
2012.11.09 | Carlo Brambilla
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