IFOM Andrea Ciliberto Lab

Andrea Ciliberto Lab

Andrea Cliberto

Andrea Ciliberto

Andrea Ciliberto, a biologist expert in the mathematical modeling of biological processes, directs the Quantitative Biology of Cell Division research program at IFOM.
Born in Florence in 1971, Ciliberto graduated from the University of Florence in 1995 with a degree in Biological Sciences, defending a thesis on the dynamics of replication in cell populations. From the beginning of his academic career, Ciliberto has also had a strong interest in the applications of mathematics to the life sciences. read more

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Quantitative Biology of Cell Division

Our lab is interested in studying molecular regulatory networks using both computational and experimental approaches.
Metaphase-to-anaphase transition
Our main interest lies in the analysis of the general principles of cell cycle control, with particular emphasis on the exit from mitosis. Normally, cells make sure that the two daughter cells born at the end of a cell cycle inherit one sister chromatid each, and thus are genetically equivalent to their mother cell. read more

Laboratory location: Milan, Italy

Recent publications

  • Capuani F, Conte A, Argenzio E, Marchetti L, Priami C, Polo S, Di Fiore PP, Sigismund S, Ciliberto A.
    Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells.
    Nat Commun. 2015 Aug 12;6:7999. doi: 10.1038/ncomms8999. PubMed PMID: 26264748; PubMed Central PMCID: PMC4538861.
  • Vernieri C, Chiroli E, Francia V, Gross F, Ciliberto A.
    Adaptation to the spindle checkpoint is regulated by the interplay between Cdc28/Clbs and PP2ACdc55.
    J Cell Biol. 2013 Sep 2;202(5):765-78. doi: 10.1083/jcb.201303033. PubMed PMID: 23999167; PubMed Central PMCID: PMC3760609.
  • Mariani L, Chiroli E, Nezi L, Muller H, Piatti S, Musacchio A, Ciliberto A.
    Role of the Mad2 dimerization interface in the spindle assembly checkpoint independent of kinetochores.
    Curr Biol. 2012 Oct 23;22(20):1900-8. doi: 10.1016/j.cub.2012.08.028. Epub 2012 Sep 20. PubMed PMID: 23000150.

Group members

Post Docs
Elena Chiroli
Tiziana Lischetti
PhD students
Paolo Bonaiuti
Andrea Corno
Master Students
Federica Natali
Mattia Pavani

IFOM Review

Insights into the Mechanics of Adaptation to Spindle Assembly Checkpoint
Commentary on Andrea Ciliberto's paper published on eLife, by Uttam Surana (2013)
A new light on Spindle assembly checkpoint in chromosome distribution
Commentary on Andrea Ciliberto's paper published on Current Biologys, by Silke Hauf (2012)
complete review

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