Andrea Ciliberto Lab
Andrea Ciliberto
Andrea Ciliberto, a biologist expert in the mathematical modeling of biological processes, directs the Quantitative Biology of Cell Division research program at IFOM.
Born in Florence in 1971, Ciliberto graduated from the University of Florence in 1995 with a degree in Biological Sciences, defending a thesis on the dynamics of replication in cell populations. From the beginning of his academic career, Ciliberto has also had a strong interest in the applications of mathematics to the life sciences. read more
Quantitative Biology of Cell Division
Our lab is interested in studying molecular regulatory networks using both computational and experimental approaches.
Metaphase-to-anaphase transition
Our main interest lies in the analysis of the general principles of cell cycle control, with particular emphasis on the exit from mitosis. Normally, cells make sure that the two daughter cells born at the end of a cell cycle inherit one sister chromatid each, and thus are genetically equivalent to their mother cell. read more
Recent publications
- Bonaiuti P, Chiroli E, Gross F, Corno A, Vernieri C, Štefl M, Cosentino Lagomarsino M, Knop M, Ciliberto A.
Cells Escape an Operational Mitotic Checkpoint through a Stochastic Process.
Curr Biol. 2018 Jan 8;28(1):28-37.e7. doi: 10.1016/j.cub.2017.11.031.
Epub 2017 Dec 14. - Capuani F, Conte A, Argenzio E, Marchetti L, Priami C, Polo S, Di Fiore PP,
Sigismund S, Ciliberto A.
Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells.
Nat Commun. 2015 Aug 12;6:7999. doi: 10.1038/ncomms8999. PubMed PMID: 26264748; PubMed Central PMCID: PMC4538861. - Vernieri C, Chiroli E, Francia V, Gross F, Ciliberto A.
Adaptation to the spindle checkpoint is regulated by the interplay between Cdc28/Clbs and PP2ACdc55.
J Cell Biol. 2013 Sep 2;202(5):765-78. doi: 10.1083/jcb.201303033. PubMed PMID: 23999167; PubMed Central PMCID: PMC3760609.
IFOM Review
Insights into the Mechanics of Adaptation to Spindle Assembly Checkpoint
Commentary on Andrea Ciliberto's paper published on eLife, by Uttam Surana (2013)